Interplay between Cellular Metabolism and Cytokine Responses during Viral Infection
Metabolism and immune responses are two fundamental biological processes that serve to protect hosts from viral infection. As obligate intracellular pathogens, viruses have evolved diverse strategies to activate metabolism, while inactivating immune responses to achieve maximal reproduction or persi...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2018-09-01
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| Series: | Viruses |
| Subjects: | |
| Online Access: | http://www.mdpi.com/1999-4915/10/10/521 |
| _version_ | 1819212248774606848 |
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| author | Shu Zhang Jessica Carriere Xiaoxi Lin Na Xie Pinghui Feng |
| author_facet | Shu Zhang Jessica Carriere Xiaoxi Lin Na Xie Pinghui Feng |
| author_sort | Shu Zhang |
| collection | DOAJ |
| description | Metabolism and immune responses are two fundamental biological processes that serve to protect hosts from viral infection. As obligate intracellular pathogens, viruses have evolved diverse strategies to activate metabolism, while inactivating immune responses to achieve maximal reproduction or persistence within their hosts. The two-way virus-host interaction with metabolism and immune responses choreograph cytokine production via reprogramming metabolism of infected cells/hosts. In return, cytokines can affect the metabolism of virus-infected and bystander cells to impede viral replication processes. This review aims to summarize our current understanding of the cross-talk between metabolic reprogramming and cytokine responses, and to highlight future potential research topics. Although the focus is placed on viral pathogens, relevant findings from other microbes are integrated to provide an overall picture, particularly when corresponding information on viral infection is lacking. |
| first_indexed | 2024-12-23T06:39:57Z |
| format | Article |
| id | doaj.art-5eeee84ecb6d4291b2796e1094dacafc |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-12-23T06:39:57Z |
| publishDate | 2018-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-5eeee84ecb6d4291b2796e1094dacafc2022-12-21T17:56:43ZengMDPI AGViruses1999-49152018-09-01101052110.3390/v10100521v10100521Interplay between Cellular Metabolism and Cytokine Responses during Viral InfectionShu Zhang0Jessica Carriere1Xiaoxi Lin2Na Xie3Pinghui Feng4Section of Infection and Immunity, Herman Ostrow School of Dentistry, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA 90089-0641, USASection of Infection and Immunity, Herman Ostrow School of Dentistry, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA 90089-0641, USASection of Infection and Immunity, Herman Ostrow School of Dentistry, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA 90089-0641, USASection of Infection and Immunity, Herman Ostrow School of Dentistry, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA 90089-0641, USASection of Infection and Immunity, Herman Ostrow School of Dentistry, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA 90089-0641, USAMetabolism and immune responses are two fundamental biological processes that serve to protect hosts from viral infection. As obligate intracellular pathogens, viruses have evolved diverse strategies to activate metabolism, while inactivating immune responses to achieve maximal reproduction or persistence within their hosts. The two-way virus-host interaction with metabolism and immune responses choreograph cytokine production via reprogramming metabolism of infected cells/hosts. In return, cytokines can affect the metabolism of virus-infected and bystander cells to impede viral replication processes. This review aims to summarize our current understanding of the cross-talk between metabolic reprogramming and cytokine responses, and to highlight future potential research topics. Although the focus is placed on viral pathogens, relevant findings from other microbes are integrated to provide an overall picture, particularly when corresponding information on viral infection is lacking.http://www.mdpi.com/1999-4915/10/10/521metabolic reprogramminginnate immunitycytokine responseimmunometabolism |
| spellingShingle | Shu Zhang Jessica Carriere Xiaoxi Lin Na Xie Pinghui Feng Interplay between Cellular Metabolism and Cytokine Responses during Viral Infection Viruses metabolic reprogramming innate immunity cytokine response immunometabolism |
| title | Interplay between Cellular Metabolism and Cytokine Responses during Viral Infection |
| title_full | Interplay between Cellular Metabolism and Cytokine Responses during Viral Infection |
| title_fullStr | Interplay between Cellular Metabolism and Cytokine Responses during Viral Infection |
| title_full_unstemmed | Interplay between Cellular Metabolism and Cytokine Responses during Viral Infection |
| title_short | Interplay between Cellular Metabolism and Cytokine Responses during Viral Infection |
| title_sort | interplay between cellular metabolism and cytokine responses during viral infection |
| topic | metabolic reprogramming innate immunity cytokine response immunometabolism |
| url | http://www.mdpi.com/1999-4915/10/10/521 |
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