Saikosaponin D Inhibited IL-1β Induced ATDC 5 Chondrocytes Apoptosis In Vitro and Delayed Articular Cartilage Degeneration in OA Model Mice In Vivo

Saikosaponin D Inhibited IL-1β Induced ATDC 5 Chondrocytes Apoptosis In Vitro and Delayed Articular Cartilage Degeneration in OA Model Mice In Vivo

Osteoarthritis (OA) is the most common joint disease in the elderly, characterized by cartilage degradation and proliferation of subchondral bone. The pathogenesis of OA involves a variety of inflammatory mediators, including nitric oxide (NO), prostaglandin E2 (PGE2), tumor necrosis factor (TNF)-α,...

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Bibliographic Details
Main Authors: Xinhui Wu, Kangxian Zhao, Xiaoxin Fang, Feng Lu, Pu Cheng, Xiaoting Song, Weikang Zhang, Can Yao, Jiling Zhu, Haixiao Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-03-01
Series:Frontiers in Pharmacology
Subjects:
Saikosaponin D
osteoarthritis
Nrf2
HO-1
ROS
NF-κB
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.845959/full

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