High-Salt Diet Causes Sleep Fragmentation in Young Drosophila Through Circadian Rhythm and Dopaminergic Systems
Salt (sodium chloride) is an essential dietary requirement, but excessive consumption has long-term adverse consequences. A high-salt diet (HSD) increases the risk of chronic diseases such as cardiovascular conditions and diabetes and is also associated with poor sleep quality. Little is known, howe...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2019-11-01
|
| Series: | Frontiers in Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fnins.2019.01271/full |
| _version_ | 1811326703654404096 |
|---|---|
| author | Jiayu Xie Danfeng Wang Shengan Ling Guang Yang Yufeng Yang Wenfeng Chen |
| author_facet | Jiayu Xie Danfeng Wang Shengan Ling Guang Yang Yufeng Yang Wenfeng Chen |
| author_sort | Jiayu Xie |
| collection | DOAJ |
| description | Salt (sodium chloride) is an essential dietary requirement, but excessive consumption has long-term adverse consequences. A high-salt diet (HSD) increases the risk of chronic diseases such as cardiovascular conditions and diabetes and is also associated with poor sleep quality. Little is known, however, about the neural circuit mechanisms that mediate HSD-induced sleep changes. In this study, we sought to identify the effects of HSD on the sleep and related neural circuit mechanisms of Drosophila. Strikingly, we found that HSD causes young Drosophila to exhibit a fragmented sleep phenotype similar to that of normal aging individuals. Importantly, we further showed that HSD slightly impairs circadian rhythms and that the HSD-induced sleep changes are dependent on the circadian rhythm system. In addition, we demonstrated that HSD-induced sleep changes are dopaminergic-system dependent. Together, these results provide insight into how elevated salt in the diet can affect sleep quality. |
| first_indexed | 2024-04-13T14:54:19Z |
| format | Article |
| id | doaj.art-5efc7647c26a44c99ba8b52a411eb418 |
| institution | Directory Open Access Journal |
| issn | 1662-453X |
| language | English |
| last_indexed | 2024-04-13T14:54:19Z |
| publishDate | 2019-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroscience |
| spelling | doaj.art-5efc7647c26a44c99ba8b52a411eb4182022-12-22T02:42:29ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2019-11-011310.3389/fnins.2019.01271492759High-Salt Diet Causes Sleep Fragmentation in Young Drosophila Through Circadian Rhythm and Dopaminergic SystemsJiayu Xie0Danfeng Wang1Shengan Ling2Guang Yang3Yufeng Yang4Wenfeng Chen5Institute of Life Sciences, College of Biological Science and Engineering, Fuzhou University, Fuzhou, ChinaInstitute of Applied Ecology, College of Plant Protection, Fujian Agriculture and Forestry University, Fuzhou, ChinaInstitute of Life Sciences, College of Biological Science and Engineering, Fuzhou University, Fuzhou, ChinaInstitute of Applied Ecology, College of Plant Protection, Fujian Agriculture and Forestry University, Fuzhou, ChinaInstitute of Life Sciences, College of Biological Science and Engineering, Fuzhou University, Fuzhou, ChinaInstitute of Life Sciences, College of Biological Science and Engineering, Fuzhou University, Fuzhou, ChinaSalt (sodium chloride) is an essential dietary requirement, but excessive consumption has long-term adverse consequences. A high-salt diet (HSD) increases the risk of chronic diseases such as cardiovascular conditions and diabetes and is also associated with poor sleep quality. Little is known, however, about the neural circuit mechanisms that mediate HSD-induced sleep changes. In this study, we sought to identify the effects of HSD on the sleep and related neural circuit mechanisms of Drosophila. Strikingly, we found that HSD causes young Drosophila to exhibit a fragmented sleep phenotype similar to that of normal aging individuals. Importantly, we further showed that HSD slightly impairs circadian rhythms and that the HSD-induced sleep changes are dependent on the circadian rhythm system. In addition, we demonstrated that HSD-induced sleep changes are dopaminergic-system dependent. Together, these results provide insight into how elevated salt in the diet can affect sleep quality.https://www.frontiersin.org/article/10.3389/fnins.2019.01271/fullhigh-salt dietDrosophilasleepcircadian rhythmdopaminergic system |
| spellingShingle | Jiayu Xie Danfeng Wang Shengan Ling Guang Yang Yufeng Yang Wenfeng Chen High-Salt Diet Causes Sleep Fragmentation in Young Drosophila Through Circadian Rhythm and Dopaminergic Systems Frontiers in Neuroscience high-salt diet Drosophila sleep circadian rhythm dopaminergic system |
| title | High-Salt Diet Causes Sleep Fragmentation in Young Drosophila Through Circadian Rhythm and Dopaminergic Systems |
| title_full | High-Salt Diet Causes Sleep Fragmentation in Young Drosophila Through Circadian Rhythm and Dopaminergic Systems |
| title_fullStr | High-Salt Diet Causes Sleep Fragmentation in Young Drosophila Through Circadian Rhythm and Dopaminergic Systems |
| title_full_unstemmed | High-Salt Diet Causes Sleep Fragmentation in Young Drosophila Through Circadian Rhythm and Dopaminergic Systems |
| title_short | High-Salt Diet Causes Sleep Fragmentation in Young Drosophila Through Circadian Rhythm and Dopaminergic Systems |
| title_sort | high salt diet causes sleep fragmentation in young drosophila through circadian rhythm and dopaminergic systems |
| topic | high-salt diet Drosophila sleep circadian rhythm dopaminergic system |
| url | https://www.frontiersin.org/article/10.3389/fnins.2019.01271/full |
| work_keys_str_mv | AT jiayuxie highsaltdietcausessleepfragmentationinyoungdrosophilathroughcircadianrhythmanddopaminergicsystems AT danfengwang highsaltdietcausessleepfragmentationinyoungdrosophilathroughcircadianrhythmanddopaminergicsystems AT shenganling highsaltdietcausessleepfragmentationinyoungdrosophilathroughcircadianrhythmanddopaminergicsystems AT guangyang highsaltdietcausessleepfragmentationinyoungdrosophilathroughcircadianrhythmanddopaminergicsystems AT yufengyang highsaltdietcausessleepfragmentationinyoungdrosophilathroughcircadianrhythmanddopaminergicsystems AT wenfengchen highsaltdietcausessleepfragmentationinyoungdrosophilathroughcircadianrhythmanddopaminergicsystems |