Predicting Endothelium-Dependent Diastolic Function (FMD) and Its Correlation with the Degree of Coronary Artery Disease (CAD) and Plaque Vulnerability for Cardiovascular Events
Guangming Zhang,1 Jing Yang,1 Hanghang Xing,1 Hongning Yin,2 Guoqing Gu1 1Department of Cardiology, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, 050004, People’s Republic of China; 2Department of Heart ultrasound, The Second Hospital of Hebei Medical University, Shijiazhuang...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2024-03-01
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| Series: | International Journal of General Medicine |
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| Online Access: | https://www.dovepress.com/predicting-endothelium-dependent-diastolic-function-fmd-and-its-correl-peer-reviewed-fulltext-article-IJGM |
| _version_ | 1827309872320872448 |
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| author | Zhang G Yang J Xing H Yin H Gu G |
| author_facet | Zhang G Yang J Xing H Yin H Gu G |
| author_sort | Zhang G |
| collection | DOAJ |
| description | Guangming Zhang,1 Jing Yang,1 Hanghang Xing,1 Hongning Yin,2 Guoqing Gu1 1Department of Cardiology, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, 050004, People’s Republic of China; 2Department of Heart ultrasound, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, 050004, People’s Republic of ChinaCorrespondence: Guangming Zhang, Department of Cardiology, The Second Hospital of Hebei Medical University, 215, Heping West Road, Shijiazhuang, Hebei, 050004, People’s Republic of China, Tel +86 311-66002999, Email ZhangGuangming4@163.comObjective: This study aims to investigate the correlation between vascular endothelium-dependent diastolic function (FMD) and the degree of coronary artery disease (CAD), plaque vulnerability, and its predictive value for cardiovascular events.Methods: Initially, patients (n=100) who were admitted from January 2020 to January 2021 and intended to undergo percutaneous coronary intervention (PCI) were selected. Further, FMD in all patients was determined before the procedure and divided into a high-FMD group (≥ 4.2%) and a low-FMD group (< 4.2%). Further, the data of two groups, including general information, coronary artery lesions, and plaque fibrous cap, were compared. Finally, the relationship between FMD and the degree of coronary artery lesions and plaque vulnerability was analyzed.Results: No significant differences were observed concerning general information, number of coronary arteries-associated branches, lesion type, involvement of the left main stem (LM), the proportion of chronic occluded lesions (CTO), and lipid pool angle between the low-FMD group and the high-FMD group (P > 0.05). Nevertheless, the degree of stenosis of the lesions in the low-FMD group was significantly higher than in the high-FMD group (P < 0.05). In addition, the thickness of the fibrous cap was considerably lower than that in the high-FMD group (P < 0.05). Moreover, the incidence rate of TCFA was significantly higher than the high-FMD group (P < 0.05). The correlation analysis showed that FMD was significantly negatively correlated with the degree of coronary artery lesion stenosis and TCFA (P < 0.05) and positively correlated with the fibrous cap thickness (P < 0.05).Conclusion: Overall, a negative correlation between FMD and the degree of coronary stenosis, plaque vulnerability, and a high predictive value for post-PCI cardiovascular events suggested that FMD could be a critical diagnostic marker for CAD.Keywords: coronary heart disease, endothelium-dependent diastolic function, lesion extent, plaque vulnerability, predictive value |
| first_indexed | 2024-04-24T19:50:35Z |
| format | Article |
| id | doaj.art-5f216f5e390b4546bec3d46d66cd6804 |
| institution | Directory Open Access Journal |
| issn | 1178-7074 |
| language | English |
| last_indexed | 2024-04-24T19:50:35Z |
| publishDate | 2024-03-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | International Journal of General Medicine |
