Neuronal toll like receptor 9 contributes to complete Freund’s adjuvant-induced inflammatory pain in mice

Neuronal toll like receptor 9 contributes to complete Freund’s adjuvant-induced inflammatory pain in mice

Toll like receptor 9 (TLR9) is a critical sensor for danger-associated molecular patterns (DAMPs) and a crucial marker of non-sterile/sterile inflammation among all TLRs. However, the significance of TLR9 in inflammatory pain remains unclear. Here, we subcutaneously injected Complete Freund’s adjuva...

Full description

Bibliographic Details
Main Authors:	Yu Chen, Hui Chen, Xiao-Chen Li, Wen-Li Mi, Yu-Xia Chu, Yan-Qing Wang, Qi-Liang Mao-Ying
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-10-01
Series:	Frontiers in Molecular Neuroscience
Subjects:	inflammatory pain toll-like receptor 9 toll-like receptor 9 antagonist CpG ODN spinal cord neuron
Online Access:	https://www.frontiersin.org/articles/10.3389/fnmol.2022.1008203/full

Similar Items

The effect of CpG-ODN (Toll-like receptor 21 agonist) as an adjuvant for Newcastle disease vaccination in broiler chicken
by: Ghada K. Gamal, et al.
Published: (2021-07-01)

Control of A/D type CpG-ODN aggregates to a suitable size for induction of strong immunostimulant activity
by: Miyu Matsuda, et al.
Published: (2023-12-01)

Cytidine-phosphate-guanosine oligodeoxynucleotides in combination with CD40 ligand decrease periodontal inflammation and alveolar bone loss in a TLR9-independent manner
by: Qian Zhao, et al.
Published: (2018-05-01)

Immunostimulatory Activities of CpG-Oligodeoxynucleotides in Teleosts: Toll-Like Receptors 9 and 21
by: Chao-Yang Lai, et al.
Published: (2019-02-01)

CpG Oligodeoxynucleotides for Anticancer Monotherapy from Preclinical Stages to Clinical Trials
by: Zhongkun Zhang, et al.
Published: (2021-12-01)

Research progress on the mechanism of Toll-like receptor 9 in respiratory diseases
by: Yan Jiangxue, Cao Nannan, Ding Xia, Ni Qian
Published: (2022-04-01)

A Role of Intracellular Toll-Like Receptors (3, 7, and 9) in Response to <i>Mycobacterium tuberculosis</i> and Co-Infection with HIV
by: Huy Nguyen, et al.
Published: (2020-08-01)

TLR9/NF-kB Pathway Regulates Brucella CpG DNA-mediated Cytokine Response in Human Peripheral Blood Mononuclear Cells
by: Yunzhi Peng, et al.
Published: (2021-12-01)

TLR9 Monotherapy in Immune-Competent Mice Suppresses Orthotopic Prostate Tumor Development
by: Mark A. Miles, et al.
Published: (2024-01-01)

CpG oligodeoxynucleotide nanomedicines for the prophylaxis or treatment of cancers, infectious diseases, and allergies
by: Hanagata N
Published: (2017-01-01)

Toll-Like Receptors
by: Aycan Kundakcı, et al.
Published: (2012-08-01)

Toll 7 and Toll 9 in psoriasis vulgaris before and after phototherapy
by: Doaa Mahgoub, et al.
Published: (2014-04-01)

Toll‐like receptor 9 signaling in chronic lymphocytic leukemia cell lines
by: Miriam Meloni, et al.
Published: (2023-12-01)

Cleavage of Toll-Like Receptor 9 Ectodomain Is Required for In Vivo Responses to Single Strand DNA
by: Ryutaro Fukui, et al.
Published: (2018-06-01)

Toll-Like Receptor (TLR)-9 rs352140 Polymorphism is an Immunopathology Protective Factor in Parkinson's Disease in the Northern Iranian Population
by: Niloufar Sadat Miri, et al.
Published: (2020-12-01)

Macrophages Impair TLR9 Agonist Antitumor Activity through Interacting with the Anti-PD-1 Antibody Fc Domain
by: Simone Camelliti, et al.
Published: (2021-08-01)

