Cross-species functional alignment reveals evolutionary hierarchy within the connectome
Evolution provides an important window into how cortical organization shapes function and vice versa. The complex mosaic of changes in brain morphology and functional organization that have shaped the mammalian cortex during evolution, complicates attempts to chart cortical differences across specie...
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2020-12-01
|
| Series: | NeuroImage |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1053811920308326 |
| _version_ | 1818263608049532928 |
|---|---|
| author | Ting Xu Karl-Heinz Nenning Ernst Schwartz Seok-Jun Hong Joshua T. Vogelstein Alexandros Goulas Damien A. Fair Charles E. Schroeder Daniel S. Margulies Jonny Smallwood Michael P. Milham Georg Langs |
| author_facet | Ting Xu Karl-Heinz Nenning Ernst Schwartz Seok-Jun Hong Joshua T. Vogelstein Alexandros Goulas Damien A. Fair Charles E. Schroeder Daniel S. Margulies Jonny Smallwood Michael P. Milham Georg Langs |
| author_sort | Ting Xu |
| collection | DOAJ |
| description | Evolution provides an important window into how cortical organization shapes function and vice versa. The complex mosaic of changes in brain morphology and functional organization that have shaped the mammalian cortex during evolution, complicates attempts to chart cortical differences across species. It limits our ability to fully appreciate how evolution has shaped our brain, especially in systems associated with unique human cognitive capabilities that lack anatomical homologues in other species. Here, we develop a function-based method for cross-species alignment that enables the quantification of homologous regions between humans and rhesus macaques, even when their location is decoupled from anatomical landmarks. Critically, we find cross-species similarity in functional organization reflects a gradient of evolutionary change that decreases from unimodal systems and culminates with the most pronounced changes in posterior regions of the default mode network (angular gyrus, posterior cingulate and middle temporal cortices). Our findings suggest that the establishment of the default mode network, as the apex of a cognitive hierarchy, has changed in a complex manner during human evolution – even within subnetworks. |
| first_indexed | 2024-12-12T19:21:43Z |
| format | Article |
| id | doaj.art-5ef264ee6f7e418ba8daa2c0327dc606 |
| institution | Directory Open Access Journal |
| issn | 1095-9572 |
| language | English |
| last_indexed | 2024-12-12T19:21:43Z |
| publishDate | 2020-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | NeuroImage |
| spelling | doaj.art-5ef264ee6f7e418ba8daa2c0327dc6062022-12-22T00:14:35ZengElsevierNeuroImage1095-95722020-12-01223117346Cross-species functional alignment reveals evolutionary hierarchy within the connectomeTing Xu0Karl-Heinz Nenning1Ernst Schwartz2Seok-Jun Hong3Joshua T. Vogelstein4Alexandros Goulas5Damien A. Fair6Charles E. Schroeder7Daniel S. Margulies8Jonny Smallwood9Michael P. Milham10Georg Langs11Center for the Developing Brain, Child Mind Institute, New York, NY, USA; Corresponding author.Computational Imaging Research Lab, Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, AustriaComputational Imaging Research Lab, Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, AustriaCenter for the Developing Brain, Child Mind Institute, New York, NY, USADepartment of Biomedical Engineering, Institute for Computational Medicine, Kavli Neuroscience Discovery Institute, Johns Hopkins University, MD, USAInstitute of Computational Neuroscience, University Medical Center Hamburg-Eppendorf, Hamburg University, Hamburg, GermanyAdvanced Imaging Research Center, Oregon Health & Science University, Portland, OR, USACenter for Biomedical Imaging and Neuromodulation, Nathan Kline Institute, Orangeburg, NY, USA; Departments of neurosurgery and Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY, USACentre National de la Recherche Scientifique (CNRS) UMR 7225, Frontlab, Institut du Cerveau et de la Moelle Epinière, Paris, FranceDepartment of Psychology, Queen's