Extracavitary Manifestation of Primary Effusion Lymphoma as a Right Atrial Mass
Primary effusion lymphoma (PEL) is a subset of large B cell lymphomas and has been mostly associated with human immunodeficiency virus infection. Rare cases have been reported in organ transplant recipients and chronic hepatitis C patients. It typically presents as an effusion in the pleural and per...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Karger Publishers
2013-02-01
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| Series: | Case Reports in Oncology |
| Subjects: | |
| Online Access: | http://www.karger.com/Article/FullText/346838 |
| _version_ | 1811294062995570688 |
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| author | Creticus P. Marak Ana M. Ponea Chang Shim Shagufta Shaheen Achuta K. Guddati |
| author_facet | Creticus P. Marak Ana M. Ponea Chang Shim Shagufta Shaheen Achuta K. Guddati |
| author_sort | Creticus P. Marak |
| collection | DOAJ |
| description | Primary effusion lymphoma (PEL) is a subset of large B cell lymphomas and has been mostly associated with human immunodeficiency virus infection. Rare cases have been reported in organ transplant recipients and chronic hepatitis C patients. It typically presents as an effusion in the pleural and pericardial spaces but rarely disseminates. However, involvement of the gastrointestinal tract, lymph nodes and bone marrow has been reported. Diagnosis is based on characteristic clinical, histopathological and immunohistochemical features. We present a case with a right atrial mass which tested positive for human herpes virus 8 (HHV-8), CD20, CD30 and lambda light chains and negative for CD138, kappa light chain, PAX5, Epstein-Barr virus, latent membrane protein 1, CD2, CD3, CD8 and CD56. Bilateral pleural effusions and pericardial effusions were noted which tested positive for HHV-8, CD30 and CD45. The patient responded well to the R-EPOCH regimen with complete resolution of the effusions and a significant decrease in the size of the right atrial mass. This case report illustrates the atypical manifestation of PEL as a right atrial mass. |
| first_indexed | 2024-04-13T05:12:03Z |
| format | Article |
| id | doaj.art-5f2a2302d5b144b892f3bb7ea764a892 |
| institution | Directory Open Access Journal |
| issn | 1662-6575 |
| language | English |
| last_indexed | 2024-04-13T05:12:03Z |
| publishDate | 2013-02-01 |
| publisher | Karger Publishers |
| record_format | Article |
| series | Case Reports in Oncology |
| spelling | doaj.art-5f2a2302d5b144b892f3bb7ea764a8922022-12-22T03:01:01ZengKarger PublishersCase Reports in Oncology1662-65752013-02-016111411810.1159/000346838346838Extracavitary Manifestation of Primary Effusion Lymphoma as a Right Atrial MassCreticus P. MarakAna M. PoneaChang ShimShagufta ShaheenAchuta K. GuddatiPrimary effusion lymphoma (PEL) is a subset of large B cell lymphomas and has been mostly associated with human immunodeficiency virus infection. Rare cases have been reported in organ transplant recipients and chronic hepatitis C patients. It typically presents as an effusion in the pleural and pericardial spaces but rarely disseminates. However, involvement of the gastrointestinal tract, lymph nodes and bone marrow has been reported. Diagnosis is based on characteristic clinical, histopathological and immunohistochemical features. We present a case with a right atrial mass which tested positive for human herpes virus 8 (HHV-8), CD20, CD30 and lambda light chains and negative for CD138, kappa light chain, PAX5, Epstein-Barr virus, latent membrane protein 1, CD2, CD3, CD8 and CD56. Bilateral pleural effusions and pericardial effusions were noted which tested positive for HHV-8, CD30 and CD45. The patient responded well to the R-EPOCH regimen with complete resolution of the effusions and a significant decrease in the size of the right atrial mass. This case report illustrates the atypical manifestation of PEL as a right atrial mass.http://www.karger.com/Article/FullText/346838Primary effusion lymphomaRight atrial massR-EPOCHHuman herpes virus 8 |
| spellingShingle | Creticus P. Marak Ana M. Ponea Chang Shim Shagufta Shaheen Achuta K. Guddati Extracavitary Manifestation of Primary Effusion Lymphoma as a Right Atrial Mass Case Reports in Oncology Primary effusion lymphoma Right atrial mass R-EPOCH Human herpes virus 8 |
| title | Extracavitary Manifestation of Primary Effusion Lymphoma as a Right Atrial Mass |
| title_full | Extracavitary Manifestation of Primary Effusion Lymphoma as a Right Atrial Mass |
| title_fullStr | Extracavitary Manifestation of Primary Effusion Lymphoma as a Right Atrial Mass |
| title_full_unstemmed | Extracavitary Manifestation of Primary Effusion Lymphoma as a Right Atrial Mass |
| title_short | Extracavitary Manifestation of Primary Effusion Lymphoma as a Right Atrial Mass |
| title_sort | extracavitary manifestation of primary effusion lymphoma as a right atrial mass |
| topic | Primary effusion lymphoma Right atrial mass R-EPOCH Human herpes virus 8 |
| url | http://www.karger.com/Article/FullText/346838 |
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