Ovine Toll-like Receptor 9 (<i>TLR9</i>) Gene Variation and Its Association with Flystrike Susceptibility
by: Xiu Liu, et al.
Published: (2021-12-01)

Polymorphism in Toll-Like Receptors and <i>Helicobacter Pylori</i> Motility in Autoimmune Atrophic Gastritis and Gastric Cancer
by: Valli De Re, et al.
Published: (2019-05-01)

The Expression of Plasmacytoid Dendritic Cells and TLR7/9-MyD88-IRAKs Pathway in Chronic Eczema Lesions
by: Wen J, et al.
Published: (2023-04-01)

Prediction of novel mouse TLR9 agonists using a random forest approach
by: Varun Khanna, et al.
Published: (2019-12-01)

Chronic exposure to indoxacarb and pulmonary expression of toll-like receptor-9 in mice
by: Sandeep Kaur, et al.
Published: (2016-11-01)

TLR9 acts as a sensor for tumor-released DNA to modulate anti-tumor immunity after chemotherapy
by: Tae Heung Kang, et al.
Published: (2019-10-01)

Tick-Virus Interactions: Toll Sensing
by: Nicholas Johnson, et al.
Published: (2017-06-01)

Mannose Receptor Ligands Regulate the Gene Expression of Toll-like Receptors in Chicken Monocytes
by: Li Yan, et al.
Published: (2013-10-01)

Changes and significance of TLR7/9 and IFN-Ⅰ levels in children with severe mycoplasma pneumoniae pneumonia
by: Yan Jiangxue, Ding Xia, Jiao Qiongjie, Huang Li, Cao Nannan, Dong Xinfang, Ni Qian
Published: (2023-03-01)

Human and Bacterial Toll-Interleukin Receptor Domains Exhibit Distinct Dynamic Features and Functions
by: Eunjeong Lee, et al.
Published: (2022-07-01)

Toll-like Receptor Ligands Enhance Vaccine Efficacy against a Virulent Newcastle Disease Virus Challenge in Chickens
by: Chang-Won Lee, et al.
Published: (2023-10-01)

Helicobacter pylori DNA promotes cellular proliferation, migration, and invasion of gastric cancer by activating toll-like receptor 9
by: Xiang-Rong Qin, et al.
Published: (2019-01-01)

Toll‐Like Receptor 9 Plays a Pivotal Role in Angiotensin II–Induced Atherosclerosis
by: Daiju Fukuda, et al.
Published: (2019-04-01)

Identification and characterization of toll-like receptor (TLR) 2 and 4 mutations in colorectal
by: Davoodi, Homa
Published: (2009)

Surface toll-like receptor 9 on immune cells and its immunomodulatory effect
by: Mengyuan Kou, et al.
Published: (2023-09-01)

Interplay of Chemokines Receptors, Toll-like Receptors, and Host Immunological Pathways
by: Yuan-Tung Chu, et al.
Published: (2023-08-01)

CpG-ODN Signaling via Dendritic Cells-Expressing MyD88, but Not IL-10, Inhibits Allergic Sensitization
by: Ricardo Wesley Alberca, et al.
Published: (2021-07-01)

The critical role of Toll-like receptor-mediated signaling in cancer immunotherapy
by: Xue Chen, et al.
Published: (2022-06-01)

Decreased Toll-like Receptor (TLR) 2 and 4 Expression in Spermatozoa in Couples with Unexplained Recurrent Spontaneous Abortion (URSA)
by: Nasrin Sereshki, et al.
Published: (2019-11-01)

Candida and Toll-Like Receptors
by: Şayeste Demirezen, et al.
Published: (2012-12-01)

Emerging roles of Toll-like receptor 9 in cardiometabolic disorders
by: Sachiko Nishimoto, et al.
Published: (2020-07-01)

Prognostic role of Toll-like receptors in cancer: a meta-analysis
by: Wang Q, et al.
Published: (2018-07-01)

Roles of Toll-Like Receptors in Nitroxidative Stress in Mammals
by: Yao Li, et al.
Published: (2019-06-01)

CLINICAL SIGNIFICANCE OF Toll2, Toll4, CD14, AND HLA-DR EXPRESSION ON THE MONOCYTES IN PATIENTS WITH SEPSIS
by: V. A. Lazanovich, et al.
Published: (2015-06-01)