Chemotherapy‐Enabled Colorectal Cancer Immunotherapy of Self‐Delivery Nano‐PROTACs by Inhibiting Tumor Glycolysis and Avoiding Adaptive Immune Resistance

Chemotherapy‐Enabled Colorectal Cancer Immunotherapy of Self‐Delivery Nano‐PROTACs by Inhibiting Tumor Glycolysis and Avoiding Adaptive Immune Resistance

Abstract The chemo‐regulation abilities of chemotherapeutic medications are appealing to address the low immunogenicity, immunosuppressive lactate microenvironment, and adaptive immune resistance of colorectal cancer. In this work, the proteolysis targeting chimera (PROTAC) of BRD4 (dBET57) is found...

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Bibliographic Details
Main Authors: Lin‐Ping Zhao, Rong‐Rong Zheng, Xiao‐Na Rao, Chu‐Yu Huang, Hang‐Yu Zhou, Xi‐Yong Yu, Xue‐Yan Jiang, Shi‐Ying Li
Format: Article
Language:English
Published: Wiley 2024-04-01
Series:Advanced Science
Subjects:
chemotherapy
colorectal cancer
immunotherapy
nano‐PROTACs
self‐delivery
Online Access:https://doi.org/10.1002/advs.202309204

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