Recent Advances in the Management of Clear Cell Renal Cell Carcinoma: Novel Biomarkers and Targeted Therapies
Renal cell carcinoma (RCC) belongs to a heterogenous cancer group arising from renal tubular epithelial cells. Among RCC subtypes, clear cell renal cell carcinoma (ccRCC) is the most common variant, characterized by high aggressiveness, invasiveness and metastatic potential, features that lead to po...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-06-01
|
| Series: | Cancers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6694/15/12/3207 |
| _version_ | 1797406235509653504 |
|---|---|
| author | Valentina Schiavoni Roberto Campagna Valentina Pozzi Monia Cecati Giulio Milanese Davide Sartini Eleonora Salvolini Andrea Benedetto Galosi Monica Emanuelli |
| author_facet | Valentina Schiavoni Roberto Campagna Valentina Pozzi Monia Cecati Giulio Milanese Davide Sartini Eleonora Salvolini Andrea Benedetto Galosi Monica Emanuelli |
| author_sort | Valentina Schiavoni |
| collection | DOAJ |
| description | Renal cell carcinoma (RCC) belongs to a heterogenous cancer group arising from renal tubular epithelial cells. Among RCC subtypes, clear cell renal cell carcinoma (ccRCC) is the most common variant, characterized by high aggressiveness, invasiveness and metastatic potential, features that lead to poor prognosis and high mortality rate. In addition, diagnosis of kidney cancer is incidental in the majority of cases, and this results in a late diagnosis, when the stage of the disease is advanced and the tumor has already metastasized. Furthermore, ccRCC treatment is complicated by its strong resistance to chemo- and radiotherapy. Therefore, there is active ongoing research focused on identifying novel biomarkers which could be useful for assessing a better prognosis, as well as new molecules which could be used for targeted therapy. In this light, several novel targeted therapies have been shown to be effective in prolonging the overall survival of ccRCC patients. Thus, the aim of this review is to analyze the actual state-of-the-art on ccRCC diagnosis, prognosis and therapeutic options, while also reporting the recent advances in novel biomarker discoveries, which could be exploited for a better prognosis or for targeted therapy. |
| first_indexed | 2024-03-09T03:23:28Z |
| format | Article |
| id | doaj.art-5efd13646d764205bb35ce64058937e7 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-09T03:23:28Z |
| publishDate | 2023-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-5efd13646d764205bb35ce64058937e72023-12-03T15:05:28ZengMDPI AGCancers2072-66942023-06-011512320710.3390/cancers15123207Recent Advances in the Management of Clear Cell Renal Cell Carcinoma: Novel Biomarkers and Targeted TherapiesValentina Schiavoni0Roberto Campagna1Valentina Pozzi2Monia Cecati3Giulio Milanese4Davide Sartini5Eleonora Salvolini6Andrea Benedetto Galosi7Monica Emanuelli8Department of Clinical Sciences, Polytechnic University of Marche, 60020 Ancona, ItalyDepartment of Clinical Sciences, Polytechnic University of Marche, 60020 Ancona, ItalyDepartment of Clinical Sciences, Polytechnic University of Marche, 60020 Ancona, ItalyDepartment of Clinical Sciences, Polytechnic University of Marche, 60020 Ancona, ItalyDepartment of Clinical Sciences, Polytechnic University of Marche, 60020 Ancona, ItalyDepartment of Clinical Sciences, Polytechnic University of Marche, 60020 Ancona, ItalyDepartment of Clinical Sciences, Polytechnic University of Marche, 60020 Ancona, ItalyDepartment of Clinical Sciences, Polytechnic University of Marche, 60020 Ancona, ItalyDepartment of Clinical Sciences, Polytechnic University of Marche, 60020 Ancona, ItalyRenal cell carcinoma (RCC) belongs to a heterogenous cancer group arising from renal tubular epithelial cells. Among RCC subtypes, clear cell renal cell carcinoma (ccRCC) is the most common variant, characterized by high aggressiveness, invasiveness and metastatic potential, features that lead to poor prognosis and high mortality rate. In addition, diagnosis of kidney cancer is incidental in the majority of cases, and this results in a late diagnosis, when the stage of the disease is advanced and the tumor has already metastasized. Furthermore, ccRCC treatment is complicated by its strong resistance to chemo- and radiotherapy. Therefore, there is active ongoing research focused on identifying novel biomarkers which could be useful for assessing a better prognosis, as well as new molecules which could be used for targeted therapy. In this light, several novel targeted therapies have been shown to be effective in prolonging the overall survival of ccRCC patients. Thus, the aim of this review is to analyze the actual state-of-the-art on ccRCC diagnosis, prognosis and therapeutic options, while also reporting the recent advances in novel biomarker discoveries, which could be exploited for a better prognosis or for targeted therapy.https://www.mdpi.com/2072-6694/15/12/3207renal cell carcinomaclear cell renal cell carcinomabiomarkerprognosistherapy |
| spellingShingle | Valentina Schiavoni Roberto Campagna Valentina Pozzi Monia Cecati Giulio Milanese Davide Sartini Eleonora Salvolini Andrea Benedetto Galosi Monica Emanuelli Recent Advances in the Management of Clear Cell Renal Cell Carcinoma: Novel Biomarkers and Targeted Therapies Cancers renal cell carcinoma clear cell renal cell carcinoma biomarker prognosis therapy |
| title | Recent Advances in the Management of Clear Cell Renal Cell Carcinoma: Novel Biomarkers and Targeted Therapies |
| title_full | Recent Advances in the Management of Clear Cell Renal Cell Carcinoma: Novel Biomarkers and Targeted Therapies |
| title_fullStr | Recent Advances in the Management of Clear Cell Renal Cell Carcinoma: Novel Biomarkers and Targeted Therapies |
| title_full_unstemmed | Recent Advances in the Management of Clear Cell Renal Cell Carcinoma: Novel Biomarkers and Targeted Therapies |
| title_short | Recent Advances in the Management of Clear Cell Renal Cell Carcinoma: Novel Biomarkers and Targeted Therapies |
| title_sort | recent advances in the management of clear cell renal cell carcinoma novel biomarkers and targeted therapies |
| topic | renal cell carcinoma clear cell renal cell carcinoma biomarker prognosis therapy |
| url | https://www.mdpi.com/2072-6694/15/12/3207 |
| work_keys_str_mv | AT valentinaschiavoni recentadvancesinthemanagementofclearcellrenalcellcarcinomanovelbiomarkersandtargetedtherapies AT robertocampagna recentadvancesinthemanagementofclearcellrenalcellcarcinomanovelbiomarkersandtargetedtherapies AT valentinapozzi recentadvancesinthemanagementofclearcellrenalcellcarcinomanovelbiomarkersandtargetedtherapies AT moniacecati recentadvancesinthemanagementofclearcellrenalcellcarcinomanovelbiomarkersandtargetedtherapies AT giuliomilanese recentadvancesinthemanagementofclearcellrenalcellcarcinomanovelbiomarkersandtargetedtherapies AT davidesartini recentadvancesinthemanagementofclearcellrenalcellcarcinomanovelbiomarkersandtargetedtherapies AT eleonorasalvolini recentadvancesinthemanagementofclearcellrenalcellcarcinomanovelbiomarkersandtargetedtherapies AT andreabenedettogalosi recentadvancesinthemanagementofclearcellrenalcellcarcinomanovelbiomarkersandtargetedtherapies AT monicaemanuelli recentadvancesinthemanagementofclearcellrenalcellcarcinomanovelbiomarkersandtargetedtherapies |