Study the polymorphism in UCSNP43, 44 to exon 3 of Calpain-10 gene of Polycystic Ovary Syndrome women in Thi Qar Province
The correlation between polycystic ovary syndrome (PCOS) and type-2 diabetes mellitus (T2DM) was reported regarding T2DM genes, which contribute in the pathogenesis of PCOS. The current study was aimed to investigate the association of CAPN-10 gene UCSNP-43, UCSNP-44 polymorphism with PCOS.Thirty wo...
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| Format: | Article |
| Language: | English |
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University of Thi-Qar
2019-04-01
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| Series: | مجلة علوم ذي قار |
| Subjects: | |
| Online Access: | https://mail.jsci.utq.edu.iq/index.php/main/article/view/9 |
| _version_ | 1827635914152607744 |
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| author | Alia E. Mahmood Enas Abdul Kareem Jabbar Majida G. Magtooph Mohammed Hashim |
| author_facet | Alia E. Mahmood Enas Abdul Kareem Jabbar Majida G. Magtooph Mohammed Hashim |
| author_sort | Alia E. Mahmood |
| collection | DOAJ |
| description | The correlation between polycystic ovary syndrome (PCOS) and type-2 diabetes mellitus (T2DM) was reported regarding T2DM genes, which contribute in the pathogenesis of PCOS. The current study was aimed to investigate the association of CAPN-10 gene UCSNP-43, UCSNP-44 polymorphism with PCOS.Thirty women with PCOS and 20 healthy, which are matched in their age, were selected to test the anthropometric and biochemical profile of our samples. Nucleic acid of samples was extracted and genotype analysis was done. The results of patients-hormonal analysis were indicated that the level of follicle stimulating hormone was low and the levels of other hormones were high in comparison to that of healthy women. Biomass (BMI) and lipid profiles of PCOS patients were higher than from these in healthy women. Haplotypes of sequenced samples were determined for each gene fragment. The same three haplotypes of SNPs-43 were identified in both PCOS and controls samples. On the other hand, high diversity of haplotypes was found from SNPs-44. The meta-analysis with fixed and random effects odds ratio (ORs) on the basis of haplotypes frequencies were presented. |
| first_indexed | 2024-03-09T15:34:01Z |
| format | Article |
| id | doaj.art-5f0241d2d6e14b9ea8497c8cbc066678 |
| institution | Directory Open Access Journal |
| issn | 1991-8690 2709-0256 |
| language | English |
| last_indexed | 2024-03-09T15:34:01Z |
| publishDate | 2019-04-01 |
| publisher | University of Thi-Qar |
| record_format | Article |
| series | مجلة علوم ذي قار |
| spelling | doaj.art-5f0241d2d6e14b9ea8497c8cbc0666782023-11-26T09:41:47ZengUniversity of Thi-Qarمجلة علوم ذي قار1991-86902709-02562019-04-0162Study the polymorphism in UCSNP43, 44 to exon 3 of Calpain-10 gene of Polycystic Ovary Syndrome women in Thi Qar ProvinceAlia E. Mahmood0Enas Abdul Kareem Jabbar 1Majida G. Magtooph2Mohammed Hashim3Biology Department / College Science / Al Mustansiria university Biology Department / College Science / Thi Qar universityBiology Department / College Science / Thi Qar universityBiology Department / College Science / Thi Qar universityThe correlation between polycystic ovary syndrome (PCOS) and type-2 diabetes mellitus (T2DM) was reported regarding T2DM genes, which contribute in the pathogenesis of PCOS. The current study was aimed to investigate the association of CAPN-10 gene UCSNP-43, UCSNP-44 polymorphism with PCOS.Thirty women with PCOS and 20 healthy, which are matched in their age, were selected to test the anthropometric and biochemical profile of our samples. Nucleic acid of samples was extracted and genotype analysis was done. The results of patients-hormonal analysis were indicated that the level of follicle stimulating hormone was low and the levels of other hormones were high in comparison to that of healthy women. Biomass (BMI) and lipid profiles of PCOS patients were higher than from these in healthy women. Haplotypes of sequenced samples were determined for each gene fragment. The same three haplotypes of SNPs-43 were identified in both PCOS and controls samples. On the other hand, high diversity of haplotypes was found from SNPs-44. The meta-analysis with fixed and random effects odds ratio (ORs) on the basis of haplotypes frequencies were presented.https://mail.jsci.utq.edu.iq/index.php/main/article/view/9Polycystic ovarian syndromeGene polymorphismType 2 diabetes mellitushaplotype Calpain-10 |
| spellingShingle | Alia E. Mahmood Enas Abdul Kareem Jabbar Majida G. Magtooph Mohammed Hashim Study the polymorphism in UCSNP43, 44 to exon 3 of Calpain-10 gene of Polycystic Ovary Syndrome women in Thi Qar Province مجلة علوم ذي قار Polycystic ovarian syndrome Gene polymorphism Type 2 diabetes mellitus haplotype Calpain-10 |
| title | Study the polymorphism in UCSNP43, 44 to exon 3 of Calpain-10 gene of Polycystic Ovary Syndrome women in Thi Qar Province |
| title_full | Study the polymorphism in UCSNP43, 44 to exon 3 of Calpain-10 gene of Polycystic Ovary Syndrome women in Thi Qar Province |
| title_fullStr | Study the polymorphism in UCSNP43, 44 to exon 3 of Calpain-10 gene of Polycystic Ovary Syndrome women in Thi Qar Province |
| title_full_unstemmed | Study the polymorphism in UCSNP43, 44 to exon 3 of Calpain-10 gene of Polycystic Ovary Syndrome women in Thi Qar Province |
| title_short | Study the polymorphism in UCSNP43, 44 to exon 3 of Calpain-10 gene of Polycystic Ovary Syndrome women in Thi Qar Province |
| title_sort | study the polymorphism in ucsnp43 44 to exon 3 of calpain 10 gene of polycystic ovary syndrome women in thi qar province |
| topic | Polycystic ovarian syndrome Gene polymorphism Type 2 diabetes mellitus haplotype Calpain-10 |
| url | https://mail.jsci.utq.edu.iq/index.php/main/article/view/9 |
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