Anti-allodynic Effect of Mangiferin in Rats With Chronic Post-ischemia Pain: A Model of Complex Regional Pain Syndrome Type I
The present study reproduces chronic post-ischemia pain (CPIP), a model of complex regional pain syndrome type I (CRPS-I), in rats to examine the possible transient and long-term anti-allodynic effect of mangiferin (MG); as well as its potential beneficial interactions with some standard analgesic d...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2018-10-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fphar.2018.01119/full |
| _version_ | 1819084050497798144 |
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| author | Bárbara B. Garrido-Suárez Gabino Garrido Marian Castro-Labrada Zenia Pardo-Ruíz Addis Bellma Menéndez Evelyn Spencer Jozi Godoy-Figueiredo Sergio H. Ferreira René Delgado-Hernández |
| author_facet | Bárbara B. Garrido-Suárez Gabino Garrido Marian Castro-Labrada Zenia Pardo-Ruíz Addis Bellma Menéndez Evelyn Spencer Jozi Godoy-Figueiredo Sergio H. Ferreira René Delgado-Hernández |
| author_sort | Bárbara B. Garrido-Suárez |
| collection | DOAJ |
| description | The present study reproduces chronic post-ischemia pain (CPIP), a model of complex regional pain syndrome type I (CRPS-I), in rats to examine the possible transient and long-term anti-allodynic effect of mangiferin (MG); as well as its potential beneficial interactions with some standard analgesic drugs and sympathetic-mediated vasoconstriction and vasodilator agents during the earlier stage of the pathology. A single dose of MG (50 and 100 mg/kg, p.o.) decreased mechanical allodynia 72 h post-ischemia-reperfusion (I/R). MG 100 mg/kg, i.p. (pre- vs. post-drug) increased von Frey thresholds in a yohimbine and naloxone-sensitive manner. Sub-effective doses of morphine, amitriptyline, prazosin, clonidine and a NO donor, SIN-1, in the presence of MG were found to be significantly anti-allodynic. A long-term anti-allodynic effect at 7 and 13 days post-I/R after repeated oral doses of MG (50 and 100 mg/kg) was also observed. Further, MG decreased spinal and muscle interleukin-1β concentration and restored muscle redox status. These results indicate that MG has a transient and long-term anti-allodynic effect in CPIP rats that appears to be at least partially attributable to the opioid and α2 adrenergic receptors. Additionally, its anti-inflammatory and antioxidant mechanisms could also be implicated in this effect. The association of MG with sub-effective doses of these drugs enhances the anti-allodynic effect; however, an isobolographic analysis should be performed to define a functional interaction between them. These findings suggest the possible clinical use of MG in the treatment of CRPS-I in both early sympathetically maintained pain and long-term sympathetically independent pain. |
| first_indexed | 2024-12-21T20:42:18Z |
| format | Article |
| id | doaj.art-5f0ac9a69dd344229970a71fcab4c996 |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-12-21T20:42:18Z |
| publishDate | 2018-10-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Pharmacology |
| spelling | doaj.art-5f0ac9a69dd344229970a71fcab4c9962022-12-21T18:50:55ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122018-10-01910.3389/fphar.2018.01119406930Anti-allodynic Effect of Mangiferin in Rats With Chronic Post-ischemia Pain: A Model of Complex Regional Pain Syndrome Type IBárbara B. Garrido-Suárez0Gabino Garrido1Marian Castro-Labrada2Zenia Pardo-Ruíz3Addis Bellma Menéndez4Evelyn Spencer5Jozi Godoy-Figueiredo6Sergio H. Ferreira7René Delgado-Hernández8Laboratorio de Farmacología y Toxicología, Centro de Investigación y Desarrollo de Medicamentos, Havana, CubaDepartamento de Ciencias Farmacéuticas, Facultad de Ciencias, Universidad Católica del Norte, Antofagasta, ChileLaboratorio de Farmacología y Toxicología, Centro de Investigación y Desarrollo de Medicamentos, Havana, CubaLaboratorio de Farmacología y Toxicología, Centro de Investigación y Desarrollo de Medicamentos, Havana, CubaLaboratorio de