Dynamic Modeling of Cost-effectiveness of Rotavirus Vaccination, Kazakhstan
The government of Kazakhstan, a middle-income country in Central Asia, is considering the introduction of rotavirus vaccination into its national immunization program. We performed a cost-effectiveness analysis of rotavirus vaccination spanning 20 years by using a synthesis of dynamic transmission m...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Centers for Disease Control and Prevention
2014-01-01
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| Series: | Emerging Infectious Diseases |
| Subjects: | |
| Online Access: | https://wwwnc.cdc.gov/eid/article/20/1/13-0019_article |
| _version_ | 1818031119070658560 |
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| author | Birgitte Freiesleben de Blasio Elmira Flem Renat Latipov Ajnagul Kuatbaeva Ivar Sønbø Kristiansen |
| author_facet | Birgitte Freiesleben de Blasio Elmira Flem Renat Latipov Ajnagul Kuatbaeva Ivar Sønbø Kristiansen |
| author_sort | Birgitte Freiesleben de Blasio |
| collection | DOAJ |
| description | The government of Kazakhstan, a middle-income country in Central Asia, is considering the introduction of rotavirus vaccination into its national immunization program. We performed a cost-effectiveness analysis of rotavirus vaccination spanning 20 years by using a synthesis of dynamic transmission models accounting for herd protection. We found that a vaccination program with 90% coverage would prevent ≈880 rotavirus deaths and save an average of 54,784 life-years for children <5 years of age. Indirect protection accounted for 40% and 60% reduction in severe and mild rotavirus gastroenteritis, respectively. Cost per life year gained was US $18,044 from a societal perspective and US $23,892 from a health care perspective. Comparing the 2 key parameters of cost-effectiveness, mortality rates and vaccine cost at <US $2.78 per dose, vaccination program costs would be entirely offset. To further evaluate efficacy of a vaccine program, benefits of indirect protection conferred by vaccination warrant further study. |
| first_indexed | 2024-12-10T05:46:24Z |
| format | Article |
| id | doaj.art-5f05faad9bbe4e6a8b7c78724edba694 |
| institution | Directory Open Access Journal |
| issn | 1080-6040 1080-6059 |
| language | English |
| last_indexed | 2024-12-10T05:46:24Z |
| publishDate | 2014-01-01 |
| publisher | Centers for Disease Control and Prevention |
| record_format | Article |
| series | Emerging Infectious Diseases |
| spelling | doaj.art-5f05faad9bbe4e6a8b7c78724edba6942022-12-22T02:00:09ZengCenters for Disease Control and PreventionEmerging Infectious Diseases1080-60401080-60592014-01-01201293710.3201/eid2001.130019Dynamic Modeling of Cost-effectiveness of Rotavirus Vaccination, KazakhstanBirgitte Freiesleben de BlasioElmira FlemRenat LatipovAjnagul KuatbaevaIvar Sønbø KristiansenThe government of Kazakhstan, a middle-income country in Central Asia, is considering the introduction of rotavirus vaccination into its national immunization program. We performed a cost-effectiveness analysis of rotavirus vaccination spanning 20 years by using a synthesis of dynamic transmission models accounting for herd protection. We found that a vaccination program with 90% coverage would prevent ≈880 rotavirus deaths and save an average of 54,784 life-years for children <5 years of age. Indirect protection accounted for 40% and 60% reduction in severe and mild rotavirus gastroenteritis, respectively. Cost per life year gained was US $18,044 from a societal perspective and US $23,892 from a health care perspective. Comparing the 2 key parameters of cost-effectiveness, mortality rates and vaccine cost at <US $2.78 per dose, vaccination program costs would be entirely offset. To further evaluate efficacy of a vaccine program, benefits of indirect protection conferred by vaccination warrant further study.https://wwwnc.cdc.gov/eid/article/20/1/13-0019_articlevirusesrotavirusvaccinationcost-effectivenessdynamic modelingherd immunity |
| spellingShingle | Birgitte Freiesleben de Blasio Elmira Flem Renat Latipov Ajnagul Kuatbaeva Ivar Sønbø Kristiansen Dynamic Modeling of Cost-effectiveness of Rotavirus Vaccination, Kazakhstan Emerging Infectious Diseases viruses rotavirus vaccination cost-effectiveness dynamic modeling herd immunity |
| title | Dynamic Modeling of Cost-effectiveness of Rotavirus Vaccination, Kazakhstan |
| title_full | Dynamic Modeling of Cost-effectiveness of Rotavirus Vaccination, Kazakhstan |
| title_fullStr | Dynamic Modeling of Cost-effectiveness of Rotavirus Vaccination, Kazakhstan |
| title_full_unstemmed | Dynamic Modeling of Cost-effectiveness of Rotavirus Vaccination, Kazakhstan |
| title_short | Dynamic Modeling of Cost-effectiveness of Rotavirus Vaccination, Kazakhstan |
| title_sort | dynamic modeling of cost effectiveness of rotavirus vaccination kazakhstan |
| topic | viruses rotavirus vaccination cost-effectiveness dynamic modeling herd immunity |
| url | https://wwwnc.cdc.gov/eid/article/20/1/13-0019_article |
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