Effect of Cod Residual Protein Supplementation on Markers of Glucose Regulation in Lean Adults: A Randomized Double-Blind Study
Large quantities of protein-rich cod residuals, which are currently discarded, could be utilized for human consumption. Although fish fillet intake is related to beneficial health effects, little is known about the potential health effects of consuming cod residual protein powder. Fifty lean adults...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-05-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/12/5/1445 |
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| author | Iselin Vildmyren Alfred Halstensen Adrian McCann Øivind Midttun Per Magne Ueland Åge Oterhals Oddrun Anita Gudbrandsen |
| author_facet | Iselin Vildmyren Alfred Halstensen Adrian McCann Øivind Midttun Per Magne Ueland Åge Oterhals Oddrun Anita Gudbrandsen |
| author_sort | Iselin Vildmyren |
| collection | DOAJ |
| description | Large quantities of protein-rich cod residuals, which are currently discarded, could be utilized for human consumption. Although fish fillet intake is related to beneficial health effects, little is known about the potential health effects of consuming cod residual protein powder. Fifty lean adults were randomized to consume capsules with 8.1 g/day of cod residual protein (Cod-RP) or placebo capsules (Control group) for eight weeks, in this randomized, double-blind study. The intervention was completed by 40 participants. Fasting glucose and insulin concentrations were unaffected by Cod-RP supplementation, whereas plasma concentrations of α-hydroxybutyrate, β-hydroxybutyrate and acetoacetate all were decreased compared with the Control group. Trimethylamine N-oxide concentration in plasma and urine were increased in the Cod-RP group compared with the Control group. To conclude, the reduction in these potential early markers of impaired glucose metabolism following Cod-RP supplementation may indicate beneficial glucoregulatory effects of cod residual proteins. Trimethylamine N-oxide appears to be an appropriate biomarker of cod residual protein intake in lean adults. |
| first_indexed | 2024-03-10T19:47:35Z |
| format | Article |
| id | doaj.art-5f1aac5d757d466ea3544f0702007203 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-10T19:47:35Z |
| publishDate | 2020-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-5f1aac5d757d466ea3544f07020072032023-11-20T00:42:38ZengMDPI AGNutrients2072-66432020-05-01125144510.3390/nu12051445Effect of Cod Residual Protein Supplementation on Markers of Glucose Regulation in Lean Adults: A Randomized Double-Blind StudyIselin Vildmyren0Alfred Halstensen1Adrian McCann2Øivind Midttun3Per Magne Ueland4Åge Oterhals5Oddrun Anita Gudbrandsen6Dietary Protein Research Group, Department of Clinical Medicine, University of Bergen, 5021 Bergen, NorwayK. Halstensen AS, P.O. Box 103, 5399 Bekkjarvik, NorwayBevital AS, Jonas Lies veg 87, 5021 Bergen, NorwayBevital AS, Jonas Lies veg 87, 5021 Bergen, NorwayBevital AS, Jonas Lies veg 87, 5021 Bergen, NorwayNofima, P.B. 1425 Oasen, 5844 Bergen, NorwayDietary Protein Research Group, Department of Clinical Medicine, University of Bergen, 5021 Bergen, NorwayLarge quantities of protein-rich cod residuals, which are currently discarded, could be utilized for human consumption. Although fish fillet intake is related to beneficial health effects, little is known about the potential health effects of consuming cod residual protein powder. Fifty lean adults were randomized to consume capsules with 8.1 g/day of cod residual protein (Cod-RP) or placebo capsules (Control group) for eight weeks, in this randomized, double-blind study. The intervention was completed by 40 participants. Fasting glucose and insulin concentrations were unaffected by Cod-RP supplementation, whereas plasma concentrations of α-hydroxybutyrate, β-hydroxybutyrate and acetoacetate all were decreased compared with the Control group. Trimethylamine N-oxide concentration in plasma and urine were increased in the Cod-RP group compared with the Control group. To conclude, the reduction in these potential early markers of impaired glucose metabolism following Cod-RP supplementation may indicate beneficial glucoregulatory effects of cod residual proteins. Trimethylamine N-oxide appears to be an appropriate biomarker of cod residual protein intake in lean adults.https://www.mdpi.com/2072-6643/12/5/1445dietary supplementsfish proteinmarine proteinhydroxybutyrateTMAObiomarkers |
| spellingShingle | Iselin Vildmyren Alfred Halstensen Adrian McCann Øivind Midttun Per Magne Ueland Åge Oterhals Oddrun Anita Gudbrandsen Effect of Cod Residual Protein Supplementation on Markers of Glucose Regulation in Lean Adults: A Randomized Double-Blind Study Nutrients dietary supplements fish protein marine protein hydroxybutyrate TMAO biomarkers |
| title | Effect of Cod Residual Protein Supplementation on Markers of Glucose Regulation in Lean Adults: A Randomized Double-Blind Study |
| title_full | Effect of Cod Residual Protein Supplementation on Markers of Glucose Regulation in Lean Adults: A Randomized Double-Blind Study |
| title_fullStr | Effect of Cod Residual Protein Supplementation on Markers of Glucose Regulation in Lean Adults: A Randomized Double-Blind Study |
| title_full_unstemmed | Effect of Cod Residual Protein Supplementation on Markers of Glucose Regulation in Lean Adults: A Randomized Double-Blind Study |
| title_short | Effect of Cod Residual Protein Supplementation on Markers of Glucose Regulation in Lean Adults: A Randomized Double-Blind Study |
| title_sort | effect of cod residual protein supplementation on markers of glucose regulation in lean adults a randomized double blind study |
| topic | dietary supplements fish protein marine protein hydroxybutyrate TMAO biomarkers |
| url | https://www.mdpi.com/2072-6643/12/5/1445 |
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