Elastographic Evaluation of Thyroid Nodules in Children and Adolescents with Hashimoto’s Thyroiditis and Nodular Goiter with Reference to Cytological and/or Histopathological Diagnosis
There are data indicating the coexistence of papillary thyroid carcinoma and autoimmune thyroiditis (AIT) in children. The aim of the study was elastographic evaluation of thyroid nodules in children and adolescents with AIT and nodular goiter in relation to cytological and/or histopathological diag...
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MDPI AG
2022-10-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/11/21/6339 |
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| author | Hanna Borysewicz-Sańczyk Beata Sawicka Filip Bossowski Janusz Dzięcioł Artur Bossowski |
| author_facet | Hanna Borysewicz-Sańczyk Beata Sawicka Filip Bossowski Janusz Dzięcioł Artur Bossowski |
| author_sort | Hanna Borysewicz-Sańczyk |
| collection | DOAJ |
| description | There are data indicating the coexistence of papillary thyroid carcinoma and autoimmune thyroiditis (AIT) in children. The aim of the study was elastographic evaluation of thyroid nodules in children and adolescents with AIT and nodular goiter in relation to cytological and/or histopathological diagnosis. We examined 215 children (57 boys and 158 girls) with 261 thyroid nodules (143 non-AIT and 118 AIT). All study participants underwent a conventional ultrasound examination with elastography followed by fine needle aspiration biopsy (FNAB). Abnormal Strain Ratio (SR ≥ 5) was observed in 36 non-AIT nodules and 15 AIT nodules. Papillary thyroid carcinoma was diagnosed in 5 patients (2% of all investigated nodules). SR of malignant thyroid nodules was statistically higher in comparison to SR of benign nodules both in the group of non-AIT (6 ± 4 vs. 3.67 ± 2.62, <i>p</i> = 0.024) and AIT nodules (6.3 ± 0.01 vs. 2.92 ± 1.89, <i>p</i> = 0.047). Comparison of non-AIT and AIT benign nodules revealed that SR was higher in non-AIT nodules (3.67 ± 2.62 vs. 2.92 ± 1.89, <i>p</i> = 0.01). We observed a strong positive correlation (R = 1) between TSH concentration and SR ratio in the group of all malignant thyroid nodules. Autoimmune inflammatory process of the thyroid gland does not limit the use of elastography in the diagnosis of thyroid nodules in children. |
| first_indexed | 2024-03-09T18:58:36Z |
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| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-09T18:58:36Z |
| publishDate | 2022-10-01 |
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| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-5f0023c2b12f4e5b8df15066de6c1ba82023-11-24T05:16:02ZengMDPI AGJournal of Clinical Medicine2077-03832022-10-011121633910.3390/jcm11216339Elastographic Evaluation of Thyroid Nodules in Children and Adolescents with Hashimoto’s Thyroiditis and Nodular Goiter with Reference to Cytological and/or Histopathological DiagnosisHanna Borysewicz-Sańczyk0Beata Sawicka1Filip Bossowski2Janusz Dzięcioł3Artur Bossowski4Department of Paediatrics, Endocrinology, Diabetology with Cardiology Unit, Medical University of Bialystok, 15-089 Białystok, PolandDepartment of Paediatrics, Endocrinology, Diabetology with Cardiology Unit, Medical University of Bialystok, 15-089 Białystok, PolandStudent Research Group, Department of Paediatrics, Endocrinology, Diabetology with Cardiology Unit, Medical University of Bialystok, 15-089 Białystok, PolandDepartment of Human Anatomy, Medical University of Bialystok, 15-089 Białystok, PolandDepartment of Paediatrics, Endocrinology, Diabetology with Cardiology Unit, Medical University of Bialystok, 15-089 Białystok, PolandThere are data indicating the coexistence of papillary thyroid carcinoma and autoimmune thyroiditis (AIT) in children. The aim of the study was elastographic evaluation of thyroid nodules in children and adolescents with AIT and nodular goiter in relation to cytological and/or histopathological diagnosis. We examined 215 children (57 boys and 158 girls) with 261 thyroid nodules (143 non-AIT and 118 AIT). All study participants underwent a conventional ultrasound examination with elastography followed by fine needle aspiration biopsy (FNAB). Abnormal Strain Ratio (SR ≥ 5) was observed in 36 non-AIT nodules and 15 AIT nodules. Papillary thyroid carcinoma was diagnosed in 5 patients (2% of all investigated nodules). SR of malignant thyroid nodules was statistically higher in comparison to SR of benign nodules both in the group of non-AIT (6 ± 4 vs. 3.67 ± 2.62, <i>p</i> = 0.024) and AIT nodules (6.3 ± 0.01 vs. 2.92 ± 1.89, <i>p</i> = 0.047). Comparison of non-AIT and AIT benign nodules revealed that SR was higher in non-AIT nodules (3.67 ± 2.62 vs. 2.92 ± 1.89, <i>p</i> = 0.01). We observed a strong positive correlation (R = 1) between TSH concentration and SR ratio in the group of all malignant thyroid nodules. Autoimmune inflammatory process of the thyroid gland does not limit the use of elastography in the diagnosis of thyroid nodules in children.https://www.mdpi.com/2077-0383/11/21/6339childrenthyroid nodulesthyroid cancernodular goiterautoimmune thyroiditisHashimoto’s thyroiditis |
| spellingShingle | Hanna Borysewicz-Sańczyk Beata Sawicka Filip Bossowski Janusz Dzięcioł Artur Bossowski Elastographic Evaluation of Thyroid Nodules in Children and Adolescents with Hashimoto’s Thyroiditis and Nodular Goiter with Reference to Cytological and/or Histopathological Diagnosis Journal of Clinical Medicine children thyroid nodules thyroid cancer nodular goiter autoimmune thyroiditis Hashimoto’s thyroiditis |
| title | Elastographic Evaluation of Thyroid Nodules in Children and Adolescents with Hashimoto’s Thyroiditis and Nodular Goiter with Reference to Cytological and/or Histopathological Diagnosis |
| title_full | Elastographic Evaluation of Thyroid Nodules in Children and Adolescents with Hashimoto’s Thyroiditis and Nodular Goiter with Reference to Cytological and/or Histopathological Diagnosis |
| title_fullStr | Elastographic Evaluation of Thyroid Nodules in Children and Adolescents with Hashimoto’s Thyroiditis and Nodular Goiter with Reference to Cytological and/or Histopathological Diagnosis |
| title_full_unstemmed | Elastographic Evaluation of Thyroid Nodules in Children and Adolescents with Hashimoto’s Thyroiditis and Nodular Goiter with Reference to Cytological and/or Histopathological Diagnosis |
| title_short | Elastographic Evaluation of Thyroid Nodules in Children and Adolescents with Hashimoto’s Thyroiditis and Nodular Goiter with Reference to Cytological and/or Histopathological Diagnosis |
| title_sort | elastographic evaluation of thyroid nodules in children and adolescents with hashimoto s thyroiditis and nodular goiter with reference to cytological and or histopathological diagnosis |
| topic | children thyroid nodules thyroid cancer nodular goiter autoimmune thyroiditis Hashimoto’s thyroiditis |
| url | https://www.mdpi.com/2077-0383/11/21/6339 |
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