The Impact of Lens Epithelium-Derived Growth Factor p75 Dimerization on Its Tethering Function

The Impact of Lens Epithelium-Derived Growth Factor p75 Dimerization on Its Tethering Function

The transcriptional co-activator lens epithelium-derived growth factor/p75 (LEDGF/p75) plays an important role in the biology of the cell and in several human diseases, including MLL-rearranged acute leukemia, autoimmunity, and HIV-1 infection. In both health and disease, LEDGF/p75 functions as a ch...

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Bibliographic Details
Main Authors: Tine Brouns, Vanda Lux, Siska Van Belle, Frauke Christ, Václav Veverka, Zeger Debyser
Format: Article
Language:English
Published: MDPI AG 2024-01-01
Series:Cells
Subjects:
DNA-binding protein
protein–DNA interaction
protein–protein interaction
chromatin structure
protein dynamic
LEDGF/p75
Online Access:https://www.mdpi.com/2073-4409/13/3/227

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