| spelling | doaj.art-5f216f5e390b4546bec3d46d66cd68042024-03-24T16:49:44ZengDove Medical PressInternational Journal of General Medicine1178-70742024-03-01Volume 171117112591469Predicting Endothelium-Dependent Diastolic Function (FMD) and Its Correlation with the Degree of Coronary Artery Disease (CAD) and Plaque Vulnerability for Cardiovascular EventsZhang GYang JXing HYin HGu GGuangming Zhang,1 Jing Yang,1 Hanghang Xing,1 Hongning Yin,2 Guoqing Gu1 1Department of Cardiology, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, 050004, People’s Republic of China; 2Department of Heart ultrasound, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, 050004, People’s Republic of ChinaCorrespondence: Guangming Zhang, Department of Cardiology, The Second Hospital of Hebei Medical University, 215, Heping West Road, Shijiazhuang, Hebei, 050004, People’s Republic of China, Tel +86 311-66002999, Email ZhangGuangming4@163.comObjective: This study aims to investigate the correlation between vascular endothelium-dependent diastolic function (FMD) and the degree of coronary artery disease (CAD), plaque vulnerability, and its predictive value for cardiovascular events.Methods: Initially, patients (n=100) who were admitted from January 2020 to January 2021 and intended to undergo percutaneous coronary intervention (PCI) were selected. Further, FMD in all patients was determined before the procedure and divided into a high-FMD group (≥ 4.2%) and a low-FMD group (< 4.2%). Further, the data of two groups, including general information, coronary artery lesions, and plaque fibrous cap, were compared. Finally, the relationship between FMD and the degree of coronary artery lesions and plaque vulnerability was analyzed.Results: No significant differences were observed concerning general information, number of coronary arteries-associated branches, lesion type, involvement of the left main stem (LM), the proportion of chronic occluded lesions (CTO), and lipid pool angle between the low-FMD group and the high-FMD group (P > 0.05). Nevertheless, the degree of stenosis of the lesions in the low-FMD group was significantly higher than in the high-FMD group (P < 0.05). In addition, the thickness of the fibrous cap was considerably lower than that in the high-FMD group (P < 0.05). Moreover, the incidence rate of TCFA was significantly higher than the high-FMD group (P < 0.05). The correlation analysis showed that FMD was significantly negatively correlated with the degree of coronary artery lesion stenosis and TCFA (P < 0.05) and positively correlated with the fibrous cap thickness (P < 0.05).Conclusion: Overall, a negative correlation between FMD and the degree of coronary stenosis, plaque vulnerability, and a high predictive value for post-PCI cardiovascular events suggested that FMD could be a critical diagnostic marker for CAD.Keywords: coronary heart disease, endothelium-dependent diastolic function, lesion extent, plaque vulnerability, predictive valuehttps://www.dovepress.com/predicting-endothelium-dependent-diastolic-function-fmd-and-its-correl-peer-reviewed-fulltext-article-IJGMcoronary heart diseaseendothelium-dependent diastolic functionlesion extentplaque vulnerabilitypredictive value |
| spellingShingle | Zhang G Yang J Xing H Yin H Gu G Predicting Endothelium-Dependent Diastolic Function (FMD) and Its Correlation with the Degree of Coronary Artery Disease (CAD) and Plaque Vulnerability for Cardiovascular Events International Journal of General Medicine coronary heart disease endothelium-dependent diastolic function lesion extent plaque vulnerability predictive value |
| title | Predicting Endothelium-Dependent Diastolic Function (FMD) and Its Correlation with the Degree of Coronary Artery Disease (CAD) and Plaque Vulnerability for Cardiovascular Events |
| title_full | Predicting Endothelium-Dependent Diastolic Function (FMD) and Its Correlation with the Degree of Coronary Artery Disease (CAD) and Plaque Vulnerability for Cardiovascular Events |
| title_fullStr | Predicting Endothelium-Dependent Diastolic Function (FMD) and Its Correlation with the Degree of Coronary Artery Disease (CAD) and Plaque Vulnerability for Cardiovascular Events |
| title_full_unstemmed | Predicting Endothelium-Dependent Diastolic Function (FMD) and Its Correlation with the Degree of Coronary Artery Disease (CAD) and Plaque Vulnerability for Cardiovascular Events |
| title_short | Predicting Endothelium-Dependent Diastolic Function (FMD) and Its Correlation with the Degree of Coronary Artery Disease (CAD) and Plaque Vulnerability for Cardiovascular Events |
| title_sort | predicting endothelium dependent diastolic function fmd and its correlation with the degree of coronary artery disease cad and plaque vulnerability for cardiovascular events |
| topic | coronary heart disease endothelium-dependent diastolic function lesion extent plaque vulnerability predictive value |
| url | https://www.dovepress.com/predicting-endothelium-dependent-diastolic-function-fmd-and-its-correl-peer-reviewed-fulltext-article-IJGM |
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