Clinical Outcomes of Patients with Resected Oral Cavity Cancer and Simultaneous Second Primary Malignancies.
Simultaneous second primary tumors (SSPT) are not uncommon in patients with oral cavity squamous cell carcinoma (OSCC) living in areas where the habit of betel quid chewing is widespread. We sought to identify the main prognostic factors in OSCC patients with SSPT and incorporate them into a risk st...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2015-01-01
|
| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC4559414?pdf=render |
| _version_ | 1811343630617542656 |
|---|---|
| author | Chun-Ta Liao Kang-Hsing Fan Chung-Jan Kang Chien-Yu Lin Joseph Tung-Chieh Chang Ngan-Ming Tsang Bing-Shen Huang Yin-Kai Chao Li-Yu Lee Chuen Hsueh Hung-Ming Wang Chi-Ting Liau Cheng-Lung Hsu Chia-Hsun Hsieh Shu-Hang Ng Chih-Hung Lin Chung-Kan Tsao Tuan-Jen Fang Shiang-Fu Huang Kai-Ping Chang Tzu-Chen Yen |
| author_facet | Chun-Ta Liao Kang-Hsing Fan Chung-Jan Kang Chien-Yu Lin Joseph Tung-Chieh Chang Ngan-Ming Tsang Bing-Shen Huang Yin-Kai Chao Li-Yu Lee Chuen Hsueh Hung-Ming Wang Chi-Ting Liau Cheng-Lung Hsu Chia-Hsun Hsieh Shu-Hang Ng Chih-Hung Lin Chung-Kan Tsao Tuan-Jen Fang Shiang-Fu Huang Kai-Ping Chang Tzu-Chen Yen |
| author_sort | Chun-Ta Liao |
| collection | DOAJ |
| description | Simultaneous second primary tumors (SSPT) are not uncommon in patients with oral cavity squamous cell carcinoma (OSCC) living in areas where the habit of betel quid chewing is widespread. We sought to identify the main prognostic factors in OSCC patients with SSPT and incorporate them into a risk stratification scheme.A total of 1822 consecutive patients with primary OSCC treated between January 1996 and February 2014 were analyzed for the presence of SSPT. The 18-month and 5-year overall survival (OS) rates served as the main outcome measures.Of the 1822 patients, 77 (4%) were found to have SSPT (i.e, two malignancies identified within one month of each other). The 18-month and 5-year OS rates in patients without SSPT and with SSPT were 82% and 69%, and 72% and 53%, respectively (p = 0.0063). Patients with SSPT were further divided into patients with either esophageal cancer or hepatocellular carcinoma (eso-HCC subgroup, n = 8) and other tumors (NO eso-HCC subgroup, n = 69). After multivariate analysis, neck nodal extracapsular spread (ECS, n = 18) and the presence of eso-HCC were identified as independent adverse prognostic factors. The 18-month OS rates of SSPT patients with both eso-HCC and ECS (n = 5) vs. the remaining patients (n = 72) were 0% and 78%, respectively (p < 0.0001).OSCC patients with neck nodal ECS and esophageal cancer or hepatocellular carcinoma as SSPT have a dismal short-term prognosis. |
| first_indexed | 2024-04-13T19:32:20Z |
| format | Article |
| id | doaj.art-5eff354902cf4814b77c805d6cbc0ee3 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-13T19:32:20Z |
| publishDate | 2015-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-5eff354902cf4814b77c805d6cbc0ee32022-12-22T02:33:08ZengPublic Library of Science (PLoS)PLoS ONE1932-62032015-01-01109e013691810.1371/journal.pone.0136918Clinical Outcomes of Patients with Resected Oral Cavity Cancer and Simultaneous Second Primary Malignancies.Chun-Ta LiaoKang-Hsing FanChung-Jan KangChien-Yu LinJoseph Tung-Chieh ChangNgan-Ming TsangBing-Shen HuangYin-Kai ChaoLi-Yu LeeChuen HsuehHung-Ming WangChi-Ting LiauCheng-Lung HsuChia-Hsun HsiehShu-Hang NgChih-Hung LinChung-Kan TsaoTuan-Jen FangShiang-Fu HuangKai-Ping ChangTzu-Chen YenSimultaneous second primary tumors (SSPT) are not uncommon in patients with oral cavity squamous cell carcinoma (OSCC) living in areas where the habit of betel quid chewing is widespread. We sought to identify the main prognostic factors in OSCC patients with SSPT and incorporate them into a risk stratification scheme.A total of 1822 consecutive patients with primary OSCC treated between January 1996 and February 2014 were analyzed for the presence of SSPT. The 18-month and 5-year overall survival (OS) rates served as the main outcome measures.Of the 1822 patients, 77 (4%) were found to have SSPT (i.e, two malignancies identified within one month of each other). The 18-month and 5-year OS rates in patients without SSPT and with SSPT were 82% and 69%, and 72% and 