Association between systemic immunity-inflammation index and hypertension in US adults from NHANES 1999–2018
Abstract Hypertension is a disease closely related to inflammation, and the systemic immunity-inflammation index (SII) is a new and easily detectable inflammatory marker. We aimed to investigate the association between SII and hypertension risk in a adult population in the US. We utilized data from...
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Nature Portfolio
2024-03-01
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| Series: | Scientific Reports |
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| Online Access: | https://doi.org/10.1038/s41598-024-56387-6 |
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| author | Ying Chen Yanping Li Mengqiong Liu Wenxing Xu Shan Tong Kai Liu |
| author_facet | Ying Chen Yanping Li Mengqiong Liu Wenxing Xu Shan Tong Kai Liu |
| author_sort | Ying Chen |
| collection | DOAJ |
| description | Abstract Hypertension is a disease closely related to inflammation, and the systemic immunity-inflammation index (SII) is a new and easily detectable inflammatory marker. We aimed to investigate the association between SII and hypertension risk in a adult population in the US. We utilized data from the National Health and Nutrition Examination Survey spanning from 1999 to 2018, incorporating comprehensive information from adults reporting hypertension. This included details on blood pressure monitoring, complete blood cell counts, and standard biochemical results. The SII was computed as the platelet count multiplied by the neutrophil count divided by the lymphocyte count. We employed a weighted multivariate logistic regression model to examine the correlation between SII and hypertension. Subgroup analyses were conducted to explore potential influencing factors. Furthermore, smooth curve fitting and two-piecewise logistic regression analysis were employed to describe non-linear relationships and identify inflection points. This population-based study involved 44,070 adults aged 20–85 years. Following Ln-transformation of the SII, multivariable logistic regression revealed that, in a fully adjusted model, participants in the highest quartile of Ln(SII) had a 12% increased risk of hypertension compared to those in the lowest quartile, which was statistically significant (OR:1.12; 95% CI 1.01, 1.24; P < 0.001), with a P for trend = 0.019. Subgroup analysis indicated no significant interactions between Ln(SII) and specific subgroups except for the body mass index subgroup (all P for interaction > 0.05). Additionally, the association between Ln(SII) and hypertension displayed a U-shaped curve, with an inflection point at 5.89 (1000 cells/μl). Based on this research result, we found a U-shaped correlation between elevated SII levels and hypertension risk in American adults, with a inflection point of 5.89 (1000 cells)/μl). To validate these findings, larger scale prospective surveys are needed to support the results of this study and investigate potential mechanisms. |
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| language | English |
| last_indexed | 2024-04-25T01:07:02Z |
| publishDate | 2024-03-01 |
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| spelling | doaj.art-5f1c93f84b4d4673a90a6034772a939a2024-03-10T12:10:43ZengNature PortfolioScientific Reports2045-23222024-03-0114111110.1038/s41598-024-56387-6Association between systemic immunity-inflammation index and hypertension in US adults from NHANES 1999–2018Ying Chen0Yanping Li1Mengqiong Liu2Wenxing Xu3Shan Tong4Kai Liu5Medical Laboratory Center, Hainan General Hospital (Hainan Affiliated Hospital of Hainan Medical University)Hainan General Hospital (Hainan Affiliated Hospital of Hainan Medical University)Medical Laboratory Center, Hainan General Hospital (Hainan Affiliated Hospital of Hainan Medical University)Geriatric Center, Hainan General Hospital (Hainan Affiliated Hospital of Hainan Medical University)Geriatric Center, Hainan General Hospital (Hainan Affiliated Hospital of Hainan Medical University)Geriatric Center, Hainan General Hospital (Hainan Affiliated Hospital of Hainan Medical University)Abstract Hypertension is a disease closely related to inflammation, and the systemic immunity-inflammation index (SII) is a new and easily detectable inflammatory marker. We aimed to investigate the association between SII and hypertension risk in a adult population in the US. We utilized data from the National Health and Nutrition Examination Survey spanning from 1999 to 2018, incorporating comprehensive information from adults reporting hypertension. This included details on blood pressure monitoring, complete blood cell counts, and standard biochemical results. The SII was computed as the platelet count multiplied by the neutrophil count divided by the lymphocyte count. We employed a weighted multivariate logistic regression model to examine the correlation between SII and hypertension. Subgroup analyses were conducted to explore potential influencing factors. Furthermore, smooth curve fitting and two-piecewise logistic regression analysis were employed to describe non-linear relationships and identify inflection points. This population-based study involved 44,070 adults aged 20–85 years. Following Ln-transformation of the SII, multivariable logistic regression revealed that, in a fully adjusted model, participants in the highest quartile of Ln(SII) had a 12% increased risk of hypertension compared to those in the lowest quartile, which was statistically significant (OR:1.12; 95% CI 1.01, 1.24; P < 0.001), with a P for trend = 0.019. Subgroup analysis indicated no significant interactions between Ln(SII) and specific subgroups except for the body mass index subgroup (all P for interaction > 0.05). Additionally, the association between Ln(SII) and hypertension displayed a U-shaped curve, with an inflection point at 5.89 (1000 cells/μl). Based on this research result, we found a U-shaped correlation between elevated SII levels and hypertension risk in American adults, with a inflection point of 5.89 (1000 cells)/μl). To validate these findings, larger scale prospective surveys are needed to support the results of this study and investigate potential mechanisms.https://doi.org/10.1038/s41598-024-56387-6Systemic immunity-inflammation indexHigh blood pressureNHANESRisk factorsWeighted logistic regression |
| spellingShingle | Ying Chen Yanping Li Mengqiong Liu Wenxing Xu Shan Tong Kai Liu Association between systemic immunity-inflammation index and hypertension in US adults from NHANES 1999–2018 Scientific Reports Systemic immunity-inflammation index High blood pressure NHANES Risk factors Weighted logistic regression |
| title | Association between systemic immunity-inflammation index and hypertension in US adults from NHANES 1999–2018 |
| title_full | Association between systemic immunity-inflammation index and hypertension in US adults from NHANES 1999–2018 |
| title_fullStr | Association between systemic immunity-inflammation index and hypertension in US adults from NHANES 1999–2018 |
| title_full_unstemmed | Association between systemic immunity-inflammation index and hypertension in US adults from NHANES 1999–2018 |
| title_short | Association between systemic immunity-inflammation index and hypertension in US adults from NHANES 1999–2018 |
| title_sort | association between systemic immunity inflammation index and hypertension in us adults from nhanes 1999 2018 |
| topic | Systemic immunity-inflammation index High blood pressure NHANES Risk factors Weighted logistic regression |
| url | https://doi.org/10.1038/s41598-024-56387-6 |
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