How Poloxamer Addition in Hyaluronic-Acid-Decorated Biodegradable Microparticles Affects Polymer Degradation and Protein Release Kinetics

How Poloxamer Addition in Hyaluronic-Acid-Decorated Biodegradable Microparticles Affects Polymer Degradation and Protein Release Kinetics

Polymeric microparticles (MPs) designed for the intravitreal administration of therapeutic proteins result in a prolonged half-life in the vitreous and can delay or discourage the onset of adverse effects inevitably related to this route of administration. Hence, here we designed MPs composed of a p...

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Bibliographic Details
Main Authors: Teresa Silvestri, Barbara Immirzi, Giovanni Dal Poggetto, Paola Di Donato, Valentina Mollo, Laura Mayol, Marco Biondi
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Applied Sciences
Subjects:
biodegradable
microparticles
ocular drug delivery
PLGA
hyaluronic acid
poloxamers
Online Access:https://www.mdpi.com/2076-3417/11/16/7567

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