Normalization of one-channel microarrays for identification of organisms
Microarrays are widely used in gene expression analysis, but there are further areas they can be applied to, like e.g. the identification of organisms. To interpret and compare the results of microarray experiments it is necessary to standardize the data. In this context standardization is referred...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | deu |
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German Medical Science GMS Publishing House
2007-03-01
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| Series: | GMS Medizinische Informatik, Biometrie und Epidemiologie |
| Subjects: | |
| Online Access: | http://www.egms.de/en/journals/mibe/2007-3/mibe000054.shtml |
| _version_ | 1818259624838561792 |
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| author | Zierer, Astrid Reineke, Achim Drutschmann, Denja Blohm, Dietmar Pigeot, Iris |
| author_facet | Zierer, Astrid Reineke, Achim Drutschmann, Denja Blohm, Dietmar Pigeot, Iris |
| author_sort | Zierer, Astrid |
| collection | DOAJ |
| description | Microarrays are widely used in gene expression analysis, but there are further areas they can be applied to, like e.g. the identification of organisms. To interpret and compare the results of microarray experiments it is necessary to standardize the data. In this context standardization is referred to as normalization. We present data derived from a microarray experiment aiming to identify different subtypes of the hepatitis C virus. Most of the methods developed to normalize microarray data are focused on gene expression analysis. Their use for the identification of organisms is restricted and needs adaption for the special requirements. Based on our data setting, we present several possibilities how to modify the existing methods and deal with the specific conditions. |
| first_indexed | 2024-12-12T18:18:24Z |
| format | Article |
| id | doaj.art-5efd3febfffa49cfbbdc6788d1d50dfe |
| institution | Directory Open Access Journal |
| issn | 1860-9171 |
| language | deu |
| last_indexed | 2024-12-12T18:18:24Z |
| publishDate | 2007-03-01 |
| publisher | German Medical Science GMS Publishing House |
| record_format | Article |
| series | GMS Medizinische Informatik, Biometrie und Epidemiologie |
| spelling | doaj.art-5efd3febfffa49cfbbdc6788d1d50dfe2022-12-22T00:16:13ZdeuGerman Medical Science GMS Publishing HouseGMS Medizinische Informatik, Biometrie und Epidemiologie1860-91712007-03-0131Doc06Normalization of one-channel microarrays for identification of organismsZierer, AstridReineke, AchimDrutschmann, DenjaBlohm, DietmarPigeot, IrisMicroarrays are widely used in gene expression analysis, but there are further areas they can be applied to, like e.g. the identification of organisms. To interpret and compare the results of microarray experiments it is necessary to standardize the data. In this context standardization is referred to as normalization. We present data derived from a microarray experiment aiming to identify different subtypes of the hepatitis C virus. Most of the methods developed to normalize microarray data are focused on gene expression analysis. Their use for the identification of organisms is restricted and needs adaption for the special requirements. Based on our data setting, we present several possibilities how to modify the existing methods and deal with the specific conditions.http://www.egms.de/en/journals/mibe/2007-3/mibe000054.shtmlnormalizationone-channel microarraysidentification of organismsloess |
| spellingShingle | Zierer, Astrid Reineke, Achim Drutschmann, Denja Blohm, Dietmar Pigeot, Iris Normalization of one-channel microarrays for identification of organisms GMS Medizinische Informatik, Biometrie und Epidemiologie normalization one-channel microarrays identification of organisms loess |
| title | Normalization of one-channel microarrays for identification of organisms |
| title_full | Normalization of one-channel microarrays for identification of organisms |
| title_fullStr | Normalization of one-channel microarrays for identification of organisms |
| title_full_unstemmed | Normalization of one-channel microarrays for identification of organisms |
| title_short | Normalization of one-channel microarrays for identification of organisms |
| title_sort | normalization of one channel microarrays for identification of organisms |
| topic | normalization one-channel microarrays identification of organisms loess |
| url | http://www.egms.de/en/journals/mibe/2007-3/mibe000054.shtml |
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