Association of Age and Sex With Multi-Modal Cerebral Physiology in Adult Moderate/Severe Traumatic Brain Injury: A Narrative Overview and Future Avenues for Personalized Approaches
The impact of age and biological sex on outcome in moderate/severe traumatic brain injury (TBI) has been documented in large cohort studies, with advanced age and male sex linked to worse long-term outcomes. However, the association between age/biological sex and high-frequency continuous multi-moda...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-11-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2021.676154/full |
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| author | C. Batson A. Gomez A. Gomez A. S. Sainbhi L. Froese F. A. Zeiler F. A. Zeiler F. A. Zeiler F. A. Zeiler F. A. Zeiler |
| author_facet | C. Batson A. Gomez A. Gomez A. S. Sainbhi L. Froese F. A. Zeiler F. A. Zeiler F. A. Zeiler F. A. Zeiler F. A. Zeiler |
| author_sort | C. Batson |
| collection | DOAJ |
| description | The impact of age and biological sex on outcome in moderate/severe traumatic brain injury (TBI) has been documented in large cohort studies, with advanced age and male sex linked to worse long-term outcomes. However, the association between age/biological sex and high-frequency continuous multi-modal monitoring (MMM) cerebral physiology is unclear, with only sparing reference made in guidelines and major literature in moderate/severe TBI. In this narrative review, we summarize some of the largest studies associating various high-frequency MMM parameters with age and biological sex in moderate/severe TBI. To start, we present this by highlighting the representative available literature on high-frequency data from Intracranial Pressure (ICP), Cerebral Perfusion Pressure (CPP), Extracellular Brain Tissue Oxygenation (PbtO2), Regional Cerebral Oxygen Saturations (rSO2), Cerebral Blood Flow (CBF), Cerebral Blood Flow Velocity (CBFV), Cerebrovascular Reactivity (CVR), Cerebral Compensatory Reserve, common Cerebral Microdialysis (CMD) Analytes and their correlation to age and sex in moderate/severe TBI cohorts. Then we present current knowledge gaps in the literature, discuss biological implications of age and sex on cerebrovascular monitoring in TBI and some future avenues for bedside research into the cerebrovascular physiome after TBI. |
| first_indexed | 2024-12-18T02:36:30Z |
| format | Article |
| id | doaj.art-5f1205686bc9447a8be2009e072729e3 |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-12-18T02:36:30Z |
| publishDate | 2021-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-5f1205686bc9447a8be2009e072729e32022-12-21T21:23:46ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122021-11-011210.3389/fphar.2021.676154676154Association of Age and Sex With Multi-Modal Cerebral Physiology in Adult Moderate/Severe Traumatic Brain Injury: A Narrative Overview and Future Avenues for Personalized ApproachesC. Batson0A. Gomez1A. Gomez2A. S. Sainbhi3L. Froese4F. A. Zeiler5F. A. Zeiler6F. A. Zeiler7F. A. Zeiler8F. A. Zeiler9Department of Human Anatomy and Cell Science, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, CanadaDepartment of Human Anatomy and Cell Science, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, CanadaSection of Neurosurgery, Department of Surgery, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, CanadaBiomedical Engineering, Faculty of Engineering, University of Manitoba, Winnipeg, MB, CanadaBiomedical Engineering, Faculty of Engineering, University of Manitoba, Winnipeg, MB, CanadaDepartment of Human Anatomy and Cell Science, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, CanadaSection of Neurosurgery, Department of Surgery, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, CanadaBiomedical Engineering, Faculty of Engineering, University of Manitoba, Winnipeg, MB, CanadaCentre on Aging, University of Manitoba, Winnipeg, MB, CanadaDivision of Anaesthesia, Department of Medicine, Addenbrooke’s Hospital, University of Cambridge, Cambridge, United KingdomThe impact of age and biological sex on outcome in moderate/severe traumatic brain injury (TBI) has been documented in large cohort studies, with advanced age and male sex linked to worse long-term outcomes. However, the association between age/biological sex and high-frequency continuous multi-modal monitoring (MMM) cerebral physiology is unclear, with only sparing reference made in guidelines and major literature in moderate/severe TBI. In this narrative review, we summarize some of the largest studies associating various high-frequency MMM parameters with age and biological sex in moderate/severe TBI. To start, we present this by highlighting the representative available literature on high-frequency data from Intracranial Pressure (ICP), Cerebral Perfusion Pressure (CPP), Extracellular Brain Tissue Oxygenation (PbtO2), Regional Cerebral Oxygen Saturations (rSO2), Cerebral Blood Flow (CBF), Cerebral Blood Flow Velocity (CBFV), Cerebrovascular Reactivity (CVR), Cerebral Compensatory Reserve, common Cerebral Microdialysis (CMD) Analytes and their correlation to age and sex in moderate/severe TBI cohorts. Then we present current knowledge gaps in the literature, discuss biological implications of age and sex on cerebrovascular monitoring in TBI and some future avenues for bedside research into the cerebrovascular physiome after TBI.https://www.frontiersin.org/articles/10.3389/fphar.2021.676154/fullagingcerebral physiologysexTBI - traumatic brain injurytraumatic brain injury (craniocerebral trauma) |
| spellingShingle | C. Batson A. Gomez A. Gomez A. S. Sainbhi L. Froese F. A. Zeiler F. A. Zeiler F. A. Zeiler F. A. Zeiler F. A. Zeiler Association of Age and Sex With Multi-Modal Cerebral Physiology in Adult Moderate/Severe Traumatic Brain Injury: A Narrative Overview and Future Avenues for Personalized Approaches Frontiers in Pharmacology aging cerebral physiology sex TBI - traumatic brain injury traumatic brain injury (craniocerebral trauma) |
| title | Association of Age and Sex With Multi-Modal Cerebral Physiology in Adult Moderate/Severe Traumatic Brain Injury: A Narrative Overview and Future Avenues for Personalized Approaches |
| title_full | Association of Age and Sex With Multi-Modal Cerebral Physiology in Adult Moderate/Severe Traumatic Brain Injury: A Narrative Overview and Future Avenues for Personalized Approaches |
| title_fullStr | Association of Age and Sex With Multi-Modal Cerebral Physiology in Adult Moderate/Severe Traumatic Brain Injury: A Narrative Overview and Future Avenues for Personalized Approaches |
| title_full_unstemmed | Association of Age and Sex With Multi-Modal Cerebral Physiology in Adult Moderate/Severe Traumatic Brain Injury: A Narrative Overview and Future Avenues for Personalized Approaches |
| title_short | Association of Age and Sex With Multi-Modal Cerebral Physiology in Adult Moderate/Severe Traumatic Brain Injury: A Narrative Overview and Future Avenues for Personalized Approaches |
| title_sort | association of age and sex with multi modal cerebral physiology in adult moderate severe traumatic brain injury a narrative overview and future avenues for personalized approaches |
| topic | aging cerebral physiology sex TBI - traumatic brain injury traumatic brain injury (craniocerebral trauma) |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2021.676154/full |
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