Ugonin L inhibits osteoclast formation and promotes osteoclast apoptosis by inhibiting the MAPK and NF-κB pathways
Bone loss is a major issue for patients with osteoporosis, arthritis, periodontitis, and bone metastasis; however, anti-resorption drugs used to treat bone loss have been linked to a variety of adverse effects. Helminthostachys zeylanica (L.) Hook, belonging to the family Ophioglossaceae, is commonl...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-10-01
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| Series: | Biomedicine & Pharmacotherapy |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0753332223011903 |
| _version_ | 1797686862302674944 |
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| author | Chun-Lin Liu Trung-Loc Ho Shuen-Yih Fang Jeng-Hung Guo Chih-Ying Wu Yi-Chin Fong Chih-Chuang Liaw Chih-Hsin Tang |
| author_facet | Chun-Lin Liu Trung-Loc Ho Shuen-Yih Fang Jeng-Hung Guo Chih-Ying Wu Yi-Chin Fong Chih-Chuang Liaw Chih-Hsin Tang |
| author_sort | Chun-Lin Liu |
| collection | DOAJ |
| description | Bone loss is a major issue for patients with osteoporosis, arthritis, periodontitis, and bone metastasis; however, anti-resorption drugs used to treat bone loss have been linked to a variety of adverse effects. Helminthostachys zeylanica (L.) Hook, belonging to the family Ophioglossaceae, is commonly used in traditional Chinese medicine to treat inflammation and liver problems. In the current study, ugonin L extracted from H. zeylanica was shown to reduce the receptor activator of nuclear factor kappa beta ligand (RANKL)-induced osteoclastogenesis in RAW264.7 cells in a concentration-dependent manner. Ugonin L treatment also inhibited the mRNA expression of osteoclast markers. Ugonin L was also shown to promote cell apoptosis in mature osteoclasts and suppress RANKL-induced ERK, p38, JNK, and NF-κB activation. Taken together, ugonin L appears to be a promising candidate for the development of novel anti-resorption therapies. |
| first_indexed | 2024-03-12T01:10:43Z |
| format | Article |
| id | doaj.art-5efebeddfc8d467ab3f209607e6fab1e |
| institution | Directory Open Access Journal |
| issn | 0753-3322 |
| language | English |
| last_indexed | 2024-03-12T01:10:43Z |
| publishDate | 2023-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biomedicine & Pharmacotherapy |
| spelling | doaj.art-5efebeddfc8d467ab3f209607e6fab1e2023-09-14T04:52:53ZengElsevierBiomedicine & Pharmacotherapy0753-33222023-10-01166115392Ugonin L inhibits osteoclast formation and promotes osteoclast apoptosis by inhibiting the MAPK and NF-κB pathwaysChun-Lin Liu0Trung-Loc Ho1Shuen-Yih Fang2Jeng-Hung Guo3Chih-Ying Wu4Yi-Chin Fong5Chih-Chuang Liaw6Chih-Hsin Tang7Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan; Department of Neurosurgery, China Medical University Hospital, Taichung, TaiwanGraduate Institute of Biomedical Sciences, China Medical University, Taichung, TaiwanDepartment of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung, TaiwanGraduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan; Department of Neurosurgery, China Medical University Hospital, Taichung, TaiwanDepartment of Neurosurgery, China Medical University Hospital, Taichung, Taiwan; Graduate Institute of Integrated Medicine, China Medical University, Taiwan; Department of Neurosurgery, China Medical University Hsinchu Hospital, Hsinchu, TaiwanDepartment of Sports Medicine, College of Health Care, China Medical University, Taichung, Taiwan; Department of Orthopedic Surgery, China Medical University Hospital, Taichung, Taiwan; Department of Orthopedic Surgery, China Medical University Beigang Hospital, Yunlin, TaiwanDepartment of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung, Taiwan; Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung, Taiwan; Corresponding author at: Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung, Taiwan.Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan; Department of Pharmacology, School of Medicine, China Medical University, Taichung, Taiwan; Chinese Medicine Research Center, China Medical University, Taichung, Taiwan; Department of Medical Laboratory Science and Biotechnology, College of Medical and Health Science, Asia University, Taichung, Taiwan; Department of Medical Research, China Medical University Hsinchu Hospital, Hsinchu, Taiwan; Corresponding author at: Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan.Bone loss is a major issue for patients with osteoporosis, arthritis, periodontitis, and bone metastasis; however, anti-resorption drugs used to treat bone loss have been linked to a variety of adverse effects. Helminthostachys zeylanica (L.) Hook, belonging to the family Ophioglossaceae, is commonly used in traditional Chinese medicine to treat inflammation and liver problems. In the current study, ugonin L extracted from H. zeylanica was shown to reduce the receptor activator of nuclear factor kappa beta ligand (RANKL)-induced osteoclastogenesis in RAW264.7 cells in a concentration-dependent manner. Ugonin L treatment also inhibited the mRNA expression of osteoclast markers. Ugonin L was also shown to promote cell apoptosis in mature osteoclasts and suppress RANKL-induced ERK, p38, JNK, and NF-κB activation. Taken together, ugonin L appears to be a promising candidate for the development of novel anti-resorption therapies.http://www.sciencedirect.com/science/article/pii/S0753332223011903Ugonin LOsteoclastRANKLBone resorptionApoptosis |
| spellingShingle | Chun-Lin Liu Trung-Loc Ho Shuen-Yih Fang Jeng-Hung Guo Chih-Ying Wu Yi-Chin Fong Chih-Chuang Liaw Chih-Hsin Tang Ugonin L inhibits osteoclast formation and promotes osteoclast apoptosis by inhibiting the MAPK and NF-κB pathways Biomedicine & Pharmacotherapy Ugonin L Osteoclast RANKL Bone resorption Apoptosis |
| title | Ugonin L inhibits osteoclast formation and promotes osteoclast apoptosis by inhibiting the MAPK and NF-κB pathways |
| title_full | Ugonin L inhibits osteoclast formation and promotes osteoclast apoptosis by inhibiting the MAPK and NF-κB pathways |
| title_fullStr | Ugonin L inhibits osteoclast formation and promotes osteoclast apoptosis by inhibiting the MAPK and NF-κB pathways |
| title_full_unstemmed | Ugonin L inhibits osteoclast formation and promotes osteoclast apoptosis by inhibiting the MAPK and NF-κB pathways |
| title_short | Ugonin L inhibits osteoclast formation and promotes osteoclast apoptosis by inhibiting the MAPK and NF-κB pathways |
| title_sort | ugonin l inhibits osteoclast formation and promotes osteoclast apoptosis by inhibiting the mapk and nf κb pathways |
| topic | Ugonin L Osteoclast RANKL Bone resorption Apoptosis |
| url | http://www.sciencedirect.com/science/article/pii/S0753332223011903 |
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