Novel Orthopoxvirus and Lethal Disease in Cat, Italy
We report detection and full-genome characterization of a novel orthopoxvirus (OPXV) responsible for a fatal infection in a cat. The virus induced skin lesions histologically characterized by leukocyte infiltration and eosinophilic cytoplasmic inclusions. Different PCR approaches were unable to assi...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Centers for Disease Control and Prevention
2018-09-01
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| Series: | Emerging Infectious Diseases |
| Subjects: | |
| Online Access: | https://wwwnc.cdc.gov/eid/article/24/9/17-1283_article |
| _version_ | 1823937703373176832 |
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| author | Gianvito Lanave Giulia Dowgier Nicola Decaro Francesco Albanese Elisa Brogi Antonio Parisi Michele Losurdo Antonio Lavazza Vito Martella Canio Buonavoglia Gabriella Elia |
| author_facet | Gianvito Lanave Giulia Dowgier Nicola Decaro Francesco Albanese Elisa Brogi Antonio Parisi Michele Losurdo Antonio Lavazza Vito Martella Canio Buonavoglia Gabriella Elia |
| author_sort | Gianvito Lanave |
| collection | DOAJ |
| description | We report detection and full-genome characterization of a novel orthopoxvirus (OPXV) responsible for a fatal infection in a cat. The virus induced skin lesions histologically characterized by leukocyte infiltration and eosinophilic cytoplasmic inclusions. Different PCR approaches were unable to assign the virus to a defined OPXV species. Large amounts of typical brick-shaped virions, morphologically related to OPXV, were observed by electron microscopy. This OPXV strain (Italy_09/17) was isolated on cell cultures and embryonated eggs. Phylogenetic analysis of 9 concatenated genes showed that this virus was distantly related to cowpox virus, more closely related to to ectromelia virus, and belonged to the same cluster of an OPXV recently isolated from captive macaques in Italy. Extensive epidemiologic surveillance in cats and rodents will assess whether cats are incidental hosts and rodents are the main reservoir of the virus. The zoonotic potential of this novel virus also deserves further investigation. |
| first_indexed | 2024-12-17T02:05:32Z |
| format | Article |
| id | doaj.art-5f18a433603a4d7790f37b642f3ac180 |
| institution | Directory Open Access Journal |
| issn | 1080-6040 1080-6059 |
| language | English |
| last_indexed | 2024-12-17T02:05:32Z |
| publishDate | 2018-09-01 |
| publisher | Centers for Disease Control and Prevention |
| record_format | Article |
| series | Emerging Infectious Diseases |
| spelling | doaj.art-5f18a433603a4d7790f37b642f3ac1802022-12-21T22:07:42ZengCenters for Disease Control and PreventionEmerging Infectious Diseases1080-60401080-60592018-09-012491665167310.3201/eid2409.171283Novel Orthopoxvirus and Lethal Disease in Cat, ItalyGianvito LanaveGiulia DowgierNicola DecaroFrancesco AlbaneseElisa BrogiAntonio ParisiMichele LosurdoAntonio LavazzaVito MartellaCanio BuonavogliaGabriella EliaWe report detection and full-genome characterization of a novel orthopoxvirus (OPXV) responsible for a fatal infection in a cat. The virus induced skin lesions histologically characterized by leukocyte infiltration and eosinophilic cytoplasmic inclusions. Different PCR approaches were unable to assign the virus to a defined OPXV species. Large amounts of typical brick-shaped virions, morphologically related to OPXV, were observed by electron microscopy. This OPXV strain (Italy_09/17) was isolated on cell cultures and embryonated eggs. Phylogenetic analysis of 9 concatenated genes showed that this virus was distantly related to cowpox virus, more closely related to to ectromelia virus, and belonged to the same cluster of an OPXV recently isolated from captive macaques in Italy. Extensive epidemiologic surveillance in cats and rodents will assess whether cats are incidental hosts and rodents are the main reservoir of the virus. The zoonotic potential of this novel virus also deserves further investigation.https://wwwnc.cdc.gov/eid/article/24/9/17-1283_articlecatnovel orthopoxvirusorthopoxvirusviruseslethal diseasenext-generation sequencing |
| spellingShingle | Gianvito Lanave Giulia Dowgier Nicola Decaro Francesco Albanese Elisa Brogi Antonio Parisi Michele Losurdo Antonio Lavazza Vito Martella Canio Buonavoglia Gabriella Elia Novel Orthopoxvirus and Lethal Disease in Cat, Italy Emerging Infectious Diseases cat novel orthopoxvirus orthopoxvirus viruses lethal disease next-generation sequencing |
| title | Novel Orthopoxvirus and Lethal Disease in Cat, Italy |
| title_full | Novel Orthopoxvirus and Lethal Disease in Cat, Italy |
| title_fullStr | Novel Orthopoxvirus and Lethal Disease in Cat, Italy |
| title_full_unstemmed | Novel Orthopoxvirus and Lethal Disease in Cat, Italy |
| title_short | Novel Orthopoxvirus and Lethal Disease in Cat, Italy |
| title_sort | novel orthopoxvirus and lethal disease in cat italy |
| topic | cat novel orthopoxvirus orthopoxvirus viruses lethal disease next-generation sequencing |
| url | https://wwwnc.cdc.gov/eid/article/24/9/17-1283_article |
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