Metallo-β-Lactamase Inhibitors Inspired on Snapshots from the Catalytic Mechanism

Metallo-β-Lactamase Inhibitors Inspired on Snapshots from the Catalytic Mechanism

β-Lactam antibiotics are the most widely prescribed antibacterial drugs due to their low toxicity and broad spectrum. Their action is counteracted by different resistance mechanisms developed by bacteria. Among them, the most common strategy is the expression of β-lactamases, enzymes that hydrolyze...

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Bibliographic Details
Main Authors: Antonela R. Palacios, María-Agustina Rossi, Graciela S. Mahler, Alejandro J. Vila
Format: Article
Language:English
Published: MDPI AG 2020-06-01
Series:Biomolecules
Subjects:
metallo-β-lactamases
mechanism-based inhibitors
antibiotic resistance
reaction mechanism
Online Access:https://www.mdpi.com/2218-273X/10/6/854

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