Effect of combined nicotinamide, acetyl-L-carnitine and α-lipoic acid action on separate links of carbohydrate metabolism under experimental type 2 diabetes
The effect of nicotinamide, acetyl-L-carnitine and α-lipoic acid on the separate links of carbohydrate metabolism in the brain, heart and liver of rats for type 2 diabetes it was investigated. Combined administration of nicotinamide, acetyl-L-carnitine and α-lipoic acid caused partial reduction of h...
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| Format: | Article |
| Language: | English |
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Львівський національний університет імені Івана Франка
2014-12-01
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| Series: | Біологічні студії |
| Subjects: | |
| Online Access: | http://publications.lnu.edu.ua/journals/index.php/biology/article/view/195 |
| _version_ | 1819113216691666944 |
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| author | Iu. T. Sergiichuk T. M. Tykhonenko M. M. Guzyk L. V. Yanitska T. M. Kuchmerovska |
| author_facet | Iu. T. Sergiichuk T. M. Tykhonenko M. M. Guzyk L. V. Yanitska T. M. Kuchmerovska |
| author_sort | Iu. T. Sergiichuk |
| collection | DOAJ |
| description | The effect of nicotinamide, acetyl-L-carnitine and α-lipoic acid on the separate links of carbohydrate metabolism in the brain, heart and liver of rats for type 2 diabetes it was investigated. Combined administration of nicotinamide, acetyl-L-carnitine and α-lipoic acid caused partial reduction of hyperglycemia in rats. By the action of investigated compounds activity of hexokinase and glucokinase, which were reduced under diabetes by 62 and 84 %, respectively, as compared to control was partially normalized. NAD contents in brain, heart and liver of diabetic rats were decreased by 46, 52 and 36 %, but were elevated by investigated compounds, especially in liver. It was found that ratio of free NAD/NADH and NADP/NADPH couples under diabetes were decreased in brain, liver and heart as compared to control. Redox-states in these tissues were significantly normalized by investigated compounds. Amino acid concentrations in blood serum of rats were altered and partially normalized by investigated compounds. Thus, combined effect of investigated compounds is more effective and can be used for the correction of carbohydrate metabolism and energetic state that were changed under type 2 diabetes. |
| first_indexed | 2024-12-22T04:25:53Z |
| format | Article |
| id | doaj.art-5f1d6893313142ceb8e1acaf34a166e3 |
| institution | Directory Open Access Journal |
| issn | 1996-4536 2311-0783 |
| language | English |
| last_indexed | 2024-12-22T04:25:53Z |
| publishDate | 2014-12-01 |
| publisher | Львівський національний університет імені Івана Франка |
| record_format | Article |
| series | Біологічні студії |
| spelling | doaj.art-5f1d6893313142ceb8e1acaf34a166e32022-12-21T18:39:10ZengЛьвівський національний університет імені Івана ФранкаБіологічні студії1996-45362311-07832014-12-0183-4415210.30970/sbi.0803.391Effect of combined nicotinamide, acetyl-L-carnitine and α-lipoic acid action on separate links of carbohydrate metabolism under experimental type 2 diabetesIu. T. Sergiichuk0T. M. Tykhonenko1M. M. Guzyk2L. V. Yanitska3T. M. Kuchmerovska4National Taras Shevchenko University, UkrainePalladin Institute of Biochemistry, NAS of UkrainePalladin Institute of Biochemistry, NAS of UkraineO.O. Bogomolets National Medical University, UkraineNational Taras Shevchenko University Palladin Institute of Biochemistry, NAS of UkraineThe effect of nicotinamide, acetyl-L-carnitine and α-lipoic acid on the separate links of carbohydrate metabolism in the brain, heart and liver of rats for type 2 diabetes it was investigated. Combined administration of nicotinamide, acetyl-L-carnitine and α-lipoic acid caused partial reduction of hyperglycemia in rats. By the action of investigated compounds activity of hexokinase and glucokinase, which were reduced under diabetes by 62 and 84 %, respectively, as compared to control was partially normalized. NAD contents in brain, heart and liver of diabetic rats were decreased by 46, 52 and 36 %, but were elevated by investigated compounds, especially in liver. It was found that ratio of free NAD/NADH and NADP/NADPH couples under diabetes were decreased in brain, liver and heart as compared to control. Redox-states in these tissues were significantly normalized by investigated compounds. Amino acid concentrations in blood serum of rats were altered and partially normalized by investigated compounds. Thus, combined effect of investigated compounds is more effective and can be used for the correction of carbohydrate metabolism and energetic state that were changed under type 2 diabetes.http://publications.lnu.edu.ua/journals/index.php/biology/article/view/195experimental type 2 diabetesnicotinamideacetyl-l-carnitineα-lipoic acidcarbohydrate metabolism |
| spellingShingle | Iu. T. Sergiichuk T. M. Tykhonenko M. M. Guzyk L. V. Yanitska T. M. Kuchmerovska Effect of combined nicotinamide, acetyl-L-carnitine and α-lipoic acid action on separate links of carbohydrate metabolism under experimental type 2 diabetes Біологічні студії experimental type 2 diabetes nicotinamide acetyl-l-carnitine α-lipoic acid carbohydrate metabolism |
| title | Effect of combined nicotinamide, acetyl-L-carnitine and α-lipoic acid action on separate links of carbohydrate metabolism under experimental type 2 diabetes |
| title_full | Effect of combined nicotinamide, acetyl-L-carnitine and α-lipoic acid action on separate links of carbohydrate metabolism under experimental type 2 diabetes |
| title_fullStr | Effect of combined nicotinamide, acetyl-L-carnitine and α-lipoic acid action on separate links of carbohydrate metabolism under experimental type 2 diabetes |
| title_full_unstemmed | Effect of combined nicotinamide, acetyl-L-carnitine and α-lipoic acid action on separate links of carbohydrate metabolism under experimental type 2 diabetes |
| title_short | Effect of combined nicotinamide, acetyl-L-carnitine and α-lipoic acid action on separate links of carbohydrate metabolism under experimental type 2 diabetes |
| title_sort | effect of combined nicotinamide acetyl l carnitine and α lipoic acid action on separate links of carbohydrate metabolism under experimental type 2 diabetes |
| topic | experimental type 2 diabetes nicotinamide acetyl-l-carnitine α-lipoic acid carbohydrate metabolism |
| url | http://publications.lnu.edu.ua/journals/index.php/biology/article/view/195 |
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