Assessment of Biventricular Myocardial Function with 2-Dimensional Strain and Conventional Echocardiographic Parameters: A Comparative Analysis in Healthy Infants and Patients with Severe and Critical Pulmonary Stenosis
Our aim was to compare the global longitudinal and regional biventricular strain between infants with severe and critical pulmonary stenosis (PS), and controls; to compare pre- and post-procedural strain values in infants with severe and critical PS; and to assess the correlations between echocardio...
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MDPI AG
2022-01-01
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| Series: | Journal of Personalized Medicine |
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| Online Access: | https://www.mdpi.com/2075-4426/12/1/57 |
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| author | Liliana Gozar Mihaela Iancu Horea Gozar Anca Sglimbea Andreea Cerghit Paler Dorottya Gabor-Miklosi Rodica Toganel Amalia Făgărășan Diana Ramona Iurian Daniela Toma |
| author_facet | Liliana Gozar Mihaela Iancu Horea Gozar Anca Sglimbea Andreea Cerghit Paler Dorottya Gabor-Miklosi Rodica Toganel Amalia Făgărășan Diana Ramona Iurian Daniela Toma |
| author_sort | Liliana Gozar |
| collection | DOAJ |
| description | Our aim was to compare the global longitudinal and regional biventricular strain between infants with severe and critical pulmonary stenosis (PS), and controls; to compare pre- and post-procedural strain values in infants with severe and critical PS; and to assess the correlations between echocardiographic strain and conventional parameters. We conducted a retrospective single-center study. The comparisons of echocardiographic variables were performed using separate linear mixed models. The overall mean right ventricle (RV) regional strains measured before intervention in PS patients was significantly different when compared to the control group (<i>p</i> = 0.0324). We found a significant change in the left ventricle, RV, and inter-ventricular septum strain (IVS) values from basal to apical location (<i>p</i> < 0.05). IVS strain values showed a higher decrease in mean strain values from basal to apical in PS patients. There was no significant difference in means of baseline and post-interventional strain values in PS patients (<i>p</i> > 0.05). Following the strain analysis in patients with PS, we obtained statistically significant changes in the RV global-4-chamber longitudinal strain (RV4C). The RV4C, which quantifies the longitudinal strain to the entire RV, can be used in current clinical practice for the evaluation of RV function in infants with severe and critical PS. The longitudinal and segmental strain capture the pathological changes in the IVS, modifications that cannot be highlighted through a classical echocardiographic evaluation. |
| first_indexed | 2024-03-10T01:09:17Z |
| format | Article |
| id | doaj.art-5f198d8bf1474dd994ed1c9224edb907 |
| institution | Directory Open Access Journal |
| issn | 2075-4426 |
| language | English |
| last_indexed | 2024-03-10T01:09:17Z |
| publishDate | 2022-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Personalized Medicine |
| spelling | doaj.art-5f198d8bf1474dd994ed1c9224edb9072023-11-23T14:19:51ZengMDPI AGJournal of Personalized Medicine2075-44262022-01-011215710.3390/jpm12010057Assessment of Biventricular Myocardial Function with 2-Dimensional Strain and Conventional Echocardiographic Parameters: A Comparative Analysis in Healthy Infants and Patients with Severe and Critical Pulmonary StenosisLiliana Gozar0Mihaela Iancu1Horea Gozar2Anca Sglimbea3Andreea Cerghit Paler4Dorottya Gabor-Miklosi5Rodica Toganel6Amalia Făgărășan7Diana Ramona Iurian8Daniela Toma9Emergency Institute of Cardiovascular Diseases and Transplantation, 540139 Târgu-Mureș, RomaniaDepartment of Medical Informatics and Biostatistics, Faculty of Medicine, “Iuliu Hațieganu” University of Medicine and Pharmacy Cluj-Napoca, 400012 Cluj-Napoca, RomaniaDepartment of Pediatric Surgery, “George Emil Palade” University of Medicine, Pharmacy, Science and Technology of Târgu-Mureș, 540139 Târgu-Mureș, RomaniaEmergency Institute of Cardiovascular Diseases and Transplantation, 540139 Târgu-Mureș, RomaniaEmergency Institute of Cardiovascular Diseases and Transplantation, 