Detecting apathy in patients with cerebral small vessel disease
BackgroundApathy is attracting more and more attention in clinical practice. As one of the most common features of cerebral small vessel disease (CSVD), the assessment of apathy still mainly relies on observers. With the development of Information and Communication Technologies (ICTs), new objective...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-08-01
|
| Series: | Frontiers in Aging Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fnagi.2022.933958/full |
| _version_ | 1811220145871257600 |
|---|---|
| author | Xiaoping Cai Xiaoping Cai Hóngyi Zhào Hóngyi Zhào Zhiyi Li Yu Ding Yonghua Huang |
| author_facet | Xiaoping Cai Xiaoping Cai Hóngyi Zhào Hóngyi Zhào Zhiyi Li Yu Ding Yonghua Huang |
| author_sort | Xiaoping Cai |
| collection | DOAJ |
| description | BackgroundApathy is attracting more and more attention in clinical practice. As one of the most common features of cerebral small vessel disease (CSVD), the assessment of apathy still mainly relies on observers. With the development of Information and Communication Technologies (ICTs), new objective tools take part in the early detection of apathy.ObjectivesTo detect apathy in patients with CSVD and find out the relationship between apathy and actigraphic data sampled from the diurnal and nocturnal periods.MethodsA total of 56 patients with CSVD were recruited for a cross-sectional observational study. Apathy was diagnosed by the diagnostic criteria for apathy in neurocognitive disorders. The presence of lacunes, white matter hyperintensities, cerebral microbleeds (CMBs), and perivascular spaces (PVS) in magnetic resonance imaging (MRI) images were rated independently. Actigraph devices were worn in the non-dominant hands of each subject for 7 consecutive days to collect samples of raw data, and diurnal vector magnitude (VM) and a series of sleep quality variables were obtained.ResultsWe found that the frequency of apathy in Chinese patients with CSVD reached 37.50%. Patients in the Apathy+ group showed more lacunes and CMBs, and higher Fazekas scores in comparison to apathy-group individuals. Diurnal VM, instead of other sleep quality variables, was lower in CSVD patients with apathy relative to those without apathy. Lastly, we discovered that diurnal VM and total time in bed (TTB) correlated negatively with apathy severity in patients with CSVD.ConclusionActigraphy is a promising choice to evaluate apathy in patients with CSVD. |
| first_indexed | 2024-04-12T07:36:39Z |
| format | Article |
| id | doaj.art-5f09381c3f7b414b966716454cd66eed |
| institution | Directory Open Access Journal |
| issn | 1663-4365 |
| language | English |
| last_indexed | 2024-04-12T07:36:39Z |
| publishDate | 2022-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging Neuroscience |
| spelling | doaj.art-5f09381c3f7b414b966716454cd66eed2022-12-22T03:41:55ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652022-08-011410.3389/fnagi.2022.933958933958Detecting apathy in patients with cerebral small vessel diseaseXiaoping Cai0Xiaoping Cai1Hóngyi Zhào2Hóngyi Zhào3Zhiyi Li4Yu Ding5Yonghua Huang6Department of Neurology, The Seventh Medical Center of Chinese PLA General Hospital, Beijing, China7th Department of Health Cadre, The Second Medical Center of Chinese PLA General Hospital, Beijing, ChinaDepartment of Neurology, The Seventh Medical Center of Chinese PLA General Hospital, Beijing, ChinaDepartment of Neurology, NO 984 Hospital of PLA, Beijing, ChinaDepartment of Neurology, NO 984 Hospital of PLA, Beijing, ChinaDepartment of Neurology, The Seventh Medical Center of Chinese PLA General Hospital, Beijing, ChinaDepartment of Neurology, The Seventh Medical Center of Chinese PLA General Hospital, Beijing, ChinaBackgroundApathy is attracting more and more attention in clinical practice. As one of the most common features of cerebral small vessel disease (CSVD), the assessment of apathy still mainly relies on observers. With the development of Information and Communication Technologies (ICTs), new objective tools take part in the early detection of apathy.ObjectivesTo detect apathy in patients with CSVD and find out the relationship between apathy and actigraphic data sampled from the diurnal and nocturnal periods.MethodsA total of 56 patients with CSVD were recruited for a cross-sectional observational study. Apathy was diagnosed by the diagnostic criteria for apathy in neurocognitive disorders. The presence of lacunes, white matter hyperintensities, cerebral microbleeds (CMBs), and perivascular spaces (PVS) in magnetic resonance imaging (MRI) images were rated independently. Actigraph devices were worn in the non-dominant hands of each subject for 7 consecutive days to collect samples of raw data, and diurnal vector magnitude (VM) and a series of sleep quality variables were obtained.ResultsWe found that the frequency of apathy in Chinese patients with CSVD reached 37.50%. Patients in the Apathy+ group showed more lacunes and CMBs, and higher Fazekas scores in comparison to apathy-group individuals. Diurnal VM, instead of other sleep quality variables, was lower in CSVD patients with apathy relative to those without apathy. Lastly, we discovered that diurnal VM and total time in bed (TTB) correlated negatively with apathy severity in patients with CSVD.ConclusionActigraphy is a promising choice to evaluate apathy in patients with CSVD.https://www.frontiersin.org/articles/10.3389/fnagi.2022.933958/fullactigraphyapathysmall vessel diseasesleepneuropsychiatric disorders |
| spellingShingle | Xiaoping Cai Xiaoping Cai Hóngyi Zhào Hóngyi Zhào Zhiyi Li Yu Ding Yonghua Huang Detecting apathy in patients with cerebral small vessel disease Frontiers in Aging Neuroscience actigraphy apathy small vessel disease sleep neuropsychiatric disorders |
| title | Detecting apathy in patients with cerebral small vessel disease |
| title_full | Detecting apathy in patients with cerebral small vessel disease |
| title_fullStr | Detecting apathy in patients with cerebral small vessel disease |
| title_full_unstemmed | Detecting apathy in patients with cerebral small vessel disease |
| title_short | Detecting apathy in patients with cerebral small vessel disease |
| title_sort | detecting apathy in patients with cerebral small vessel disease |
| topic | actigraphy apathy small vessel disease sleep neuropsychiatric disorders |
| url | https://www.frontiersin.org/articles/10.3389/fnagi.2022.933958/full |
| work_keys_str_mv | AT xiaopingcai detectingapathyinpatientswithcerebralsmallvesseldisease AT xiaopingcai detectingapathyinpatientswithcerebralsmallvesseldisease AT hongyizhao detectingapathyinpatientswithcerebralsmallvesseldisease AT hongyizhao detectingapathyinpatientswithcerebralsmallvesseldisease AT zhiyili detectingapathyinpatientswithcerebralsmallvesseldisease AT yuding detectingapathyinpatientswithcerebralsmallvesseldisease AT yonghuahuang detectingapathyinpatientswithcerebralsmallvesseldisease |