Combination Therapy with A1 Receptor Agonist and Vitamin C Improved Working Memory in a Mouse Model of Global Ischemia-Reperfusion
Introduction: Stroke is one of the most important reasons of death. Hence, trials to prevent or lessen the complications originated by stroke are a goal of public health worldwide. The ischemia-reperfusion causes hypoxia, hypoglycemia and incomplete repel of metabolic waste products and leads to acc...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Iran University of Medical Sciences
2013-04-01
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| Series: | Basic and Clinical Neuroscience |
| Subjects: | |
| Online Access: | http://bcn.iums.ac.ir/browse.php?a_code=A-10-1-149&slc_lang=en&sid=1 |
| _version_ | 1797280443014316032 |
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| author | Mohmmad Zamani M. Katebi Mehdi Mehdizadeh Laya Kafami Fatemeh Malek Mansooreh Soleimani |
| author_facet | Mohmmad Zamani M. Katebi Mehdi Mehdizadeh Laya Kafami Fatemeh Malek Mansooreh Soleimani |
| author_sort | Mohmmad Zamani |
| collection | DOAJ |
| description | Introduction: Stroke is one of the most important reasons of death. Hence, trials to prevent or lessen the complications originated by stroke are a goal of public health worldwide. The ischemia-reperfusion causes hypoxia, hypoglycemia and incomplete repel of metabolic waste products and leads to accumulation of free radicals triggering neuronal death. The A1 adenosine receptoras an endogenous ligand of adenosine is known to improve cell resistance to destructive agentsby preventing apoptosis. Vitamin C as a cellular antioxidant is also known as an effective factor to reduce damages initiated by free radicals. We studied the protective effects of A1 receptor agonist in combination with vitamin C against ischemia-reperfusion. Methods: Ischemia was induced by common carotid artery occlusion in bulb-c mice (20-30 gr). Y-Maze was employed to scale the short-term memory and Nissl staining was used to count the cells in hippocampus. Results: We found that concurrent treatment of A1 receptor agonist and vitamin C significantly reduced neuronal death in CA1. The Memory scores were also significantly improved (P<0.05). Discussion: Our data point to the therapeutic effects of CPA/vitamin C co-administration and highlight the beneficial role of A1 adenosine receptor signaling in the context of stroke |
| first_indexed | 2024-03-07T16:40:22Z |
| format | Article |
| id | doaj.art-5f17316a4baa4af88c13f318acb612de |
| institution | Directory Open Access Journal |
| issn | 2008-126X 2228-7442 |
| language | English |
| last_indexed | 2024-03-07T16:40:22Z |
| publishDate | 2013-04-01 |
| publisher | Iran University of Medical Sciences |
| record_format | Article |
| series | Basic and Clinical Neuroscience |
| spelling | doaj.art-5f17316a4baa4af88c13f318acb612de2024-03-03T08:32:13ZengIran University of Medical SciencesBasic and Clinical Neuroscience2008-126X2228-74422013-04-0142111116Combination Therapy with A1 Receptor Agonist and Vitamin C Improved Working Memory in a Mouse Model of Global Ischemia-ReperfusionMohmmad Zamani0M. Katebi1Mehdi Mehdizadeh2Laya Kafami3Fatemeh Malek4Mansooreh Soleimani5 Introduction: Stroke is one of the most important reasons of death. Hence, trials to prevent or lessen the complications originated by stroke are a goal of public health worldwide. The ischemia-reperfusion causes hypoxia, hypoglycemia and incomplete repel of metabolic waste products and leads to accumulation of free radicals triggering neuronal death. The A1 adenosine receptoras an endogenous ligand of adenosine is known to improve cell resistance to destructive agentsby preventing apoptosis. Vitamin C as a cellular antioxidant is also known as an effective factor to reduce damages initiated by free radicals. We studied the protective effects of A1 receptor agonist in combination with vitamin C against ischemia-reperfusion. Methods: Ischemia was induced by common carotid artery occlusion in bulb-c mice (20-30 gr). Y-Maze was employed to scale the short-term memory and Nissl staining was used to count the cells in hippocampus. Results: We found that concurrent treatment of A1 receptor agonist and vitamin C significantly reduced neuronal death in CA1. The Memory scores were also significantly improved (P<0.05). Discussion: Our data point to the therapeutic effects of CPA/vitamin C co-administration and highlight the beneficial role of A1 adenosine receptor signaling in the context of strokehttp://bcn.iums.ac.ir/browse.php?a_code=A-10-1-149&slc_lang=en&sid=1Ischemia-ReperfusionHippocampusA1 receptorVitamin C. |
| spellingShingle | Mohmmad Zamani M. Katebi Mehdi Mehdizadeh Laya Kafami Fatemeh Malek Mansooreh Soleimani Combination Therapy with A1 Receptor Agonist and Vitamin C Improved Working Memory in a Mouse Model of Global Ischemia-Reperfusion Basic and Clinical Neuroscience Ischemia-Reperfusion Hippocampus A1 receptor Vitamin C. |
| title | Combination Therapy with A1 Receptor Agonist and Vitamin C Improved Working Memory in a Mouse Model of Global Ischemia-Reperfusion |
| title_full | Combination Therapy with A1 Receptor Agonist and Vitamin C Improved Working Memory in a Mouse Model of Global Ischemia-Reperfusion |
| title_fullStr | Combination Therapy with A1 Receptor Agonist and Vitamin C Improved Working Memory in a Mouse Model of Global Ischemia-Reperfusion |
| title_full_unstemmed | Combination Therapy with A1 Receptor Agonist and Vitamin C Improved Working Memory in a Mouse Model of Global Ischemia-Reperfusion |
| title_short | Combination Therapy with A1 Receptor Agonist and Vitamin C Improved Working Memory in a Mouse Model of Global Ischemia-Reperfusion |
| title_sort | combination therapy with a1 receptor agonist and vitamin c improved working memory in a mouse model of global ischemia reperfusion |
| topic | Ischemia-Reperfusion Hippocampus A1 receptor Vitamin C. |
| url | http://bcn.iums.ac.ir/browse.php?a_code=A-10-1-149&slc_lang=en&sid=1 |
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