MDMA electrochemical determination in aqueous media containing illicit drugs and validation of a voltammetric methodology
MDMA is the abbreviation for 3,4-methylenedioxymethamphetamine, which is commonly found in “ecstasy” pills. The psychoactive and euphoric effects that MDMA causes make this substance an illicit drug that is constantly seized by police forces. We describe a low-cost and fast voltammetric methodology...
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| Format: | Article |
| Language: | English |
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Universidade Federal do Rio Grande do Sul
2020-07-01
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| Series: | Drug Analytical Research |
| Online Access: | https://seer.ufrgs.br/index.php/produto&producao/ojs/index.php/dar/article/view/101162 |
| _version_ | 1797311783832125440 |
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| author | Juliana Midori Toia Katayama Erica Naomi Oiye Maria Fernanda Muzetti Ribeiro Antônio José Ipólito José Fernando de Andrade Marcelo Firmino de Oliveira |
| author_facet | Juliana Midori Toia Katayama Erica Naomi Oiye Maria Fernanda Muzetti Ribeiro Antônio José Ipólito José Fernando de Andrade Marcelo Firmino de Oliveira |
| author_sort | Juliana Midori Toia Katayama |
| collection | DOAJ |
| description |
MDMA is the abbreviation for 3,4-methylenedioxymethamphetamine, which is commonly found in “ecstasy” pills. The psychoactive and euphoric effects that MDMA causes make this substance an illicit drug that is constantly seized by police forces. We describe a low-cost and fast voltammetric methodology that requires a carbon paste electrode (working electrode) in aqueous solution containing 0.1 mol L-1 LiClO4 as the supporting electrolyte. We conducted cyclic and square wave voltammetry and obtained limits of detection of 0.33 μg mL-1 and 0.36 μg mL-1, respectively, as others figures of merit for a complete validation. It includes the analysis main interfering substances, and results for seized samples were compared to those obtained by chromatography, which were close. An extended study of robustness were carried out by Youden’s test, that is inedited to electrochemical techniques when applied to forensic analysis. This test contributes to complete methodology validation and study of electrode cost and efficiency during electrochemical measurements involving a carbon paste electrode. In the end, this work presents a full validated methodology able to be applied in forensic laboratories.
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| first_indexed | 2024-03-08T02:04:48Z |
| format | Article |
| id | doaj.art-5f25d47c70474311b0f91f333c884903 |
| institution | Directory Open Access Journal |
| issn | 2527-2616 |
| language | English |
| last_indexed | 2024-03-08T02:04:48Z |
| publishDate | 2020-07-01 |
| publisher | Universidade Federal do Rio Grande do Sul |
| record_format | Article |
| series | Drug Analytical Research |
| spelling | doaj.art-5f25d47c70474311b0f91f333c8849032024-02-13T18:14:46ZengUniversidade Federal do Rio Grande do SulDrug Analytical Research2527-26162020-07-0141MDMA electrochemical determination in aqueous media containing illicit drugs and validation of a voltammetric methodologyJuliana Midori Toia Katayama0Erica Naomi Oiye1Maria Fernanda Muzetti Ribeiro2Antônio José Ipólito3José Fernando de Andrade4Marcelo Firmino de Oliveira5Universidade de São Paulo – USP – Faculdade de Filosofia Ciências e Letras de Ribeirão Preto – Departamento de Química – 14040-901 – Ribeirão Preto, São Paulo, BrazilUniversidade de São Paulo – USP – Faculdade de Filosofia Ciências e Letras de Ribeirão Preto – Departamento de Química – 14040-901 – Ribeirão Preto, São Paulo, BrazilUniversidade de São Paulo – USP – Faculdade de Filosofia Ciências e Letras de Ribeirão Preto – Departamento de Química – 14040-901 – Ribeirão Preto, São Paulo, BrazilSPTC – Núcleo de Perícias Criminalísticas de Ribeirão Preto – 14015-040 – Ribeirão Preto, São Paulo, BrazilUniversidade de São Paulo – USP – Faculdade de Filosofia Ciências e Letras de Ribeirão Preto – Departamento de Química – 14040-901 – Ribeirão Preto, São Paulo, BrazilUniversidade de São Paulo – USP – Faculdade de Filosofia Ciências e Letras de Ribeirão Preto – Departamento de Química – 14040-901 – Ribeirão Preto, São Paulo, Brazil MDMA is the abbreviation for 3,4-methylenedioxymethamphetamine, which is commonly found in “ecstasy” pills. The psychoactive and euphoric effects that MDMA causes make this substance an illicit drug that is constantly seized by police forces. We describe a low-cost and fast voltammetric methodology that requires a carbon paste electrode (working electrode) in aqueous solution containing 0.1 mol L-1 LiClO4 as the supporting electrolyte. We conducted cyclic and square wave voltammetry and obtained limits of detection of 0.33 μg mL-1 and 0.36 μg mL-1, respectively, as others figures of merit for a complete validation. It includes the analysis main interfering substances, and results for seized samples were compared to those obtained by chromatography, which were close. An extended study of robustness were carried out by Youden’s test, that is inedited to electrochemical techniques when applied to forensic analysis. This test contributes to complete methodology validation and study of electrode cost and efficiency during electrochemical measurements involving a carbon paste electrode. In the end, this work presents a full validated methodology able to be applied in forensic laboratories. https://seer.ufrgs.br/index.php/produto&producao/ojs/index.php/dar/article/view/101162 |
| spellingShingle | Juliana Midori Toia Katayama Erica Naomi Oiye Maria Fernanda Muzetti Ribeiro Antônio José Ipólito José Fernando de Andrade Marcelo Firmino de Oliveira MDMA electrochemical determination in aqueous media containing illicit drugs and validation of a voltammetric methodology Drug Analytical Research |
| title | MDMA electrochemical determination in aqueous media containing illicit drugs and validation of a voltammetric methodology |
| title_full | MDMA electrochemical determination in aqueous media containing illicit drugs and validation of a voltammetric methodology |
| title_fullStr | MDMA electrochemical determination in aqueous media containing illicit drugs and validation of a voltammetric methodology |
| title_full_unstemmed | MDMA electrochemical determination in aqueous media containing illicit drugs and validation of a voltammetric methodology |
| title_short | MDMA electrochemical determination in aqueous media containing illicit drugs and validation of a voltammetric methodology |
| title_sort | mdma electrochemical determination in aqueous media containing illicit drugs and validation of a voltammetric methodology |
| url | https://seer.ufrgs.br/index.php/produto&producao/ojs/index.php/dar/article/view/101162 |
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