Genital chlamydia prevalence in Europe and non-European high income countries: systematic review and meta-analysis.
BACKGROUND:Accurate information about the prevalence of Chlamydia trachomatis is needed to assess national prevention and control measures. METHODS:We systematically reviewed population-based cross-sectional studies that estimated chlamydia prevalence in European Union/European Economic Area (EU/EEA...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2015-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC4304822?pdf=render |
| _version_ | 1811205415974731776 |
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| author | Shelagh M Redmond Karin Alexander-Kisslig Sarah C Woodhall Ingrid V F van den Broek Jan van Bergen Helen Ward Anneli Uusküla Björn Herrmann Berit Andersen Hannelore M Götz Otilia Sfetcu Nicola Low |
| author_facet | Shelagh M Redmond Karin Alexander-Kisslig Sarah C Woodhall Ingrid V F van den Broek Jan van Bergen Helen Ward Anneli Uusküla Björn Herrmann Berit Andersen Hannelore M Götz Otilia Sfetcu Nicola Low |
| author_sort | Shelagh M Redmond |
| collection | DOAJ |
| description | BACKGROUND:Accurate information about the prevalence of Chlamydia trachomatis is needed to assess national prevention and control measures. METHODS:We systematically reviewed population-based cross-sectional studies that estimated chlamydia prevalence in European Union/European Economic Area (EU/EEA) Member States and non-European high income countries from January 1990 to August 2012. We examined results in forest plots, explored heterogeneity using the I² statistic, and conducted random effects meta-analysis if appropriate. Meta-regression was used to examine the relationship between study characteristics and chlamydia prevalence estimates. RESULTS:We included 25 population-based studies from 11 EU/EEA countries and 14 studies from five other high income countries. Four EU/EEA Member States reported on nationally representative surveys of sexually experienced adults aged 18-26 years (response rates 52-71%). In women, chlamydia point prevalence estimates ranged from 3.0-5.3%; the pooled average of these estimates was 3.6% (95% CI 2.4, 4.8, I² 0%). In men, estimates ranged from 2.4-7.3% (pooled average 3.5%; 95% CI 1.9, 5.2, I² 27%). Estimates in EU/EEA Member States were statistically consistent with those in other high income countries (I² 0% for women, 6% for men). There was statistical evidence of an association between survey response rate and estimated chlamydia prevalence; estimates were higher in surveys with lower response rates, (p = 0.003 in women, 0.018 in men). CONCLUSIONS:Population-based surveys that estimate chlamydia prevalence are at risk of participation bias owing to low response rates. Estimates obtained in nationally representative samples of the general population of EU/EEA Member States are similar to estimates from other high income countries. |
| first_indexed | 2024-04-12T03:31:06Z |
| format | Article |
| id | doaj.art-5efb2fd40a6e41048dd0cdb5e97ad27f |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-12T03:31:06Z |
| publishDate | 2015-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-5efb2fd40a6e41048dd0cdb5e97ad27f2022-12-22T03:49:33ZengPublic Library of Science (PLoS)PLoS ONE1932-62032015-01-01101e011575310.1371/journal.pone.0115753Genital chlamydia prevalence in Europe and non-European high income countries: systematic review and meta-analysis.Shelagh M RedmondKarin Alexander-KissligSarah C WoodhallIngrid V F van den BroekJan van BergenHelen WardAnneli UuskülaBjörn HerrmannBerit AndersenHannelore M GötzOtilia SfetcuNicola LowBACKGROUND:Accurate information about the prevalence of Chlamydia trachomatis is needed to assess national prevention and control measures. METHODS:We systematically reviewed population-based cross-sectional studies that estimated chlamydia prevalence in European Union/European Economic Area (EU/EEA) Member States and non-European high income countries from January 1990 to August 2012. We examined results in forest plots, explored heterogeneity using the I² statistic, and conducted random effects meta-analysis if appropriate. Meta-regression was used to examine the relationship between study characteristics and chlamydia prevalence estimates. RESULTS:We included 25 population-based studies from 11 EU/EEA countries and 14 studies from five other high income countries. Four EU/EEA Member States reported on nationally representative surveys of sexually experienced adults aged 18-26 years (response rates 52-71%). In women, chlamydia point prevalence estimates ranged from 3.0-5.3%; the pooled average of these estimates was 3.6% (95% CI 2.4, 4.8, I² 0%). In men, estimates ranged from 2.4-7.3% (pooled average 3.5%; 95% CI 1.9, 5.2, I² 27%). Estimates in EU/EEA Member States were statistically consistent with those in other high income countries (I² 0% for women, 6% for men). There was statistical evidence of an association between survey response rate and estimated chlamydia prevalence; estimates were higher in surveys with lower response rates, (p = 0.003 in women, 0.018 in men). CONCLUSIONS:Population-based surveys that estimate chlamydia prevalence are at risk of participation bias owing to low response rates. Estimates obtained in nationally representative samples of the general population of EU/EEA Member States are similar to estimates from other high income countries.http://europepmc.org/articles/PMC4304822?pdf=render |
| spellingShingle | Shelagh M Redmond Karin Alexander-Kisslig Sarah C Woodhall Ingrid V F van den Broek Jan van Bergen Helen Ward Anneli Uusküla Björn Herrmann Berit Andersen Hannelore M Götz Otilia Sfetcu Nicola Low Genital chlamydia prevalence in Europe and non-European high income countries: systematic review and meta-analysis. PLoS ONE |
| title | Genital chlamydia prevalence in Europe and non-European high income countries: systematic review and meta-analysis. |
| title_full | Genital chlamydia prevalence in Europe and non-European high income countries: systematic review and meta-analysis. |
| title_fullStr | Genital chlamydia prevalence in Europe and non-European high income countries: systematic review and meta-analysis. |
| title_full_unstemmed | Genital chlamydia prevalence in Europe and non-European high income countries: systematic review and meta-analysis. |
| title_short | Genital chlamydia prevalence in Europe and non-European high income countries: systematic review and meta-analysis. |
| title_sort | genital chlamydia prevalence in europe and non european high income countries systematic review and meta analysis |
| url | http://europepmc.org/articles/PMC4304822?pdf=render |
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