Measuring Drug Therapy Effect on Osteoporotic Fracture Risk by Trabecular Bone Lacunarity: The LOTO Study
An MRI method providing one parameter (TBLβ: trabecular-bone-lacunarity-parameter-β) that is sensitive to trabecular bone architecture (TBA) changes with aging and osteoporosis is under study as a new tool in the early diagnosis of bone fragility fracture. A cross-sectional and prospective observati...
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MDPI AG
2023-03-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/11/3/781 |
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| author | Annamaria Zaia Pierluigi Maponi Manuela Sallei Roberta Galeazzi Pietro Scendoni |
| author_facet | Annamaria Zaia Pierluigi Maponi Manuela Sallei Roberta Galeazzi Pietro Scendoni |
| author_sort | Annamaria Zaia |
| collection | DOAJ |
| description | An MRI method providing one parameter (TBLβ: trabecular-bone-lacunarity-parameter-β) that is sensitive to trabecular bone architecture (TBA) changes with aging and osteoporosis is under study as a new tool in the early diagnosis of bone fragility fracture. A cross-sectional and prospective observational study (LOTO: Lacunarity Of Trabecular bone in Osteoporosis) on over-50s women, at risk for bone fragility fracture, was designed to validate the method. From the baseline data, we observed that in women with prevalent vertebral fractures (VF+), TBA was differently characterized by TBLβ when osteoporosis treatment is considered. Here we verify the potential of TBLβ as an index of osteoporosis treatment efficacy. Untreated (<i>N</i> = 156) and treated (<i>N</i> = 123) women were considered to assess differences in TBLβ related to osteoporosis treatment. Prevalent VFs were found in 31% of subjects, 63% of which were under osteoporosis medications. The results show that TBLβ discriminates between VF+ and VF− patients (<i>p</i> = 0.004). This result is mostly stressed in untreated subjects. Treatment, drug therapy in particular (89% Bisphosphonates), significantly counteracts the difference between VF+ and VF− within and between groups: TBLβ values in treated patients are comparable to untreated VF− and statistically higher than untreated VF+ (<i>p</i> = 0.014) ones. These results highlight the potential role of TBLβ as an index of treatment efficacy. |
| first_indexed | 2024-03-11T06:53:31Z |
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| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-11T06:53:31Z |
| publishDate | 2023-03-01 |
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| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-5f07160617e741faa7bce17bf1a589e22023-11-17T09:45:31ZengMDPI AGBiomedicines2227-90592023-03-0111378110.3390/biomedicines11030781Measuring Drug Therapy Effect on Osteoporotic Fracture Risk by Trabecular Bone Lacunarity: The LOTO StudyAnnamaria Zaia0Pierluigi Maponi1Manuela Sallei2Roberta Galeazzi3Pietro Scendoni4Centre of Innovative Models and Technology for Ageing Care, Scientific Direction, IRCCS INRCA, 60121 Ancona, ItalySchool of Science and Technology, University of Camerino, 62032 Camerino, ItalyMedical Imaging Division, Geriatric Hospital, IRCCS INRCA, 60121 Ancona, ItalyAnalysis Laboratory, Geriatric Hospital, IRCCS INRCA, 60121 Ancona, ItalyRheumatology Division, Geriatric Hospital, IRCCS INRCA, 63900 Fermo, ItalyAn MRI method providing one parameter (TBLβ: trabecular-bone-lacunarity-parameter-β) that is sensitive to trabecular bone architecture (TBA) changes with aging and osteoporosis is under study as a new tool in the early diagnosis of bone fragility fracture. A cross-sectional and prospective observational study (LOTO: Lacunarity Of Trabecular bone in Osteoporosis) on over-50s women, at risk for bone fragility fracture, was designed to validate the method. From the baseline data, we observed that in women with prevalent vertebral fractures (VF+), TBA was differently characterized by TBLβ when osteoporosis treatment is considered. Here we verify the potential of TBLβ as an index of osteoporosis treatment efficacy. Untreated (<i>N</i> = 156) and treated (<i>N</i> = 123) women were considered to assess differences in TBLβ related to osteoporosis treatment. Prevalent VFs were found in 31% of subjects, 63% of which were under osteoporosis medications. The results show that TBLβ discriminates between VF+ and VF− patients (<i>p</i> = 0.004). This result is mostly stressed in untreated subjects. Treatment, drug therapy in particular (89% Bisphosphonates), significantly counteracts the difference between VF+ and VF− within and between groups: TBLβ values in treated patients are comparable to untreated VF− and statistically higher than untreated VF+ (<i>p</i> = 0.014) ones. These results highlight the potential role of TBLβ as an index of treatment efficacy.https://www.mdpi.com/2227-9059/11/3/781osteoporosisfracture riskosteoporosis treatmentvitamin Ddrug therapybisphosphonates |
| spellingShingle | Annamaria Zaia Pierluigi Maponi Manuela Sallei Roberta Galeazzi Pietro Scendoni Measuring Drug Therapy Effect on Osteoporotic Fracture Risk by Trabecular Bone Lacunarity: The LOTO Study Biomedicines osteoporosis fracture risk osteoporosis treatment vitamin D drug therapy bisphosphonates |
| title | Measuring Drug Therapy Effect on Osteoporotic Fracture Risk by Trabecular Bone Lacunarity: The LOTO Study |
| title_full | Measuring Drug Therapy Effect on Osteoporotic Fracture Risk by Trabecular Bone Lacunarity: The LOTO Study |
| title_fullStr | Measuring Drug Therapy Effect on Osteoporotic Fracture Risk by Trabecular Bone Lacunarity: The LOTO Study |
| title_full_unstemmed | Measuring Drug Therapy Effect on Osteoporotic Fracture Risk by Trabecular Bone Lacunarity: The LOTO Study |
| title_short | Measuring Drug Therapy Effect on Osteoporotic Fracture Risk by Trabecular Bone Lacunarity: The LOTO Study |
| title_sort | measuring drug therapy effect on osteoporotic fracture risk by trabecular bone lacunarity the loto study |
| topic | osteoporosis fracture risk osteoporosis treatment vitamin D drug therapy bisphosphonates |
| url | https://www.mdpi.com/2227-9059/11/3/781 |
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