Laboratory indicators for monitoring HIV disease
Immunological monitoring of disease progression following HIV infection and seroconversion illness, latency and AIDS, not only helps in the basic investigation of the natural history of the viral infection in man, but also can assist in prognosis and treatment of AIDS-defining illnesses. However, ou...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Fundação Oswaldo Cruz (FIOCRUZ)
1996-06-01
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| Series: | Memorias do Instituto Oswaldo Cruz |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761996000300020 |
| _version_ | 1797757255287832576 |
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| author | Raul Scott Pereira Matthew Reginald Helbert |
| author_facet | Raul Scott Pereira Matthew Reginald Helbert |
| author_sort | Raul Scott Pereira |
| collection | DOAJ |
| description | Immunological monitoring of disease progression following HIV infection and seroconversion illness, latency and AIDS, not only helps in the basic investigation of the natural history of the viral infection in man, but also can assist in prognosis and treatment of AIDS-defining illnesses. However, outside clinical trials, these tests should be selected and used in clinical practice only if they are validated as relevant and effective. The absolute CD4+ T-helper lymphocyte count, measured by flow cytometry, has emerged as the best available investigation, but needs care in sampling due to diurnal and circadian rhythms, effects of age, pregnancy, therapy, intercurrent infections and technique. Sampling should provide a baseline and trends - monthly intervals initially, then quarterly in uncomplicated cases. Thresholds may be given for counts (e.g. 200/µl) below which prophylaxis against pneumocystis pneumonia should be administered, and repeating persistently low counts (e.g. below 50/µl) is seldom helpful in practice. Serum levels of beta-2 microglobulin, neopterin and immunoglobulins rarely add information. Physicians and laboratories should have testing guidelines based on clinical audit of best practice, based in turn on scientific understanding of the immunological processes involved. |
| first_indexed | 2024-03-12T18:13:14Z |
| format | Article |
| id | doaj.art-5eef6099bf64485ebceb59f40fc26f8c |
| institution | Directory Open Access Journal |
| issn | 0074-0276 1678-8060 |
| language | English |
| last_indexed | 2024-03-12T18:13:14Z |
| publishDate | 1996-06-01 |
| publisher | Fundação Oswaldo Cruz (FIOCRUZ) |
| record_format | Article |
| series | Memorias do Instituto Oswaldo Cruz |
| spelling | doaj.art-5eef6099bf64485ebceb59f40fc26f8c2023-08-02T09:14:11ZengFundação Oswaldo Cruz (FIOCRUZ)Memorias do Instituto Oswaldo Cruz0074-02761678-80601996-06-0191335936210.1590/S0074-02761996000300020Laboratory indicators for monitoring HIV diseaseRaul Scott PereiraMatthew Reginald HelbertImmunological monitoring of disease progression following HIV infection and seroconversion illness, latency and AIDS, not only helps in the basic investigation of the natural history of the viral infection in man, but also can assist in prognosis and treatment of AIDS-defining illnesses. However, outside clinical trials, these tests should be selected and used in clinical practice only if they are validated as relevant and effective. The absolute CD4+ T-helper lymphocyte count, measured by flow cytometry, has emerged as the best available investigation, but needs care in sampling due to diurnal and circadian rhythms, effects of age, pregnancy, therapy, intercurrent infections and technique. Sampling should provide a baseline and trends - monthly intervals initially, then quarterly in uncomplicated cases. Thresholds may be given for counts (e.g. 200/µl) below which prophylaxis against pneumocystis pneumonia should be administered, and repeating persistently low counts (e.g. below 50/µl) is seldom helpful in practice. Serum levels of beta-2 microglobulin, neopterin and immunoglobulins rarely add information. Physicians and laboratories should have testing guidelines based on clinical audit of best practice, based in turn on scientific understanding of the immunological processes involved.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761996000300020T helperAIDSneopterinb2microglobulinaudit |
| spellingShingle | Raul Scott Pereira Matthew Reginald Helbert Laboratory indicators for monitoring HIV disease Memorias do Instituto Oswaldo Cruz T helper AIDS neopterin b2microglobulin audit |
| title | Laboratory indicators for monitoring HIV disease |
| title_full | Laboratory indicators for monitoring HIV disease |
| title_fullStr | Laboratory indicators for monitoring HIV disease |
| title_full_unstemmed | Laboratory indicators for monitoring HIV disease |
| title_short | Laboratory indicators for monitoring HIV disease |
| title_sort | laboratory indicators for monitoring hiv disease |
| topic | T helper AIDS neopterin b2microglobulin audit |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761996000300020 |
| work_keys_str_mv | AT raulscottpereira laboratoryindicatorsformonitoringhivdisease AT matthewreginaldhelbert laboratoryindicatorsformonitoringhivdisease |