VAMP8-mediated MUC2 mucin exocytosis from colonic goblet cells maintains innate intestinal homeostasis
VAMP8 is a secretory pathway protein implicated in mucus secretion. Here the authors describe alterations in intestinal immune state and microbiota composition, as well as increased susceptibility to experimental colitis in mice deficient for VAMP8.
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2019-09-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-019-11811-8 |
| _version_ | 1818841459524108288 |
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| author | Steve Cornick Manish Kumar France Moreau Herbert Gaisano Kris Chadee |
| author_facet | Steve Cornick Manish Kumar France Moreau Herbert Gaisano Kris Chadee |
| author_sort | Steve Cornick |
| collection | DOAJ |
| description | VAMP8 is a secretory pathway protein implicated in mucus secretion. Here the authors describe alterations in intestinal immune state and microbiota composition, as well as increased susceptibility to experimental colitis in mice deficient for VAMP8. |
| first_indexed | 2024-12-19T04:26:25Z |
| format | Article |
| id | doaj.art-5efc315bfa514f489f437ae8d29afae4 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-19T04:26:25Z |
| publishDate | 2019-09-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-5efc315bfa514f489f437ae8d29afae42022-12-21T20:36:00ZengNature PortfolioNature Communications2041-17232019-09-0110111410.1038/s41467-019-11811-8VAMP8-mediated MUC2 mucin exocytosis from colonic goblet cells maintains innate intestinal homeostasisSteve Cornick0Manish Kumar1France Moreau2Herbert Gaisano3Kris Chadee4Department of Microbiology, Immunology and Infectious Diseases, Snyder Institute for Chronic Diseases, University of CalgaryDepartment of Microbiology, Immunology and Infectious Diseases, Snyder Institute for Chronic Diseases, University of CalgaryDepartment of Microbiology, Immunology and Infectious Diseases, Snyder Institute for Chronic Diseases, University of CalgaryDepartments of Medicine and Physiology, University of TorontoDepartment of Microbiology, Immunology and Infectious Diseases, Snyder Institute for Chronic Diseases, University of CalgaryVAMP8 is a secretory pathway protein implicated in mucus secretion. Here the authors describe alterations in intestinal immune state and microbiota composition, as well as increased susceptibility to experimental colitis in mice deficient for VAMP8.https://doi.org/10.1038/s41467-019-11811-8 |
| spellingShingle | Steve Cornick Manish Kumar France Moreau Herbert Gaisano Kris Chadee VAMP8-mediated MUC2 mucin exocytosis from colonic goblet cells maintains innate intestinal homeostasis Nature Communications |
| title | VAMP8-mediated MUC2 mucin exocytosis from colonic goblet cells maintains innate intestinal homeostasis |
| title_full | VAMP8-mediated MUC2 mucin exocytosis from colonic goblet cells maintains innate intestinal homeostasis |
| title_fullStr | VAMP8-mediated MUC2 mucin exocytosis from colonic goblet cells maintains innate intestinal homeostasis |
| title_full_unstemmed | VAMP8-mediated MUC2 mucin exocytosis from colonic goblet cells maintains innate intestinal homeostasis |
| title_short | VAMP8-mediated MUC2 mucin exocytosis from colonic goblet cells maintains innate intestinal homeostasis |
| title_sort | vamp8 mediated muc2 mucin exocytosis from colonic goblet cells maintains innate intestinal homeostasis |
| url | https://doi.org/10.1038/s41467-019-11811-8 |
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