Acute and Cumulative Effects of Repeated Exposure to Chlorpyrifos on the Liver and Kidney Function among Egyptian Adolescents
Background: There is a paucity of research that tracks changes in liver and kidney function among pesticide applicators. The aim of the current study was to investigate the role of repeated seasonal exposure to the organophosphorus pesticide, chlorpyrifos, on serum measures of liver and kidney funct...
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| Format: | Article |
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MDPI AG
2021-06-01
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| Series: | Toxics |
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| Online Access: | https://www.mdpi.com/2305-6304/9/6/137 |
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| author | Ahmed A. Ismail Olfat Hendy Gaafar Abdel Rasoul James R. Olson Matthew R. Bonner Diane S. Rohlman |
| author_facet | Ahmed A. Ismail Olfat Hendy Gaafar Abdel Rasoul James R. Olson Matthew R. Bonner Diane S. Rohlman |
| author_sort | Ahmed A. Ismail |
| collection | DOAJ |
| description | Background: There is a paucity of research that tracks changes in liver and kidney function among pesticide applicators. The aim of the current study was to investigate the role of repeated seasonal exposure to the organophosphorus pesticide, chlorpyrifos, on serum measures of liver and kidney function. Methods: Pesticide exposure was assessed by measuring the urinary concentrations of 3,5,6-trichloro-2 pyridinol (TCPy), a specific biomarker for chlorpyrifos. Chlorpyrifos exposure and 8 serum markers of liver and kidney function were measured at 15 timepoints over 3 years prior to, during, and following the end of seasonal pesticide application among adolescent applicators and non-applicators from 4 field stations in Menoufia, Egypt. Results: Urinary TCPy levels showed increases during the application cycles and recovery at the end of each application season. Altered serum markers of liver and kidney function were associated with chlorpyrifos exposure, with some markers recovering 3 months after the end of exposure each year, while other measures demonstrated progressive increase up to 300% the baseline levels at the end of 3 years. Conclusion: The study demonstrated that frequent assessment of liver and kidney function is a sound practice to evaluate cellular injury following chronic repeated occupational and environmental exposure to chlorpyrifos. |
| first_indexed | 2024-03-10T10:31:12Z |
| format | Article |
| id | doaj.art-5f23af2cafa5418881902c35f2bee683 |
| institution | Directory Open Access Journal |
| issn | 2305-6304 |
| language | English |
| last_indexed | 2024-03-10T10:31:12Z |
| publishDate | 2021-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Toxics |
| spelling | doaj.art-5f23af2cafa5418881902c35f2bee6832023-11-21T23:39:16ZengMDPI AGToxics2305-63042021-06-019613710.3390/toxics9060137Acute and Cumulative Effects of Repeated Exposure to Chlorpyrifos on the Liver and Kidney Function among Egyptian AdolescentsAhmed A. Ismail0Olfat Hendy1Gaafar Abdel Rasoul2James R. Olson3Matthew R. Bonner4Diane S. Rohlman5Department of Occupational and Environmental Health, College of Public Health, University of Iowa, Iowa City, IA 52242, USADepartment of Clinical Pathology, National Liver Institute, Menoufia University, Shebin Elkom 32511, EgyptCommunity Medicine and Public Health Department, Faculty of Medicine, Menoufia University, Shebin Elkom 32511, EgyptDepartment of Epidemiology and Environmental Health, State University of New York, Buffalo, NY 14260, USADepartment of Epidemiology and Environmental Health, State University of New York, Buffalo, NY 14260, USADepartment of Occupational and Environmental Health, College of Public Health, University of Iowa, Iowa City, IA 52242, USABackground: There is a paucity of research that tracks changes in liver and kidney function among pesticide applicators. The aim of the current study was to investigate the role of repeated seasonal exposure to the organophosphorus pesticide, chlorpyrifos, on serum measures of liver and kidney function. Methods: Pesticide exposure was assessed by measuring the urinary concentrations of 3,5,6-trichloro-2 pyridinol (TCPy), a specific biomarker for chlorpyrifos. Chlorpyrifos exposure and 8 serum markers of liver and kidney function were measured at 15 timepoints over 3 years prior to, during, and following the end of seasonal pesticide application among adolescent applicators and non-applicators from 4 field stations in Menoufia, Egypt. Results: Urinary TCPy levels showed increases during the application cycles and recovery at the end of each application season. Altered serum markers of liver and kidney function were associated with chlorpyrifos exposure, with some markers recovering 3 months after the end of exposure each year, while other measures demonstrated progressive increase up to 300% the baseline levels at the end of 3 years. Conclusion: The study demonstrated that frequent assessment of liver and kidney function is a sound practice to evaluate cellular injury following chronic repeated occupational and environmental exposure to chlorpyrifos.https://www.mdpi.com/2305-6304/9/6/137adolescentsliver functionkidney functionorganophosphoruschlorpyrifoscholinesterase activity |
| spellingShingle | Ahmed A. Ismail Olfat Hendy Gaafar Abdel Rasoul James R. Olson Matthew R. Bonner Diane S. Rohlman Acute and Cumulative Effects of Repeated Exposure to Chlorpyrifos on the Liver and Kidney Function among Egyptian Adolescents Toxics adolescents liver function kidney function organophosphorus chlorpyrifos cholinesterase activity |
| title | Acute and Cumulative Effects of Repeated Exposure to Chlorpyrifos on the Liver and Kidney Function among Egyptian Adolescents |
| title_full | Acute and Cumulative Effects of Repeated Exposure to Chlorpyrifos on the Liver and Kidney Function among Egyptian Adolescents |
| title_fullStr | Acute and Cumulative Effects of Repeated Exposure to Chlorpyrifos on the Liver and Kidney Function among Egyptian Adolescents |
| title_full_unstemmed | Acute and Cumulative Effects of Repeated Exposure to Chlorpyrifos on the Liver and Kidney Function among Egyptian Adolescents |
| title_short | Acute and Cumulative Effects of Repeated Exposure to Chlorpyrifos on the Liver and Kidney Function among Egyptian Adolescents |
| title_sort | acute and cumulative effects of repeated exposure to chlorpyrifos on the liver and kidney function among egyptian adolescents |
| topic | adolescents liver function kidney function organophosphorus chlorpyrifos cholinesterase activity |
| url | https://www.mdpi.com/2305-6304/9/6/137 |
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