Membrane transporters control cerebrospinal fluid formation independently of conventional osmosis to modulate intracranial pressure

Membrane transporters control cerebrospinal fluid formation independently of conventional osmosis to modulate intracranial pressure

Abstract Background Disturbances in the brain fluid balance can lead to life-threatening elevation in the intracranial pressure (ICP), which represents a vast clinical challenge. Nevertheless, the details underlying the molecular mechanisms governing cerebrospinal fluid (CSF) secretion are largely u...

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Bibliographic Details
Main Authors: Eva K. Oernbo, Annette B. Steffensen, Pooya Razzaghi Khamesi, Trine L. Toft-Bertelsen, Dagne Barbuskaite, Frederik Vilhardt, Niklas J. Gerkau, Katerina Tritsaris, Anja H. Simonsen, Sara D. Lolansen, Søren N. Andreassen, Steen G. Hasselbalch, Thomas Zeuthen, Christine R. Rose, Vartan Kurtcuoglu, Nanna MacAulay
Format: Article
Language:English
Published: BMC 2022-08-01
Series:Fluids and Barriers of the CNS
Subjects:
Cerebrospinal fluid
Choroid plexus
Osmosis
Cotransport
Intracranial pressure
Online Access:https://doi.org/10.1186/s12987-022-00358-4

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