Optimal construction of a functional interaction network from pooled library CRISPR fitness screens
Abstract Background Functional interaction networks, where edges connect genes likely to operate in the same biological process or pathway, can be inferred from CRISPR knockout screens in cancer cell lines. Genes with similar knockout fitness profiles across a sufficiently diverse set of cell line s...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2022-11-01
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| Series: | BMC Bioinformatics |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12859-022-05078-y |