Familial mediterranean fever: clinical case
Background. Familial Mediterranean fever (FMF) is the brightest exponent of autoinflammatory diseases. FMF usually occurs to people of Mediterranean origin (Jews, Armenians, Azerbaijanis, Arabs, Kurds, Greeks, Turks and Italians). This is a hereditary disease with the autosomal recessive inheritance...
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| Format: | Article |
| Language: | English |
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Eco-vector
2019-04-01
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| Series: | Клиническая практика |
| Subjects: | |
| Online Access: | https://journals.eco-vector.com/clinpractice/article/viewFile/10950/9291 |
| _version_ | 1797760142593228800 |
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| author | Roman S. Saykovskiy S. V. Sadovnikova |
| author_facet | Roman S. Saykovskiy S. V. Sadovnikova |
| author_sort | Roman S. Saykovskiy |
| collection | DOAJ |
| description | Background. Familial Mediterranean fever (FMF) is the brightest exponent of autoinflammatory diseases. FMF usually occurs to people of Mediterranean origin (Jews, Armenians, Azerbaijanis, Arabs, Kurds, Greeks, Turks and Italians). This is a hereditary disease with the autosomal recessive inheritance. Includes history of research, epidemiology FMF, variants of the disease course, methods of treatment.
Clinical case description. A 61-year-old woman arrived complaining of weakness, fever, joint pain. First sign of disease showed at 20-years-old. When she came in: WBC 20.1109/l, HGB 6.7 g/ml, ESR 60 mm/h, CRP 100 mg/l, CRP 202 mol/L, UREA 19.7 mmol/L. Quantity of protein in one liter of urine 0.160 g. Ultrasonic signs of pyelectasis in both kidneys. The diagnosis was made on the basis of characteristic attacks of fever, polyarthritis, thoracalgia of Armenian nationality patient. The diagnosis was confirmed by the detection of amyloidosis and genetic data.
Conclusion. Knowledge of the FMF clinical profile is important for differential diagnosis with many acute conditions, e.g. acute abdomen, myocardial infarction, pneumothorax, rheumatic diseases. It is important to remember that untimely diagnosis and improper treatment lead to the development of AA-amyloidosis (3040%) with the outcome of renal failure. |
| first_indexed | 2024-03-12T18:54:29Z |
| format | Article |
| id | doaj.art-5eee1903998f4d37a70b074e0b88778b |
| institution | Directory Open Access Journal |
| issn | 2220-3095 2618-8627 |
| language | English |
| last_indexed | 2024-03-12T18:54:29Z |
| publishDate | 2019-04-01 |
| publisher | Eco-vector |
| record_format | Article |
| series | Клиническая практика |
| spelling | doaj.art-5eee1903998f4d37a70b074e0b88778b2023-08-02T06:58:53ZengEco-vectorКлиническая практика2220-30952618-86272019-04-0110110110710.17816/clinpract101101-10710173Familial mediterranean fever: clinical caseRoman S. Saykovskiy0S. V. Sadovnikova1Federal Scientific and Clinical Center for Specialized Medical Assistance and Medical Technologies of the Federal Medical Biological AgencyFederal Scientific and Clinical Center for Specialized Medical Assistance and Medical Technologies of the Federal Medical Biological AgencyBackground. Familial Mediterranean fever (FMF) is the brightest exponent of autoinflammatory diseases. FMF usually occurs to people of Mediterranean origin (Jews, Armenians, Azerbaijanis, Arabs, Kurds, Greeks, Turks and Italians). This is a hereditary disease with the autosomal recessive inheritance. Includes history of research, epidemiology FMF, variants of the disease course, methods of treatment. Clinical case description. A 61-year-old woman arrived complaining of weakness, fever, joint pain. First sign of disease showed at 20-years-old. When she came in: WBC 20.1109/l, HGB 6.7 g/ml, ESR 60 mm/h, CRP 100 mg/l, CRP 202 mol/L, UREA 19.7 mmol/L. Quantity of protein in one liter of urine 0.160 g. Ultrasonic signs of pyelectasis in both kidneys. The diagnosis was made on the basis of characteristic attacks of fever, polyarthritis, thoracalgia of Armenian nationality patient. The diagnosis was confirmed by the detection of amyloidosis and genetic data. Conclusion. Knowledge of the FMF clinical profile is important for differential diagnosis with many acute conditions, e.g. acute abdomen, myocardial infarction, pneumothorax, rheumatic diseases. It is important to remember that untimely diagnosis and improper treatment lead to the development of AA-amyloidosis (3040%) with the outcome of renal failure.https://journals.eco-vector.com/clinpractice/article/viewFile/10950/9291familial mediterranean feveraseptic inflammationauto-inflammatory diseasesrecurrent aseptic peritonitispolyarthritis |
| spellingShingle | Roman S. Saykovskiy S. V. Sadovnikova Familial mediterranean fever: clinical case Клиническая практика familial mediterranean fever aseptic inflammation auto-inflammatory diseases recurrent aseptic peritonitis polyarthritis |
| title | Familial mediterranean fever: clinical case |
| title_full | Familial mediterranean fever: clinical case |
| title_fullStr | Familial mediterranean fever: clinical case |
| title_full_unstemmed | Familial mediterranean fever: clinical case |
| title_short | Familial mediterranean fever: clinical case |
| title_sort | familial mediterranean fever clinical case |
| topic | familial mediterranean fever aseptic inflammation auto-inflammatory diseases recurrent aseptic peritonitis polyarthritis |
| url | https://journals.eco-vector.com/clinpractice/article/viewFile/10950/9291 |
| work_keys_str_mv | AT romanssaykovskiy familialmediterraneanfeverclinicalcase AT svsadovnikova familialmediterraneanfeverclinicalcase |