Association between Newly Diagnosed Essential Hypertension, Smoking, Assymetric Dimethylarginine and ischemia-Modified Albumin
Objective: This study aimed to investigate the relationship between increasing levels of assymetric dimethylarginine (ADMA)and ischemiamodified albumin (IMA) in people with early diagnosis of hypertension (HT) and smoking history.Methods: The study included 95 outpatients who visited our hospital. P...
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| Format: | Article |
| Language: | English |
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Galenos Yayinevi
2017-06-01
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| Series: | İstanbul Medical Journal |
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http://imj.galenos.com.tr/archives/archive-detail/article-preview/association-between-newly-diagnosed-essential-hype/20464
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| _version_ | 1828021213569482752 |
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| author | Emine Altuntaş Aydın Şükrü Bengü Zeynep Küskü Kiraz Cuma Mertoğlu Levent Dalar Songül Usalp Çavlan Çiftçi |
| author_facet | Emine Altuntaş Aydın Şükrü Bengü Zeynep Küskü Kiraz Cuma Mertoğlu Levent Dalar Songül Usalp Çavlan Çiftçi |
| author_sort | Emine Altuntaş |
| collection | DOAJ |
| description | Objective: This study aimed to investigate the relationship between increasing levels of assymetric dimethylarginine (ADMA)and ischemiamodified albumin (IMA) in people with early diagnosis of hypertension (HT) and smoking history.Methods: The study included 95 outpatients who visited our hospital. Patients were classified into three groups: group 1, healthy and nonsmokers (n=25); group 2, no smoker patients with newly diagnosed essential HT with LVH (left ventricle hypertrophia) (n=35); group 3, smoking patients with a LVH accompanying newly diagnosed essential HT (n=35). 51% of patients are females; 49% of them are males.The trial was approved by the local ethics committee. Blood samples were analyzed, which were taken after 8 h of fasting. Biochemical parameters such as, C reactive protein (CRP), ADMA, IMA values were recorded. Using echocardiography, cardiac values were recorded.Results: In this study, the first group consisted of 25 patients and second and third group of 35 patients. There were 49 females and 46 males; 70 patients were hypertensive and 6 diabetic. Comparing groups 1 and 2, a significant increase in ADMA was found in group 2. A significant difference was available regarding red cell distribution widht(RDW) and neutrophil lymphocyte ratio (N/L) ratio. Both parameters have increased. Significant differences were found between groups 2 and 3 in terms of ADMA, arginine, albumin, and WBC. While ADMA, white blood cell(WBC), and albumin increased and arginine decreases in group 3.Conclusion: There is an association between ADMA level, smoking, and HT. Patients with HT and smoking history showed increased ADMA level compared with normal. Hypertension and smoking are the causes of increased ADMA, but decreased NO level. |
| first_indexed | 2024-04-10T11:49:20Z |
| format | Article |
| id | doaj.art-5f03c3b4934e4ac4b596bb0638cdcb3c |
| institution | Directory Open Access Journal |
| issn | 2619-9793 2148-094X |
| language | English |
| last_indexed | 2024-04-10T11:49:20Z |
| publishDate | 2017-06-01 |
| publisher | Galenos Yayinevi |
| record_format | Article |
| series | İstanbul Medical Journal |
