The SUMO protease SENP1 promotes aggressive behaviors of high HIF2α expressing renal cell carcinoma cells

The SUMO protease SENP1 promotes aggressive behaviors of high HIF2α expressing renal cell carcinoma cells

Abstract While an important role for the SUMO protease SENP1 is recognized in multiple solid cancers, its role in renal cell carcinoma (RCC) pathogenesis, particularly the most dominant subtype, clear cell RCC (ccRCC), is poorly understood. Here we show that a combination of high HIF2α and SENP1 exp...

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Bibliographic Details
Main Authors: Moon Hee Lee, Kyung Sung, David Beebe, Wei Huang, Dan Shapiro, Shigeki Miyamoto, E. Jason Abel
Format: Article
Language:English
Published: Nature Publishing Group 2022-10-01
Series:Oncogenesis
Online Access:https://doi.org/10.1038/s41389-022-00440-4

Internet

https://doi.org/10.1038/s41389-022-00440-4

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