540139 Târgu-Mureș, RomaniaEmergency Institute of Cardiovascular Diseases and Transplantation, 540139 Târgu-Mureș, RomaniaEmergency Institute of Cardiovascular Diseases and Transplantation, 540139 Târgu-Mureș, RomaniaEmergency Institute of Cardiovascular Diseases and Transplantation, 540139 Târgu-Mureș, RomaniaEmergency Institute of Cardiovascular Diseases and Transplantation, 540139 Târgu-Mureș, RomaniaEmergency Institute of Cardiovascular Diseases and Transplantation, 540139 Târgu-Mureș, RomaniaOur aim was to compare the global longitudinal and regional biventricular strain between infants with severe and critical pulmonary stenosis (PS), and controls; to compare pre- and post-procedural strain values in infants with severe and critical PS; and to assess the correlations between echocardiographic strain and conventional parameters. We conducted a retrospective single-center study. The comparisons of echocardiographic variables were performed using separate linear mixed models. The overall mean right ventricle (RV) regional strains measured before intervention in PS patients was significantly different when compared to the control group (<i>p</i> = 0.0324). We found a significant change in the left ventricle, RV, and inter-ventricular septum strain (IVS) values from basal to apical location (<i>p</i> < 0.05). IVS strain values showed a higher decrease in mean strain values from basal to apical in PS patients. There was no significant difference in means of baseline and post-interventional strain values in PS patients (<i>p</i> > 0.05). Following the strain analysis in patients with PS, we obtained statistically significant changes in the RV global-4-chamber longitudinal strain (RV4C). The RV4C, which quantifies the longitudinal strain to the entire RV, can be used in current clinical practice for the evaluation of RV function in infants with severe and critical PS. The longitudinal and segmental strain capture the pathological changes in the IVS, modifications that cannot be highlighted through a classical echocardiographic evaluation.https://www.mdpi.com/2075-4426/12/1/57pulmonary stenosisspeckle trackingmyocardial straininfantsechocardiography |
| spellingShingle | Liliana Gozar Mihaela Iancu Horea Gozar Anca Sglimbea Andreea Cerghit Paler Dorottya Gabor-Miklosi Rodica Toganel Amalia Făgărășan Diana Ramona Iurian Daniela Toma Assessment of Biventricular Myocardial Function with 2-Dimensional Strain and Conventional Echocardiographic Parameters: A Comparative Analysis in Healthy Infants and Patients with Severe and Critical Pulmonary Stenosis Journal of Personalized Medicine pulmonary stenosis speckle tracking myocardial strain infants echocardiography |
| title | Assessment of Biventricular Myocardial Function with 2-Dimensional Strain and Conventional Echocardiographic Parameters: A Comparative Analysis in Healthy Infants and Patients with Severe and Critical Pulmonary Stenosis |
| title_full | Assessment of Biventricular Myocardial Function with 2-Dimensional Strain and Conventional Echocardiographic Parameters: A Comparative Analysis in Healthy Infants and Patients with Severe and Critical Pulmonary Stenosis |
| title_fullStr | Assessment of Biventricular Myocardial Function with 2-Dimensional Strain and Conventional Echocardiographic Parameters: A Comparative Analysis in Healthy Infants and Patients with Severe and Critical Pulmonary Stenosis |
| title_full_unstemmed | Assessment of Biventricular Myocardial Function with 2-Dimensional Strain and Conventional Echocardiographic Parameters: A Comparative Analysis in Healthy Infants and Patients with Severe and Critical Pulmonary Stenosis |
| title_short | Assessment of Biventricular Myocardial Function with 2-Dimensional Strain and Conventional Echocardiographic Parameters: A Comparative Analysis in Healthy Infants and Patients with Severe and Critical Pulmonary Stenosis |
| title_sort | assessment of biventricular myocardial function with 2 dimensional strain and conventional echocardiographic parameters a comparative analysis in healthy infants and patients with severe and critical pulmonary stenosis |
| topic | pulmonary stenosis speckle tracking myocardial strain infants echocardiography |
| url | https://www.mdpi.com/2075-4426/12/1/57 |
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