Increased Blood Pressure Variability Prior to Chronic Kidney Disease Exacerbates Renal Dysfunction in Rats
Increased blood pressure variability (BPV), which can be experimentally induced by sinoaortic denervation (SAD), has emerged as a new marker of the prognosis of cardiovascular and renal outcomes. Considering that increased BPV can lead to organ-damage, the goal of the present study was to evaluate t...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2016-09-01
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| Series: | Frontiers in Physiology |
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| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fphys.2016.00428/full |
| _version_ | 1818017981821616128 |
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| author | Frederico Felipe Costa Tebas Freitas Gilberto Araujo Marcella Leite Porto Flavia Priscila Santos Freitas Jones Bernardes Graceli Camille Moura Balarini Elisardo Corral Vasquez Elisardo Corral Vasquez Silvana Santos Meyrelles Agata Lages Gava Agata Lages Gava |
| author_facet | Frederico Felipe Costa Tebas Freitas Gilberto Araujo Marcella Leite Porto Flavia Priscila Santos Freitas Jones Bernardes Graceli Camille Moura Balarini Elisardo Corral Vasquez Elisardo Corral Vasquez Silvana Santos Meyrelles Agata Lages Gava Agata Lages Gava |
| author_sort | Frederico Felipe Costa Tebas Freitas |
| collection | DOAJ |
| description | Increased blood pressure variability (BPV), which can be experimentally induced by sinoaortic denervation (SAD), has emerged as a new marker of the prognosis of cardiovascular and renal outcomes. Considering that increased BPV can lead to organ-damage, the goal of the present study was to evaluate the effects of SAD on renal function in an experimental model of chronic kidney disease (CKD). SAD was performed in male Wistar rats 2 weeks before 5/6 nephrectomy and the animals were evaluated 4 weeks after the induction of CKD. Our data demonstrated that BPV was increased in SAD and CKD animals and that the combination of both conditions (SAD+CKD) exacerbated BPV. The baroreflex sensitivity index was diminished in the SAD and CKD groups; this reduction was more pronounced when SAD and CKD were performed together. 5/6 nephrectomy led to hypertension, which was higher in SAD+CKD animals. Regarding renal function, the combination of SAD and CKD resulted in reduced renal plasma and blood flow, increased renal vascular resistance and augmented uraemia when compared to CKD animals. Glomerular filtration rate and BPV were negatively correlated in SAD, CKD and SAD+CKD animals. Moreover, SAD+CKD animals presented a higher level of glomerulosclerosis when compared to all other groups. Cardiac and renal hypertrophy, as well as oxidative stress, was also further increased when SAD and CKD were combined. These results show that SAD prior to 5/6 nephrectomy exacerbates renal dysfunction, suggesting that previous augmented BPV should be considered as an important factor to the progression of renal diseases. |
| first_indexed | 2024-04-14T07:32:53Z |
| format | Article |
| id | doaj.art-5f1c54362e65416aa941696f74e3afc8 |
| institution | Directory Open Access Journal |
| issn | 1664-042X |
| language | English |
| last_indexed | 2024-04-14T07:32:53Z |
| publishDate | 2016-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physiology |
| spelling | doaj.art-5f1c54362e65416aa941696f74e3afc82022-12-22T02:05:46ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2016-09-01710.3389/fphys.2016.00428208327Increased Blood Pressure Variability Prior to Chronic Kidney Disease Exacerbates Renal Dysfunction in RatsFrederico Felipe Costa Tebas Freitas0Gilberto Araujo1Marcella Leite Porto2Flavia Priscila Santos Freitas3Jones Bernardes Graceli4Camille Moura Balarini5Elisardo Corral Vasquez6Elisardo Corral Vasquez7Silvana Santos Meyrelles8Agata Lages Gava9Agata Lages Gava10Federal University of Espirito SantoFederal University of Espirito SantoFederal University of Espirito SantoFederal University of Espirito SantoFederal University of Espirito SantoFederal University of ParaibaFederal University of Espirito SantoUniversity of Vila VelhaFederal University of Espirito SantoFederal University of Espirito SantoMcMaster UniversityIncreased blood pressure variability (BPV), which can be experimentally induced by sinoaortic denervation (SAD), has emerged as a new marker of the prognosis of cardiovascular and renal outcomes. Considering that increased BPV can lead to organ-damage, the goal of the present study was to evaluate the effects of SAD on renal function in an experimental model of chronic kidney disease (CKD). SAD was performed in male Wistar rats 2 weeks before 5/6 nephrectomy and the animals were evaluated 4 weeks after the induction of CKD. Our data demonstrated that BPV was increased in SAD and CKD animals and that the combination of both conditions (SAD+CKD) exacerbated BPV. The baroreflex sensitivity index was diminished in the SAD and CKD groups; this reduction was more pronounced when SAD and CKD were performed together. 5/6 nephrectomy led to hypertension, which was higher in SAD+CKD animals. Regarding renal function, the combination of SAD and CKD resulted in reduced renal plasma and blood flow, increased renal vascular resistance and augmented uraemia when compared to CKD animals. Glomerular filtration rate and BPV were negatively correlated in SAD, CKD and SAD+CKD animals. Moreover, SAD+CKD animals presented a higher level of glomerulosclerosis when compared to all other groups. Cardiac and renal hypertrophy, as well as oxidative stress, was also further increased when SAD and CKD were combined. These results show that SAD prior to 5/6 nephrectomy exacerbates renal dysfunction, suggesting that previous augmented BPV should be considered as an important factor to the progression of renal diseases.http://journal.frontiersin.org/Journal/10.3389/fphys.2016.00428/fullblood pressure variabilityChronic Kidney DiseaseRenal function5/6 nephrectomySinoaortic denervation |
| spellingShingle | Frederico Felipe Costa Tebas Freitas Gilberto Araujo Marcella Leite Porto Flavia Priscila Santos Freitas Jones Bernardes Graceli Camille Moura Balarini Elisardo Corral Vasquez Elisardo Corral Vasquez Silvana Santos Meyrelles Agata Lages Gava Agata Lages Gava Increased Blood Pressure Variability Prior to Chronic Kidney Disease Exacerbates Renal Dysfunction in Rats Frontiers in Physiology blood pressure variability Chronic Kidney Disease Renal function 5/6 nephrectomy Sinoaortic denervation |
| title | Increased Blood Pressure Variability Prior to Chronic Kidney Disease Exacerbates Renal Dysfunction in Rats |
| title_full | Increased Blood Pressure Variability Prior to Chronic Kidney Disease Exacerbates Renal Dysfunction in Rats |
| title_fullStr | Increased Blood Pressure Variability Prior to Chronic Kidney Disease Exacerbates Renal Dysfunction in Rats |
| title_full_unstemmed | Increased Blood Pressure Variability Prior to Chronic Kidney Disease Exacerbates Renal Dysfunction in Rats |
| title_short | Increased Blood Pressure Variability Prior to Chronic Kidney Disease Exacerbates Renal Dysfunction in Rats |
| title_sort | increased blood pressure variability prior to chronic kidney disease exacerbates renal dysfunction in rats |
| topic | blood pressure variability Chronic Kidney Disease Renal function 5/6 nephrectomy Sinoaortic denervation |
| url | http://journal.frontiersin.org/Journal/10.3389/fphys.2016.00428/full |
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