Farmacología y Toxicología, Centro de Investigación y Desarrollo de Medicamentos, Havana, CubaLaboratorio de Farmacología y Toxicología, Centro de Investigación y Desarrollo de Medicamentos, Havana, CubaDepartment of Pharmacology, Faculty of Medicine of Ribeirão Preto, University of São Paulo, São Paulo, BrazilDepartment of Pharmacology, Faculty of Medicine of Ribeirão Preto, University of São Paulo, São Paulo, BrazilCentro de Estudio para las Investigaciones y Evaluaciones Biológicas, Instituto de Farmacia y Alimentos, Universidad de La Habana, Havana, CubaThe present study reproduces chronic post-ischemia pain (CPIP), a model of complex regional pain syndrome type I (CRPS-I), in rats to examine the possible transient and long-term anti-allodynic effect of mangiferin (MG); as well as its potential beneficial interactions with some standard analgesic drugs and sympathetic-mediated vasoconstriction and vasodilator agents during the earlier stage of the pathology. A single dose of MG (50 and 100 mg/kg, p.o.) decreased mechanical allodynia 72 h post-ischemia-reperfusion (I/R). MG 100 mg/kg, i.p. (pre- vs. post-drug) increased von Frey thresholds in a yohimbine and naloxone-sensitive manner. Sub-effective doses of morphine, amitriptyline, prazosin, clonidine and a NO donor, SIN-1, in the presence of MG were found to be significantly anti-allodynic. A long-term anti-allodynic effect at 7 and 13 days post-I/R after repeated oral doses of MG (50 and 100 mg/kg) was also observed. Further, MG decreased spinal and muscle interleukin-1β concentration and restored muscle redox status. These results indicate that MG has a transient and long-term anti-allodynic effect in CPIP rats that appears to be at least partially attributable to the opioid and α2 adrenergic receptors. Additionally, its anti-inflammatory and antioxidant mechanisms could also be implicated in this effect. The association of MG with sub-effective doses of these drugs enhances the anti-allodynic effect; however, an isobolographic analysis should be performed to define a functional interaction between them. These findings suggest the possible clinical use of MG in the treatment of CRPS-I in both early sympathetically maintained pain and long-term sympathetically independent pain.https://www.frontiersin.org/article/10.3389/fphar.2018.01119/fulladrenergic receptorchronic post-ischemia paincomplex regional pain syndromemangiferinsympathetically maintained pain |
| spellingShingle | Bárbara B. Garrido-Suárez Gabino Garrido Marian Castro-Labrada Zenia Pardo-Ruíz Addis Bellma Menéndez Evelyn Spencer Jozi Godoy-Figueiredo Sergio H. Ferreira René Delgado-Hernández Anti-allodynic Effect of Mangiferin in Rats With Chronic Post-ischemia Pain: A Model of Complex Regional Pain Syndrome Type I Frontiers in Pharmacology adrenergic receptor chronic post-ischemia pain complex regional pain syndrome mangiferin sympathetically maintained pain |
| title | Anti-allodynic Effect of Mangiferin in Rats With Chronic Post-ischemia Pain: A Model of Complex Regional Pain Syndrome Type I |
| title_full | Anti-allodynic Effect of Mangiferin in Rats With Chronic Post-ischemia Pain: A Model of Complex Regional Pain Syndrome Type I |
| title_fullStr | Anti-allodynic Effect of Mangiferin in Rats With Chronic Post-ischemia Pain: A Model of Complex Regional Pain Syndrome Type I |
| title_full_unstemmed | Anti-allodynic Effect of Mangiferin in Rats With Chronic Post-ischemia Pain: A Model of Complex Regional Pain Syndrome Type I |
| title_short | Anti-allodynic Effect of Mangiferin in Rats With Chronic Post-ischemia Pain: A Model of Complex Regional Pain Syndrome Type I |
| title_sort | anti allodynic effect of mangiferin in rats with chronic post ischemia pain a model of complex regional pain syndrome type i |
| topic | adrenergic receptor chronic post-ischemia pain complex regional pain syndrome mangiferin sympathetically maintained pain |
| url | https://www.frontiersin.org/article/10.3389/fphar.2018.01119/full |
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