| spelling | doaj.art-5f03c3b4934e4ac4b596bb0638cdcb3c2023-02-15T16:17:13ZengGalenos Yayineviİstanbul Medical Journal2619-97932148-094X2017-06-01182869010.5152/imj.2017.7625813049054Association between Newly Diagnosed Essential Hypertension, Smoking, Assymetric Dimethylarginine and ischemia-Modified AlbuminEmine Altuntaş0Aydın Şükrü Bengü1Zeynep Küskü Kiraz2Cuma Mertoğlu3Levent Dalar4Songül Usalp5Çavlan Çiftçi6 Zonguldak Atatürk Devlet Hastanesi, Kardiyoloji Bölümü, Zonguldak, Türkiye Bingöl Üniversitesi Merkez Laboratuvarı, Bingöl, Türkiye Eskişehir Osmangazi Üniversitesi Tıp Fakültesi, Biyokimya Bilim Dalı, Eskişehir, Türkiye Erzincan Üniversitesi Tıp Fakültesi, Biyokimya Bilim Dalı, Erzincan, Türkiye İstanbul Bilim Üniversitesi Tıp Fakültesi, Göğüs Hastalıkları Anabilim Dalı, İstanbul, Türkiye Tokat Turhal Devlet Hastanesi, Kardiyoloji Bölümü, Tokat, Türkiye İstanbul Bilim Üniversitesi Tıp Fakültesi, Kardiyoloji Anabilim Dalı, İstanbul, Türkiye Objective: This study aimed to investigate the relationship between increasing levels of assymetric dimethylarginine (ADMA)and ischemiamodified albumin (IMA) in people with early diagnosis of hypertension (HT) and smoking history.Methods: The study included 95 outpatients who visited our hospital. Patients were classified into three groups: group 1, healthy and nonsmokers (n=25); group 2, no smoker patients with newly diagnosed essential HT with LVH (left ventricle hypertrophia) (n=35); group 3, smoking patients with a LVH accompanying newly diagnosed essential HT (n=35). 51% of patients are females; 49% of them are males.The trial was approved by the local ethics committee. Blood samples were analyzed, which were taken after 8 h of fasting. Biochemical parameters such as, C reactive protein (CRP), ADMA, IMA values were recorded. Using echocardiography, cardiac values were recorded.Results: In this study, the first group consisted of 25 patients and second and third group of 35 patients. There were 49 females and 46 males; 70 patients were hypertensive and 6 diabetic. Comparing groups 1 and 2, a significant increase in ADMA was found in group 2. A significant difference was available regarding red cell distribution widht(RDW) and neutrophil lymphocyte ratio (N/L) ratio. Both parameters have increased. Significant differences were found between groups 2 and 3 in terms of ADMA, arginine, albumin, and WBC. While ADMA, white blood cell(WBC), and albumin increased and arginine decreases in group 3.Conclusion: There is an association between ADMA level, smoking, and HT. Patients with HT and smoking history showed increased ADMA level compared with normal. Hypertension and smoking are the causes of increased ADMA, but decreased NO level. http://imj.galenos.com.tr/archives/archive-detail/article-preview/association-between-newly-diagnosed-essential-hype/20464 Hypertensionassymetric dimethylargininesmoking |
| spellingShingle | Emine Altuntaş Aydın Şükrü Bengü Zeynep Küskü Kiraz Cuma Mertoğlu Levent Dalar Songül Usalp Çavlan Çiftçi Association between Newly Diagnosed Essential Hypertension, Smoking, Assymetric Dimethylarginine and ischemia-Modified Albumin İstanbul Medical Journal Hypertension assymetric dimethylarginine smoking |
| title | Association between Newly Diagnosed Essential Hypertension, Smoking, Assymetric Dimethylarginine and ischemia-Modified Albumin |
| title_full | Association between Newly Diagnosed Essential Hypertension, Smoking, Assymetric Dimethylarginine and ischemia-Modified Albumin |
| title_fullStr | Association between Newly Diagnosed Essential Hypertension, Smoking, Assymetric Dimethylarginine and ischemia-Modified Albumin |
| title_full_unstemmed | Association between Newly Diagnosed Essential Hypertension, Smoking, Assymetric Dimethylarginine and ischemia-Modified Albumin |
| title_short | Association between Newly Diagnosed Essential Hypertension, Smoking, Assymetric Dimethylarginine and ischemia-Modified Albumin |
| title_sort | association between newly diagnosed essential hypertension smoking assymetric dimethylarginine and ischemia modified albumin |
| topic | Hypertension assymetric dimethylarginine smoking |
| url |
http://imj.galenos.com.tr/archives/archive-detail/article-preview/association-between-newly-diagnosed-essential-hype/20464
|
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