Determination of neurometabolism in patients with mild and moderate cognitive impairments
Objective: to estimate the diagnostic value of neuropower mapping (NPM) and positron emission tomography (PET) and their relationships in the evaluation of neurometabolism in patients with predementia cognitive impairments.Material and methods. The investigation enrolled 125 patients with clinical s...
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| Format: | Article |
| Language: | English |
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Luchevaya Diagnostika, LLC
2016-02-01
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| Series: | Вестник рентгенологии и радиологии |
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| Online Access: | https://www.russianradiology.ru/jour/article/view/12 |
| _version_ | 1797341689196576768 |
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| author | N. N. Mikheev M. V. Zharikova L. V. Eliseeva Yu. V. Borisova |
| author_facet | N. N. Mikheev M. V. Zharikova L. V. Eliseeva Yu. V. Borisova |
| author_sort | N. N. Mikheev |
| collection | DOAJ |
| description | Objective: to estimate the diagnostic value of neuropower mapping (NPM) and positron emission tomography (PET) and their relationships in the evaluation of neurometabolism in patients with predementia cognitive impairments.Material and methods. The investigation enrolled 125 patients with clinical signs of cognitive impairments. The patients were divided into 4 groups: 1) predementia cognitive impairments (PCI) in the presence of cerebrovascular disease (CVD); 2) PCI in the presence of psychoautonomic syndrome (PAS); 3) PCI in the presence of sequels to acute cerebrovascular accident (SCVA); 4) PCI in the presence of toxic, dysmetabolic, hypoxic encephalopathies (TDHEP). All the patients underwent NPM and 55 patients had PET.Results and discussion. NPM and PET revealed neurometabolic disturbances in 100 and 46,3% of cases, respectively. The sensitivity of NPM was significantly higher than that of PET. The highest number of diffuse and diffuse-focal hypometabolism cases (n = 19 (63,3%)) were seen in the CVD and SCVA groups.Conclusion. 1. NPM and PET assess two aspects of brain neurometabolism. 2. PET hypometabolism characterizes either structural organic abnormalities in the brain in the presence SCVA or initial manifestations of the neurodegenerative process. 3. NPM readings characterize the activity, strength of metabolic responses, that is to say, cerebral reactivity. 4. PET readings are important in determining the prognosis of disease and NPM ones are essential in defining drug treatment policy. |
| first_indexed | 2024-03-08T10:22:39Z |
| format | Article |
| id | doaj.art-5ef0d4c05f374a9a9bf6b940254c8b0d |
| institution | Directory Open Access Journal |
| issn | 0042-4676 2619-0478 |
| language | English |
| last_indexed | 2024-03-08T10:22:39Z |
| publishDate | 2016-02-01 |
| publisher | Luchevaya Diagnostika, LLC |
| record_format | Article |
| series | Вестник рентгенологии и радиологии |
| spelling | doaj.art-5ef0d4c05f374a9a9bf6b940254c8b0d2024-01-27T18:38:32ZengLuchevaya Diagnostika, LLCВестник рентгенологии и радиологии0042-46762619-04782016-02-0102152210.20862/0042-4676-2015-0-2-15-2212Determination of neurometabolism in patients with mild and moderate cognitive impairmentsN. N. Mikheev0M. V. Zharikova1L. V. Eliseeva2Yu. V. Borisova3Main Clinical Hospital, Russian Ministry of InteriorMain Clinical Hospital, Russian Ministry of InteriorMain Clinical Hospital, Russian Ministry of InteriorClinical Hospital № 1, Department for Presidential Affairs of the Russian FederationObjective: to estimate the diagnostic value of neuropower mapping (NPM) and positron emission tomography (PET) and their relationships in the evaluation of neurometabolism in patients with predementia cognitive impairments.Material and methods. The investigation enrolled 125 patients with clinical signs of cognitive impairments. The patients were divided into 4 groups: 1) predementia cognitive impairments (PCI) in the presence of cerebrovascular disease (CVD); 2) PCI in the presence of psychoautonomic syndrome (PAS); 3) PCI in the presence of sequels to acute cerebrovascular accident (SCVA); 4) PCI in the presence of toxic, dysmetabolic, hypoxic encephalopathies (TDHEP). All the patients underwent NPM and 55 patients had PET.Results and discussion. NPM and PET revealed neurometabolic disturbances in 100 and 46,3% of cases, respectively. The sensitivity of NPM was significantly higher than that of PET. The highest number of diffuse and diffuse-focal hypometabolism cases (n = 19 (63,3%)) were seen in the CVD and SCVA groups.Conclusion. 1. NPM and PET assess two aspects of brain neurometabolism. 2. PET hypometabolism characterizes either structural organic abnormalities in the brain in the presence SCVA or initial manifestations of the neurodegenerative process. 3. NPM readings characterize the activity, strength of metabolic responses, that is to say, cerebral reactivity. 4. PET readings are important in determining the prognosis of disease and NPM ones are essential in defining drug treatment policy.https://www.russianradiology.ru/jour/article/view/12neuropower mappingpositron emission tomographycognitive impairmentsneurometabolism |
| spellingShingle | N. N. Mikheev M. V. Zharikova L. V. Eliseeva Yu. V. Borisova Determination of neurometabolism in patients with mild and moderate cognitive impairments Вестник рентгенологии и радиологии neuropower mapping positron emission tomography cognitive impairments neurometabolism |
| title | Determination of neurometabolism in patients with mild and moderate cognitive impairments |
| title_full | Determination of neurometabolism in patients with mild and moderate cognitive impairments |
| title_fullStr | Determination of neurometabolism in patients with mild and moderate cognitive impairments |
| title_full_unstemmed | Determination of neurometabolism in patients with mild and moderate cognitive impairments |
| title_short | Determination of neurometabolism in patients with mild and moderate cognitive impairments |
| title_sort | determination of neurometabolism in patients with mild and moderate cognitive impairments |
| topic | neuropower mapping positron emission tomography cognitive impairments neurometabolism |
| url | https://www.russianradiology.ru/jour/article/view/12 |
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