Mechanical Considerations of Electrospun Scaffolds for Myocardial Tissue and Regenerative Engineering
Biomaterials to facilitate the restoration of cardiac tissue is of emerging importance. While there are many aspects to consider in the design of biomaterials, mechanical properties can be of particular importance in this dynamically remodeling tissue. This review focuses on one specific processing...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-10-01
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| Series: | Bioengineering |
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| Online Access: | https://www.mdpi.com/2306-5354/7/4/122 |
| _version_ | 1827704902194823168 |
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| author | Michael Nguyen-Truong Yan Vivian Li Zhijie Wang |
| author_facet | Michael Nguyen-Truong Yan Vivian Li Zhijie Wang |
| author_sort | Michael Nguyen-Truong |
| collection | DOAJ |
| description | Biomaterials to facilitate the restoration of cardiac tissue is of emerging importance. While there are many aspects to consider in the design of biomaterials, mechanical properties can be of particular importance in this dynamically remodeling tissue. This review focuses on one specific processing method, electrospinning, that is employed to generate materials with a fibrous microstructure that can be combined with material properties to achieve the desired mechanical behavior. Current methods used to fabricate mechanically relevant micro-/nanofibrous scaffolds, in vivo studies using these scaffolds as therapeutics, and common techniques to characterize the mechanical properties of the scaffolds are covered. We also discuss the discrepancies in the reported elastic modulus for physiological and pathological myocardium in the literature, as well as the emerging area of in vitro mechanobiology studies to investigate the mechanical regulation in cardiac tissue engineering. Lastly, future perspectives and recommendations are offered in order to enhance the understanding of cardiac mechanobiology and foster therapeutic development in myocardial regenerative medicine. |
| first_indexed | 2024-03-10T15:51:43Z |
| format | Article |
| id | doaj.art-5ef8070b7415416c96a6add5773816a6 |
| institution | Directory Open Access Journal |
| issn | 2306-5354 |
| language | English |
| last_indexed | 2024-03-10T15:51:43Z |
| publishDate | 2020-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Bioengineering |
| spelling | doaj.art-5ef8070b7415416c96a6add5773816a62023-11-20T15:58:11ZengMDPI AGBioengineering2306-53542020-10-017412210.3390/bioengineering7040122Mechanical Considerations of Electrospun Scaffolds for Myocardial Tissue and Regenerative EngineeringMichael Nguyen-Truong0Yan Vivian Li1Zhijie Wang2School of Biomedical Engineering, Colorado State University, Fort Collins, CO 80523, USASchool of Biomedical Engineering, Colorado State University, Fort Collins, CO 80523, USASchool of Biomedical Engineering, Colorado State University, Fort Collins, CO 80523, USABiomaterials to facilitate the restoration of cardiac tissue is of emerging importance. While there are many aspects to consider in the design of biomaterials, mechanical properties can be of particular importance in this dynamically remodeling tissue. This review focuses on one specific processing method, electrospinning, that is employed to generate materials with a fibrous microstructure that can be combined with material properties to achieve the desired mechanical behavior. Current methods used to fabricate mechanically relevant micro-/nanofibrous scaffolds, in vivo studies using these scaffolds as therapeutics, and common techniques to characterize the mechanical properties of the scaffolds are covered. We also discuss the discrepancies in the reported elastic modulus for physiological and pathological myocardium in the literature, as well as the emerging area of in vitro mechanobiology studies to investigate the mechanical regulation in cardiac tissue engineering. Lastly, future perspectives and recommendations are offered in order to enhance the understanding of cardiac mechanobiology and foster therapeutic development in myocardial regenerative medicine.https://www.mdpi.com/2306-5354/7/4/122heart failureleft/right ventricleregenerative therapybiomechanicsmechanobiology |
| spellingShingle | Michael Nguyen-Truong Yan Vivian Li Zhijie Wang Mechanical Considerations of Electrospun Scaffolds for Myocardial Tissue and Regenerative Engineering Bioengineering heart failure left/right ventricle regenerative therapy biomechanics mechanobiology |
| title | Mechanical Considerations of Electrospun Scaffolds for Myocardial Tissue and Regenerative Engineering |
| title_full | Mechanical Considerations of Electrospun Scaffolds for Myocardial Tissue and Regenerative Engineering |
| title_fullStr | Mechanical Considerations of Electrospun Scaffolds for Myocardial Tissue and Regenerative Engineering |
| title_full_unstemmed | Mechanical Considerations of Electrospun Scaffolds for Myocardial Tissue and Regenerative Engineering |
| title_short | Mechanical Considerations of Electrospun Scaffolds for Myocardial Tissue and Regenerative Engineering |
| title_sort | mechanical considerations of electrospun scaffolds for myocardial tissue and regenerative engineering |
| topic | heart failure left/right ventricle regenerative therapy biomechanics mechanobiology |
| url | https://www.mdpi.com/2306-5354/7/4/122 |
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