Subretinal Transplant of Human Amniotic Membrane in Advanced Age-Related Macular Degeneration
Macular neovascularization (MNV) and geographic atrophy can complicate age-related macular degeneration (AMD) and lead to severe visual acuity reduction. Despite the medical treatments available, with a defect in the retinal pigmented epithelium (RPE) there is no possibility of restoring acceptable...
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MDPI AG
2022-11-01
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| Series: | Life |
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| Online Access: | https://www.mdpi.com/2075-1729/12/12/1998 |
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| author | Tomaso Caporossi Alessandra Scampoli Antonio Baldascino Gloria Gambini Bianca Pacini Lorenzo Governatori Daniela Bacherini Matteo Mario Carlà Emanuele Crincoli Clara Rizzo Raphael Kilian Stanislao Rizzo |
| author_facet | Tomaso Caporossi Alessandra Scampoli Antonio Baldascino Gloria Gambini Bianca Pacini Lorenzo Governatori Daniela Bacherini Matteo Mario Carlà Emanuele Crincoli Clara Rizzo Raphael Kilian Stanislao Rizzo |
| author_sort | Tomaso Caporossi |
| collection | DOAJ |
| description | Macular neovascularization (MNV) and geographic atrophy can complicate age-related macular degeneration (AMD) and lead to severe visual acuity reduction. Despite the medical treatments available, with a defect in the retinal pigmented epithelium (RPE) there is no possibility of restoring acceptable visual acuity. We evaluated postoperative outcomes in patients affected by advanced AMD who underwent subretinal implant of the human amniotic membrane (hAM) as a source of pluripotent stem cells. This retrospective, consecutive, non-randomized interventional study included 23 eyes of 21 patients affected by AMD complicated by MNV, and five eyes of five patients affected by geographic atrophy. All eyes underwent a pars plana vitrectomy, neovascular membrane removal for the MNV group, a subretinal implant of hAM, and gas tamponade, and were followed for 12 months. The primary study outcome was visual acuity improvement. Secondary outcomes were postoperative complications, OCT-angiography parameters correlated with best-corrected visual acuity (BCVA) and MNV recurrence. The mean preoperative BCVA was 1.9 logMAR, and the mean final BCVA value was 1.2 logMAR. In the MNV group, the mean BCVA improved from 1.84 logMAR to 1.26 logMAR, and from 1.84 logMAR to 1.32 logMAR in the geographic atrophy group. No MNV recurrence was evident in 12 months of follow-up. An OCT-angiography scan was used to evaluate the retinal vascularization in the treated eye, which showed a high correlation between BCVA and deep vascular density. This study demonstrates the hAM potential and safety in promoting a partial restoration of retinal function together with an increase in visual acuity. |
| first_indexed | 2024-03-09T16:10:57Z |
| format | Article |
| id | doaj.art-5ef02f547dfe4dee8bfa847340f6dcd5 |
| institution | Directory Open Access Journal |
| issn | 2075-1729 |
| language | English |
| last_indexed | 2024-03-09T16:10:57Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Life |
| spelling | doaj.art-5ef02f547dfe4dee8bfa847340f6dcd52023-11-24T16:11:50ZengMDPI AGLife2075-17292022-11-011212199810.3390/life12121998Subretinal Transplant of Human Amniotic Membrane in Advanced Age-Related Macular DegenerationTomaso Caporossi0Alessandra Scampoli1Antonio Baldascino2Gloria Gambini3Bianca Pacini4Lorenzo Governatori5Daniela Bacherini6Matteo Mario Carlà7Emanuele Crincoli8Clara Rizzo9Raphael Kilian10Stanislao Rizzo11Ophthalmology Unit, “Fondazione Policlinico Universitario A. Gemelli IRCCS”, 00168 Rome, ItalyOphthalmology Unit, “Fondazione Policlinico Universitario A. Gemelli IRCCS”, 00168 Rome, ItalyOphthalmology Unit, “Fondazione Policlinico Universitario A. Gemelli IRCCS”, 00168 Rome, ItalyOphthalmology Unit, “Fondazione Policlinico Universitario A. Gemelli IRCCS”, 00168 