University, Kingston, Ontario, Canada; Psychology Department, University of York, York, UKCenter for the Developing Brain, Child Mind Institute, New York, NY, USA; Center for Biomedical Imaging and Neuromodulation, Nathan Kline Institute, Orangeburg, NY, USAComputational Imaging Research Lab, Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Austria; Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, MA, USAEvolution provides an important window into how cortical organization shapes function and vice versa. The complex mosaic of changes in brain morphology and functional organization that have shaped the mammalian cortex during evolution, complicates attempts to chart cortical differences across species. It limits our ability to fully appreciate how evolution has shaped our brain, especially in systems associated with unique human cognitive capabilities that lack anatomical homologues in other species. Here, we develop a function-based method for cross-species alignment that enables the quantification of homologous regions between humans and rhesus macaques, even when their location is decoupled from anatomical landmarks. Critically, we find cross-species similarity in functional organization reflects a gradient of evolutionary change that decreases from unimodal systems and culminates with the most pronounced changes in posterior regions of the default mode network (angular gyrus, posterior cingulate and middle temporal cortices). Our findings suggest that the establishment of the default mode network, as the apex of a cognitive hierarchy, has changed in a complex manner during human evolution – even within subnetworks.http://www.sciencedirect.com/science/article/pii/S1053811920308326Cross-species alignmentJoint embeddingEvolutionHierarchyDefault mode network |
| spellingShingle | Ting Xu Karl-Heinz Nenning Ernst Schwartz Seok-Jun Hong Joshua T. Vogelstein Alexandros Goulas Damien A. Fair Charles E. Schroeder Daniel S. Margulies Jonny Smallwood Michael P. Milham Georg Langs Cross-species functional alignment reveals evolutionary hierarchy within the connectome NeuroImage Cross-species alignment Joint embedding Evolution Hierarchy Default mode network |
| title | Cross-species functional alignment reveals evolutionary hierarchy within the connectome |
| title_full | Cross-species functional alignment reveals evolutionary hierarchy within the connectome |
| title_fullStr | Cross-species functional alignment reveals evolutionary hierarchy within the connectome |
| title_full_unstemmed | Cross-species functional alignment reveals evolutionary hierarchy within the connectome |
| title_short | Cross-species functional alignment reveals evolutionary hierarchy within the connectome |
| title_sort | cross species functional alignment reveals evolutionary hierarchy within the connectome |
| topic | Cross-species alignment Joint embedding Evolution Hierarchy Default mode network |
| url | http://www.sciencedirect.com/science/article/pii/S1053811920308326 |
| work_keys_str_mv | AT tingxu crossspeciesfunctionalalignmentrevealsevolutionaryhierarchywithintheconnectome AT karlheinznenning crossspeciesfunctionalalignmentrevealsevolutionaryhierarchywithintheconnectome AT ernstschwartz crossspeciesfunctionalalignmentrevealsevolutionaryhierarchywithintheconnectome AT seokjunhong crossspeciesfunctionalalignmentrevealsevolutionaryhierarchywithintheconnectome AT joshuatvogelstein crossspeciesfunctionalalignmentrevealsevolutionaryhierarchywithintheconnectome AT alexandrosgoulas crossspeciesfunctionalalignmentrevealsevolutionaryhierarchywithintheconnectome AT damienafair crossspeciesfunctionalalignmentrevealsevolutionaryhierarchywithintheconnectome AT charleseschroeder crossspeciesfunctionalalignmentrevealsevolutionaryhierarchywithintheconnectome AT danielsmargulies crossspeciesfunctionalalignmentrevealsevolutionaryhierarchywithintheconnectome AT jonnysmallwood crossspeciesfunctionalalignmentrevealsevolutionaryhierarchywithintheconnectome AT michaelpmilham crossspeciesfunctionalalignmentrevealsevolutionaryhierarchywithintheconnectome AT georglangs crossspeciesfunctionalalignmentrevealsevolutionaryhierarchywithintheconnectome |