Multiple cutaneous melanomas associated with gastric and brain metastases
Abstract The occurrence of multiple primary melanomas in a single individual is rare. Most commonly, malignant melanocytic lesions subsequent to the initial diagnosis of melanoma are secondary cutaneous metastases. We report a patient with gastrointestinal bleeding from gastric metastasis of cutaneo...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Sociedade Brasileira de Dermatologia
2016-10-01
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| Series: | Anais Brasileiros de Dermatologia |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962016001100098&tlng=en |
| _version_ | 1819258980590944256 |
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| author | Lara Caroline Grander Fernanda Cabral Alice Paixão Lisboa Gabrielle Vale Carlos Baptista Barcaui Juan Manuel Pineiro Maceira |
| author_facet | Lara Caroline Grander Fernanda Cabral Alice Paixão Lisboa Gabrielle Vale Carlos Baptista Barcaui Juan Manuel Pineiro Maceira |
| author_sort | Lara Caroline Grander |
| collection | DOAJ |
| description | Abstract The occurrence of multiple primary melanomas in a single individual is rare. Most commonly, malignant melanocytic lesions subsequent to the initial diagnosis of melanoma are secondary cutaneous metastases. We report a patient with gastrointestinal bleeding from gastric metastasis of cutaneous melanoma. During clinical evaluation and staging, we discovered a brain metastasis associated with 3 synchronous primary cutaneous melanomas. We suggest the research on the mutation in the cyclin-dependent kinase inhibitor 2A (CDKN2A) (INK4a) in such cases. We also emphasize the importance of clinical examination and dermoscopy of the entire tegument, even after a malignant melanocytic lesion is identified. |
| first_indexed | 2024-12-23T19:02:44Z |
| format | Article |
| id | doaj.art-5f0a38f848544a00b947f0e9d0bd84e6 |
| institution | Directory Open Access Journal |
| issn | 0365-0596 |
| language | English |
| last_indexed | 2024-12-23T19:02:44Z |
| publishDate | 2016-10-01 |
| publisher | Sociedade Brasileira de Dermatologia |
| record_format | Article |
| series | Anais Brasileiros de Dermatologia |
| spelling | doaj.art-5f0a38f848544a00b947f0e9d0bd84e62022-12-21T17:34:41ZengSociedade Brasileira de DermatologiaAnais Brasileiros de Dermatologia0365-05962016-10-01915 suppl 19810010.1590/abd1806-4841.20164374Multiple cutaneous melanomas associated with gastric and brain metastasesLara Caroline GranderFernanda CabralAlice Paixão LisboaGabrielle ValeCarlos Baptista BarcauiJuan Manuel Pineiro MaceiraAbstract The occurrence of multiple primary melanomas in a single individual is rare. Most commonly, malignant melanocytic lesions subsequent to the initial diagnosis of melanoma are secondary cutaneous metastases. We report a patient with gastrointestinal bleeding from gastric metastasis of cutaneous melanoma. During clinical evaluation and staging, we discovered a brain metastasis associated with 3 synchronous primary cutaneous melanomas. We suggest the research on the mutation in the cyclin-dependent kinase inhibitor 2A (CDKN2A) (INK4a) in such cases. We also emphasize the importance of clinical examination and dermoscopy of the entire tegument, even after a malignant melanocytic lesion is identified.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962016001100098&tlng=enCyclin-dependent kinase inhibitor proteinCyclin-dependent KinasesMelanomaNeoplasm metastasis |
| spellingShingle | Lara Caroline Grander Fernanda Cabral Alice Paixão Lisboa Gabrielle Vale Carlos Baptista Barcaui Juan Manuel Pineiro Maceira Multiple cutaneous melanomas associated with gastric and brain metastases Anais Brasileiros de Dermatologia Cyclin-dependent kinase inhibitor protein Cyclin-dependent Kinases Melanoma Neoplasm metastasis |
| title | Multiple cutaneous melanomas associated with gastric and brain metastases |
| title_full | Multiple cutaneous melanomas associated with gastric and brain metastases |
| title_fullStr | Multiple cutaneous melanomas associated with gastric and brain metastases |
| title_full_unstemmed | Multiple cutaneous melanomas associated with gastric and brain metastases |
| title_short | Multiple cutaneous melanomas associated with gastric and brain metastases |
| title_sort | multiple cutaneous melanomas associated with gastric and brain metastases |
| topic | Cyclin-dependent kinase inhibitor protein Cyclin-dependent Kinases Melanoma Neoplasm metastasis |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962016001100098&tlng=en |
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