Rome, ItalyDepartment of NEUROFARBA, Ophthalmology, University of Florence, Careggi, 50139 Florence, ItalyDepartment of NEUROFARBA, Ophthalmology, University of Florence, Careggi, 50139 Florence, ItalyDepartment of NEUROFARBA, Ophthalmology, University of Florence, Careggi, 50139 Florence, ItalyOphthalmology Unit, “Fondazione Policlinico Universitario A. Gemelli IRCCS”, 00168 Rome, ItalyOphthalmology Unit, “Fondazione Policlinico Universitario A. Gemelli IRCCS”, 00168 Rome, ItalyOphthalmology Unit, Department of Surgical, Medical, Molecular and Critical Area Pathology, University of Pisa, 56122 Pisa, ItalyOphthalmology Unit, University of Verona, 37129 Verona, ItalyOphthalmology Unit, “Fondazione Policlinico Universitario A. Gemelli IRCCS”, 00168 Rome, ItalyMacular neovascularization (MNV) and geographic atrophy can complicate age-related macular degeneration (AMD) and lead to severe visual acuity reduction. Despite the medical treatments available, with a defect in the retinal pigmented epithelium (RPE) there is no possibility of restoring acceptable visual acuity. We evaluated postoperative outcomes in patients affected by advanced AMD who underwent subretinal implant of the human amniotic membrane (hAM) as a source of pluripotent stem cells. This retrospective, consecutive, non-randomized interventional study included 23 eyes of 21 patients affected by AMD complicated by MNV, and five eyes of five patients affected by geographic atrophy. All eyes underwent a pars plana vitrectomy, neovascular membrane removal for the MNV group, a subretinal implant of hAM, and gas tamponade, and were followed for 12 months. The primary study outcome was visual acuity improvement. Secondary outcomes were postoperative complications, OCT-angiography parameters correlated with best-corrected visual acuity (BCVA) and MNV recurrence. The mean preoperative BCVA was 1.9 logMAR, and the mean final BCVA value was 1.2 logMAR. In the MNV group, the mean BCVA improved from 1.84 logMAR to 1.26 logMAR, and from 1.84 logMAR to 1.32 logMAR in the geographic atrophy group. No MNV recurrence was evident in 12 months of follow-up. An OCT-angiography scan was used to evaluate the retinal vascularization in the treated eye, which showed a high correlation between BCVA and deep vascular density. This study demonstrates the hAM potential and safety in promoting a partial restoration of retinal function together with an increase in visual acuity.https://www.mdpi.com/2075-1729/12/12/1998age-related macular degenerationmacular neovascularizationstem cellsregenerative ophthalmologyhuman amniotic membraneOCT-angiography |
| spellingShingle | Tomaso Caporossi Alessandra Scampoli Antonio Baldascino Gloria Gambini Bianca Pacini Lorenzo Governatori Daniela Bacherini Matteo Mario Carlà Emanuele Crincoli Clara Rizzo Raphael Kilian Stanislao Rizzo Subretinal Transplant of Human Amniotic Membrane in Advanced Age-Related Macular Degeneration Life age-related macular degeneration macular neovascularization stem cells regenerative ophthalmology human amniotic membrane OCT-angiography |
| title | Subretinal Transplant of Human Amniotic Membrane in Advanced Age-Related Macular Degeneration |
| title_full | Subretinal Transplant of Human Amniotic Membrane in Advanced Age-Related Macular Degeneration |
| title_fullStr | Subretinal Transplant of Human Amniotic Membrane in Advanced Age-Related Macular Degeneration |
| title_full_unstemmed | Subretinal Transplant of Human Amniotic Membrane in Advanced Age-Related Macular Degeneration |
| title_short | Subretinal Transplant of Human Amniotic Membrane in Advanced Age-Related Macular Degeneration |
| title_sort | subretinal transplant of human amniotic membrane in advanced age related macular degeneration |
| topic | age-related macular degeneration macular neovascularization stem cells regenerative ophthalmology human amniotic membrane OCT-angiography |
| url | https://www.mdpi.com/2075-1729/12/12/1998 |
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