A New Hybrid Molecule Based on (5<i>Z</i>,9<i>Z</i>)-icosa-5,9-dienoic Acid and Monocarbonyl Derivatives of Curcuminoids

A New Hybrid Molecule Based on (5<i>Z</i>,9<i>Z</i>)-icosa-5,9-dienoic Acid and Monocarbonyl Derivatives of Curcuminoids

Efficient methods for the synthesis of previously undescribed hybrid compounds based on monocarbonyl derivatives of curcumin and 5<i>Z</i>,9<i>Z</i>-dienoic acid with yields of 58–66% are presented. The key monomer, (5<i>Z</i>,9<i>Z</i>)-icosa-5,9-dien...

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Bibliographic Details
Main Authors: Ilgiz Islamov, Adelya Yusupova, Snezhana Sharafutdinova, Usein Dzhemilev
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:Chemistry Proceedings
Subjects:
1,5-dienoic compounds
cross-cyclomagnesiation
Grignard reagents
fatty acids
curcuminoids
Online Access:https://www.mdpi.com/2673-4583/12/1/45
Description
Summary:Efficient methods for the synthesis of previously undescribed hybrid compounds based on monocarbonyl derivatives of curcumin and 5<i>Z</i>,9<i>Z</i>-dienoic acid with yields of 58–66% are presented. The key monomer, (5<i>Z</i>,9<i>Z</i>)-icosa-5,9-dienoic acid, was prepared using the stereoselective cross-cyclomagnesiation reaction of aliphatic and oxygen-containing 1,2-dienes catalyzed by Cp<sub>2</sub>TiCl<sub>2</sub>.
ISSN:2673-4583

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