53%, respectively (p = 0.0063). Patients with SSPT were further divided into patients with either esophageal cancer or hepatocellular carcinoma (eso-HCC subgroup, n = 8) and other tumors (NO eso-HCC subgroup, n = 69). After multivariate analysis, neck nodal extracapsular spread (ECS, n = 18) and the presence of eso-HCC were identified as independent adverse prognostic factors. The 18-month OS rates of SSPT patients with both eso-HCC and ECS (n = 5) vs. the remaining patients (n = 72) were 0% and 78%, respectively (p < 0.0001).OSCC patients with neck nodal ECS and esophageal cancer or hepatocellular carcinoma as SSPT have a dismal short-term prognosis.http://europepmc.org/articles/PMC4559414?pdf=render |
| spellingShingle | Chun-Ta Liao Kang-Hsing Fan Chung-Jan Kang Chien-Yu Lin Joseph Tung-Chieh Chang Ngan-Ming Tsang Bing-Shen Huang Yin-Kai Chao Li-Yu Lee Chuen Hsueh Hung-Ming Wang Chi-Ting Liau Cheng-Lung Hsu Chia-Hsun Hsieh Shu-Hang Ng Chih-Hung Lin Chung-Kan Tsao Tuan-Jen Fang Shiang-Fu Huang Kai-Ping Chang Tzu-Chen Yen Clinical Outcomes of Patients with Resected Oral Cavity Cancer and Simultaneous Second Primary Malignancies. PLoS ONE |
| title | Clinical Outcomes of Patients with Resected Oral Cavity Cancer and Simultaneous Second Primary Malignancies. |
| title_full | Clinical Outcomes of Patients with Resected Oral Cavity Cancer and Simultaneous Second Primary Malignancies. |
| title_fullStr | Clinical Outcomes of Patients with Resected Oral Cavity Cancer and Simultaneous Second Primary Malignancies. |
| title_full_unstemmed | Clinical Outcomes of Patients with Resected Oral Cavity Cancer and Simultaneous Second Primary Malignancies. |
| title_short | Clinical Outcomes of Patients with Resected Oral Cavity Cancer and Simultaneous Second Primary Malignancies. |
| title_sort | clinical outcomes of patients with resected oral cavity cancer and simultaneous second primary malignancies |
| url | http://europepmc.org/articles/PMC4559414?pdf=render |
| work_keys_str_mv | AT chuntaliao clinicaloutcomesofpatientswithresectedoralcavitycancerandsimultaneoussecondprimarymalignancies AT kanghsingfan clinicaloutcomesofpatientswithresectedoralcavitycancerandsimultaneoussecondprimarymalignancies AT chungjankang clinicaloutcomesofpatientswithresectedoralcavitycancerandsimultaneoussecondprimarymalignancies AT chienyulin clinicaloutcomesofpatientswithresectedoralcavitycancerandsimultaneoussecondprimarymalignancies AT josephtungchiehchang clinicaloutcomesofpatientswithresectedoralcavitycancerandsimultaneoussecondprimarymalignancies AT nganmingtsang clinicaloutcomesofpatientswithresectedoralcavitycancerandsimultaneoussecondprimarymalignancies AT bingshenhuang clinicaloutcomesofpatientswithresectedoralcavitycancerandsimultaneoussecondprimarymalignancies AT yinkaichao clinicaloutcomesofpatientswithresectedoralcavitycancerandsimultaneoussecondprimarymalignancies AT liyulee clinicaloutcomesofpatientswithresectedoralcavitycancerandsimultaneoussecondprimarymalignancies AT chuenhsueh clinicaloutcomesofpatientswithresectedoralcavitycancerandsimultaneoussecondprimarymalignancies AT hungmingwang clinicaloutcomesofpatientswithresectedoralcavitycancerandsimultaneoussecondprimarymalignancies AT chitingliau clinicaloutcomesofpatientswithresectedoralcavitycancerandsimultaneoussecondprimarymalignancies AT chenglunghsu clinicaloutcomesofpatientswithresectedoralcavitycancerandsimultaneoussecondprimarymalignancies AT chiahsunhsieh clinicaloutcomesofpatientswithresectedoralcavitycancerandsimultaneoussecondprimarymalignancies AT shuhangng clinicaloutcomesofpatientswithresectedoralcavitycancerandsimultaneoussecondprimarymalignancies AT chihhunglin clinicaloutcomesofpatientswithresectedoralcavitycancerandsimultaneoussecondprimarymalignancies AT chungkantsao clinicaloutcomesofpatientswithresectedoralcavitycancerandsimultaneoussecondprimarymalignancies AT tuanjenfang clinicaloutcomesofpatientswithresectedoralcavitycancerandsimultaneoussecondprimarymalignancies AT shiangfuhuang clinicaloutcomesofpatientswithresectedoralcavitycancerandsimultaneoussecondprimarymalignancies AT kaipingchang clinicaloutcomesofpatientswithresectedoralcavitycancerandsimultaneoussecondprimarymalignancies AT tzuchenyen clinicaloutcomesofpatientswithresectedoralcavitycancerandsimultaneoussecondprimarymalignancies |