Small molecules block the interaction between porcine reproductive and respiratory syndrome virus and CD163 receptor and the infection of pig cells

Small molecules block the interaction between porcine reproductive and respiratory syndrome virus and CD163 receptor and the infection of pig cells

Abstract Background Porcine reproductive and respiratory syndrome (PRRS) is one of the most economically devastating diseases affecting the pork industry globally. PRRS is caused by PRRS virus (PRRSV). Currently there are no effective treatments against this swine disease. Methods Through artificial...

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Bibliographic Details
Main Authors: Chang Huang, Denzil Bernard, Jiaqi Zhu, Radha Charan Dash, Alexander Chu, Alec Knupp, Anna Hakey, M. Kyle Hadden, Antonio Garmendia, Young Tang
Format: Article
Language:English
Published: BMC 2020-07-01
Series:Virology Journal
Subjects:
Porcine reproductive and respiratory syndrome (PRRS)
PRRS viruses (PRRSV)
CD163
Protein-protein interaction (PPI)
Scavenger receptor cysteine-rich domain 5 (SRCR5)
Bimolecular fluorescence complementation (BiFC)
Online Access:http://link.springer.com/article/10.1186/s12985-020-01361-7

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