Therapeutic Effects of HIF-1α on Bone Formation around Implants in Diabetic Mice Using Cell-Penetrating DNA-Binding Protein

Therapeutic Effects of HIF-1α on Bone Formation around Implants in Diabetic Mice Using Cell-Penetrating DNA-Binding Protein

Patients with uncontrolled diabetes are susceptible to implant failure due to impaired bone metabolism. Hypoxia-inducible factor 1α (HIF-1α), a transcription factor that is up-regulated in response to reduced oxygen during bone repair, is known to mediate angiogenesis and osteogene...

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Bibliographic Details
Main Authors: Sang-Min Oh, Jin-Su Shin, Il-Koo Kim, Jung-Ho Kim, Jae-Seung Moon, Sang-Kyou Lee, Jae-Hoon Lee
Format: Article
Language:English
Published: MDPI AG 2019-02-01
Series:Molecules
Subjects:
diabetes mellitus
hypoxia-inducible factor-1α
angiogenesis
bone formation
osteogenesis
protein transduction domain
Online Access:https://www.mdpi.com/1420-3049/24/4/760

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