Autologous antigen-presenting cells efficiently expand piggyBac transposon CAR-T cells with predominant memory phenotype

Autologous antigen-presenting cells efficiently expand piggyBac transposon CAR-T cells with predominant memory phenotype

The quality of chimeric antigen receptor (CAR)-T cell products, including the expression of memory and exhaustion markers, has been shown to influence their long-term functionality. The manufacturing process of CAR-T cells should be optimized to prevent early T cell exhaustion during expansion. Acti...

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Bibliographic Details
Main Authors: Kayoko Nakamura, Shigeki Yagyu, Shogo Hirota, Akimasa Tomida, Makoto Kondo, Tomokuni Shigeura, Aiko Hasegawa, Miyuki Tanaka, Yozo Nakazawa
Format: Article
Language:English
Published: Elsevier 2021-06-01
Series:Molecular Therapy: Methods & Clinical Development
Subjects:
chimeric antigen receptor T cells
piggyBac transposon
HER2
early T cell exhaustion
T stem cell memory-like cells
electroporation
Online Access:http://www.sciencedirect.com/science/article/pii/S2329050121000516

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