The prognostic and clinicopathological significance of desmoglein 2 in human cancers: a systematic review and meta-analysis
Objective The survival and clinicopathological significance of desmoglein 2 (DSG2) in various cancers is controversial. Thus, we performed this systematic review and meta-analysis to explore the preliminary prognostic value of DSG2. Methods Eligible studies were identified from databases including P...
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| Format: | Article |
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PeerJ Inc.
2022-03-01
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| Series: | PeerJ |
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| Online Access: | https://peerj.com/articles/13141.pdf |
| _version_ | 1827606783392219136 |
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| author | Jiantao Wang Siyuan Hao Junjie Gu Sean G. Rudd Yan Wang |
| author_facet | Jiantao Wang Siyuan Hao Junjie Gu Sean G. Rudd Yan Wang |
| author_sort | Jiantao Wang |
| collection | DOAJ |
| description | Objective The survival and clinicopathological significance of desmoglein 2 (DSG2) in various cancers is controversial. Thus, we performed this systematic review and meta-analysis to explore the preliminary prognostic value of DSG2. Methods Eligible studies were identified from databases including PubMed, the Cochrane Library, Embase, Web of Science and Scopus. Hand searches were also conducted in relevant bibliographies. We then extracted and pooled hazard ratio (HR) of overall survival (OS) and odds ratio (OR) of clinicopathological features. Results A total of 11 eligible studies containing 1,488 patients were included. Our results demonstrated that in non-small cell lung cancer (NSCLC), high DSG2 expression is associated with poor OS. However, in digestive system cancer and female reproductive system cancer, there were no statistically significant associations between OS and DSG2. Conclusions Based on the findings of this study, high DSG2 expression is associated with worse prognosis in patients with NSCLC, and thus DSG2 expression could be a biomarker for prognosis in NSCLC. |
| first_indexed | 2024-03-09T06:44:17Z |
| format | Article |
| id | doaj.art-5f05ff14158e45748c4273fa07e6ea64 |
| institution | Directory Open Access Journal |
| issn | 2167-8359 |
| language | English |
| last_indexed | 2024-03-09T06:44:17Z |
| publishDate | 2022-03-01 |
| publisher | PeerJ Inc. |
| record_format | Article |
| series | PeerJ |
| spelling | doaj.art-5f05ff14158e45748c4273fa07e6ea642023-12-03T10:41:16ZengPeerJ Inc.PeerJ2167-83592022-03-0110e1314110.7717/peerj.13141The prognostic and clinicopathological significance of desmoglein 2 in human cancers: a systematic review and meta-analysisJiantao Wang0Siyuan Hao1Junjie Gu2Sean G. Rudd3Yan Wang4State Key Laboratory of Biotherapy & Department of Lung Cancer Center and Department of Radiation Oncology, West China Hospital, Sichuan University, Chengdu, ChinaState Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, ChinaState Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, ChinaScience for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, Stockholm, SwedenState Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, ChinaObjective The survival and clinicopathological significance of desmoglein 2 (DSG2) in various cancers is controversial. Thus, we performed this systematic review and meta-analysis to explore the preliminary prognostic value of DSG2. Methods Eligible studies were identified from databases including PubMed, the Cochrane Library, Embase, Web of Science and Scopus. Hand searches were also conducted in relevant bibliographies. We then extracted and pooled hazard ratio (HR) of overall survival (OS) and odds ratio (OR) of clinicopathological features. Results A total of 11 eligible studies containing 1,488 patients were included. Our results demonstrated that in non-small cell lung cancer (NSCLC), high DSG2 expression is associated with poor OS. However, in digestive system cancer and female reproductive system cancer, there were no statistically significant associations between OS and DSG2. Conclusions Based on the findings of this study, high DSG2 expression is associated with worse prognosis in patients with NSCLC, and thus DSG2 expression could be a biomarker for prognosis in NSCLC.https://peerj.com/articles/13141.pdfDesmoglein 2CancerPrognosisSystematic reviewMeta-analysis |
| spellingShingle | Jiantao Wang Siyuan Hao Junjie Gu Sean G. Rudd Yan Wang The prognostic and clinicopathological significance of desmoglein 2 in human cancers: a systematic review and meta-analysis PeerJ Desmoglein 2 Cancer Prognosis Systematic review Meta-analysis |
| title | The prognostic and clinicopathological significance of desmoglein 2 in human cancers: a systematic review and meta-analysis |
| title_full | The prognostic and clinicopathological significance of desmoglein 2 in human cancers: a systematic review and meta-analysis |
| title_fullStr | The prognostic and clinicopathological significance of desmoglein 2 in human cancers: a systematic review and meta-analysis |
| title_full_unstemmed | The prognostic and clinicopathological significance of desmoglein 2 in human cancers: a systematic review and meta-analysis |
| title_short | The prognostic and clinicopathological significance of desmoglein 2 in human cancers: a systematic review and meta-analysis |
| title_sort | prognostic and clinicopathological significance of desmoglein 2 in human cancers a systematic review and meta analysis |
| topic | Desmoglein 2 Cancer Prognosis Systematic review Meta-analysis |
| url | https://peerj.com/articles/13141.pdf |
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