Diuretic resistance in patients with chronic heart failure: mechanisms, prevention, and treatment
The authors analyzed the problem of diuretic resistance (DR) in patients with chronic heart failure (CHF). Most of the symptoms and signs of CHF are associated with hypervolemia and vascular congestion in the systemic and pulmonary circulation. The severity of the latter is the main factor which neg...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Siberian State Medical University (Tomsk)
2022-07-01
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| Series: | Бюллетень сибирской медицины |
| Subjects: | |
| Online Access: | https://bulletin.ssmu.ru/jour/article/view/4826 |
| _version_ | 1797872758258925568 |
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| author | V. V. Kalyuzhin A. T. Teplyakov I. D. Bespalova E. V. Kalyuzhina N. N. Terentyeva I. K. Livshits V. L. Ostanko E. V. Grakova K. V. Kopeva V. Yu. Usov N. P. Garganeeva Yu. V. Gorelova |
| author_facet | V. V. Kalyuzhin A. T. Teplyakov I. D. Bespalova E. V. Kalyuzhina N. N. Terentyeva I. K. Livshits V. L. Ostanko E. V. Grakova K. V. Kopeva V. Yu. Usov N. P. Garganeeva Yu. V. Gorelova |
| author_sort | V. V. Kalyuzhin |
| collection | DOAJ |
| description | The authors analyzed the problem of diuretic resistance (DR) in patients with chronic heart failure (CHF). Most of the symptoms and signs of CHF are associated with hypervolemia and vascular congestion in the systemic and pulmonary circulation. The severity of the latter is the main factor which negatively affects the overall assessment of life satisfaction in patients with CHF. Since the patient, even at the incurable stage of CHF, primarily expects a rapid decrease in the severity of manifestations of decompensation from the prescribed therapy, achieving euvolemia is the essence of its short-term objective. Without diuretics, these immediate effects, according to which most CHF patients judge the qualifications of the doctor, are almost impossible to achieve. Unfortunately, apparently, not a single clinician was able to avoid disappointment in the effectiveness of CHF therapy associated with DR in their practice. As a rule, DR reflects the progressive course of CHF and is often associated with a poor prognosis. The review consistently covers the issues of terminology, diagnosis, pathogenesis, and prevention of DR, which aggravates CHF, and discusses measures aimed at restoring sensitivity to diuretics. |
| first_indexed | 2024-04-10T01:05:15Z |
| format | Article |
| id | doaj.art-5f115b7007404d7eaed8948c1752c0e9 |
| institution | Directory Open Access Journal |
| issn | 1682-0363 1819-3684 |
| language | English |
| last_indexed | 2024-04-10T01:05:15Z |
| publishDate | 2022-07-01 |
| publisher | Siberian State Medical University (Tomsk) |
| record_format | Article |
| series | Бюллетень сибирской медицины |
| spelling | doaj.art-5f115b7007404d7eaed8948c1752c0e92023-03-13T09:58:28ZengSiberian State Medical University (Tomsk)Бюллетень сибирской медицины1682-03631819-36842022-07-0121215216710.20538/1682-0363-2022-2-152-1672902Diuretic resistance in patients with chronic heart failure: mechanisms, prevention, and treatmentV. V. Kalyuzhin0A. T. Teplyakov1I. D. Bespalova2E. V. Kalyuzhina3N. N. Terentyeva4I. K. Livshits5V. L. Ostanko6E. V. Grakova7K. V. Kopeva8V. Yu. Usov9N. P. Garganeeva10Yu. V. Gorelova11Сибирский государственный медицинский университет (СибГМУ)Научно-исследовательский институт (НИИ) кардиологии,Томский национальный исследовательский медицинский центр (НИМЦ) Российской академии наукСибирский государственный медицинский университет (СибГМУ)Сибирский государственный медицинский университет (СибГМУ)Сургутский государственный университет (СурГУ)Сибирский государственный медицинский университет (СибГМУ)Сибирский государственный медицинский университет (СибГМУ)Научно-исследовательский институт (НИИ) кардиологии,Томский национальный исследовательский медицинский центр (НИМЦ) Российской академии наукНаучно-исследовательский институт (НИИ) кардиологии,Томский национальный исследовательский медицинский центр (НИМЦ) Российской академии наукНаучно-исследовательский институт (НИИ) кардиологии,Томский национальный исследовательский медицинский центр (НИМЦ) Российской академии наукСибирский государственный медицинский университет (СибГМУ)Сибирский государственный медицинский университет (СибГМУ)The authors analyzed the problem of diuretic resistance (DR) in patients with chronic heart failure (CHF). Most of the symptoms and signs of CHF are associated with hypervolemia and vascular congestion in the systemic and pulmonary circulation. The severity of the latter is the main factor which negatively affects the overall assessment of life satisfaction in patients with CHF. Since the patient, even at the incurable stage of CHF, primarily expects a rapid decrease in the severity of manifestations of decompensation from the prescribed therapy, achieving euvolemia is the essence of its short-term objective. Without diuretics, these immediate effects, according to which most CHF patients judge the qualifications of the doctor, are almost impossible to achieve. Unfortunately, apparently, not a single clinician was able to avoid disappointment in the effectiveness of CHF therapy associated with DR in their practice. As a rule, DR reflects the progressive course of CHF and is often associated with a poor prognosis. The review consistently covers the issues of terminology, diagnosis, pathogenesis, and prevention of DR, which aggravates CHF, and discusses measures aimed at restoring sensitivity to diuretics.https://bulletin.ssmu.ru/jour/article/view/4826хроническая сердечная недостаточностьрезистентность к диуретикамтерминологиямеханизмыводно-солевой режимсеквенциальная блокада нефронаглифлозинываптаныинотропывазоконстрикторыглюкокортикостероидысерелаксиннесиритидальбуминультрафильтрация |
| spellingShingle | V. V. Kalyuzhin A. T. Teplyakov I. D. Bespalova E. V. Kalyuzhina N. N. Terentyeva I. K. Livshits V. L. Ostanko E. V. Grakova K. V. Kopeva V. Yu. Usov N. P. Garganeeva Yu. V. Gorelova Diuretic resistance in patients with chronic heart failure: mechanisms, prevention, and treatment Бюллетень сибирской медицины хроническая сердечная недостаточность резистентность к диуретикам терминология механизмы водно-солевой режим секвенциальная блокада нефрона глифлозины ваптаны инотропы вазоконстрикторы глюкокортикостероиды серелаксин несиритид альбумин ультрафильтрация |
| title | Diuretic resistance in patients with chronic heart failure: mechanisms, prevention, and treatment |
| title_full | Diuretic resistance in patients with chronic heart failure: mechanisms, prevention, and treatment |
| title_fullStr | Diuretic resistance in patients with chronic heart failure: mechanisms, prevention, and treatment |
| title_full_unstemmed | Diuretic resistance in patients with chronic heart failure: mechanisms, prevention, and treatment |
| title_short | Diuretic resistance in patients with chronic heart failure: mechanisms, prevention, and treatment |
| title_sort | diuretic resistance in patients with chronic heart failure mechanisms prevention and treatment |
| topic | хроническая сердечная недостаточность резистентность к диуретикам терминология механизмы водно-солевой режим секвенциальная блокада нефрона глифлозины ваптаны инотропы вазоконстрикторы глюкокортикостероиды серелаксин несиритид альбумин ультрафильтрация |
| url | https://bulletin.ssmu.ru/jour/article/view/4826 |
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