Organocatalysts for enantioselective synthesis of fine chemicals: definitions, trends and developments
Abstract Organocatalysis, that is the use of small organic molecules to catalyze organic transformations, has been included among the most successful concepts in asymmetric catalysis, and it has been used for the enantioselective construction of C–C, C–N, C–O, C–S, C–P and C–halide bonds. Since the...
| Format: | Article |
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| Language: | English |
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ScienceOpen
2015-06-01
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| Series: | ScienceOpen Research |
| Online Access: | https://www.scienceopen.com/document?vid=8e6b1b2d-670e-45ff-a11f-b7bbc31f38e5 |
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Abstract
Organocatalysis, that is the use of small organic molecules to catalyze organic transformations, has been included among the most successful concepts in asymmetric catalysis, and it has been used for the enantioselective construction of C–C, C–N, C–O, C–S, C–P and C–halide bonds. Since the seminal works in early 2000, the scientific community has been paying an ever-growing attention to the use of organocatalysts for the synthesis, with high yields and remarkable stereoselectivities, of optically active fine chemicals of interest for the pharmaceutical industry. A brief overview is here presented about the two main classes of organocatalysis which are respectively characterized by covalent and non-covalent activation of the substrate. More detailed information about non-covalent interactions for organocatalysis are given. Finally, some successful examples of heterogenisation of organocatalysts are also discussed, in the view of a potential industrial exploitation.
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| first_indexed | 2024-04-10T07:49:49Z |
| format | Article |
| id | doaj.art-5efd7589caa04896972331079bcc8f22 |
| institution | Directory Open Access Journal |
| issn | 2199-1006 |
| language | English |
| last_indexed | 2025-03-20T05:43:13Z |
| publishDate | 2015-06-01 |
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| spelling | doaj.art-5efd7589caa04896972331079bcc8f222024-10-03T04:31:15ZengScienceOpenScienceOpen Research2199-10062015-06-0110.14293/S2199-1006.1.SOR-CHEM.AGZIIB.v3Organocatalysts for enantioselective synthesis of fine chemicals: definitions, trends and developments Abstract Organocatalysis, that is the use of small organic molecules to catalyze organic transformations, has been included among the most successful concepts in asymmetric catalysis, and it has been used for the enantioselective construction of C–C, C–N, C–O, C–S, C–P and C–halide bonds. Since the seminal works in early 2000, the scientific community has been paying an ever-growing attention to the use of organocatalysts for the synthesis, with high yields and remarkable stereoselectivities, of optically active fine chemicals of interest for the pharmaceutical industry. A brief overview is here presented about the two main classes of organocatalysis which are respectively characterized by covalent and non-covalent activation of the substrate. More detailed information about non-covalent interactions for organocatalysis are given. Finally, some successful examples of heterogenisation of organocatalysts are also discussed, in the view of a potential industrial exploitation. https://www.scienceopen.com/document?vid=8e6b1b2d-670e-45ff-a11f-b7bbc31f38e5 |
| spellingShingle | Organocatalysts for enantioselective synthesis of fine chemicals: definitions, trends and developments ScienceOpen Research |
| title | Organocatalysts for enantioselective synthesis of fine chemicals: definitions, trends and developments |
| title_full | Organocatalysts for enantioselective synthesis of fine chemicals: definitions, trends and developments |
| title_fullStr | Organocatalysts for enantioselective synthesis of fine chemicals: definitions, trends and developments |
| title_full_unstemmed | Organocatalysts for enantioselective synthesis of fine chemicals: definitions, trends and developments |
| title_short | Organocatalysts for enantioselective synthesis of fine chemicals: definitions, trends and developments |
| title_sort | organocatalysts for enantioselective synthesis of fine chemicals definitions trends and developments |
| url | https://www.scienceopen.com/document?vid=8e6b1b2d-670e-45ff-a11f-b7bbc31f38e5 |